Patents by Inventor Enrique Alvarez

Enrique Alvarez has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • APPARATUSES AND METHODS FOR GENERATING PSEUDO-RANDOM NUMBER
    Publication number: 20250147730
    Abstract: Aspects of the present disclosure include a multiplexer having a plurality of input terminals each configured to receive a corresponding input value of a plurality of input values, an output terminal configured to output an output value of a white pseudo-random sequence and provide a delayed output value into a feedback loop, a feedback input terminal configured to receive a feedback value via the feedback loop, wherein the feedback value is the product of the delayed output value and a first value of a first pseudo-random sequence, and a select terminal configured to receive a second value of a second pseudo-random sequence and select, based on the second value, one of a combination of the plurality of input terminals and the feedback input terminal.
    Type: Application
    Filed: November 7, 2023
    Publication date: May 8, 2025
    Inventors: Enrique ALVAREZ FONTECILLA, Paul S. WILKINS
  • DIAGNOSING MULTIPLE SCLEROSIS (MS)
    Publication number: 20250012795
    Abstract: Compositions and methods for diagnosing and treating multiple sclerosis (MS) and other health conditions involve collecting serum samples from a subject and exposing the serum samples to a protein capture composition, collecting the unbound eluent or flow-through, and measuring the levels of at least one immunoglobulin therein. Methods for differentiating between different types of MS also involve exposing serum samples to a protein capture composition and detecting immunoglobulin levels in the flow-through. Based on the detected immunoglobulin levels, an MS subtype is diagnosed in a subject and a treatment regimen can be adjusted or ceased according to the diagnosis.
    Type: Application
    Filed: September 29, 2022
    Publication date: January 9, 2025
    Inventors: Xiaoli Yu, Michael Graner, Wenbo Zhou, Timothy Vollmer, Enrique Alvarez
  • APPARATUSES AND METHODS FOR EFFICIENT SHUFFLING IN A DIGITAL TO ANALOG CONVERTER
    Publication number: 20240259028
    Abstract: Aspects of the present disclosure include receiving a digital input signal having an identified value, determining a number of a plurality of converters, determining, based on the identified value and the number, a minimum number of one or more minimum output configurations, parsing the digital input into a plurality of individual bits, and transmitting the plurality of individual bits to the plurality of converters based on an output configuration of the one or more minimum output configurations.
    Type: Application
    Filed: January 27, 2023
    Publication date: August 1, 2024
    Inventors: Enrique ALVAREZ FONTECILLA, Paul WILKINS
  • DIRECTED CONJUGATION TECHNOLOGIES
    Publication number: 20230128688
    Abstract: Among other things, the present disclosure provides technologies for site-directed conjugation of various moieties of interest to target agents. In some embodiments, the present disclosure utilizes target binding moieties to provide high conjugation efficiency and selectivity. In some embodiments, provided technologies are useful for preparing antibody conjugates.
    Type: Application
    Filed: November 18, 2020
    Publication date: April 27, 2023
    Inventors: Luca RASTELLI, David Adam SPIEGEL, Matthew Ernest WELSCH, Tetyana BERBASOVA, Michael C. CUKAN, Lawrence Gerald IBEN, Ada Margaret VAILL, Anna BUNIN, Christian Marcel VIDAL, Enrique ALVAREZ
  • Frequency to digital converter, asynchronous phase sampler and digitally controlled oscillator methods
    Patent number: 11437980
    Abstract: A ?? frequency to digital converter includes digital feedback to an accumulator in a ring phase calculator that provides the converter output, which reduces implantation complexity. Digital gain correction is applicable to dual mode ring oscillator converters and charge pump converters, provides compensation for forward path gain error and eliminates the need to include analog gain correction in feedback. Asynchronous sampling includes correction logic to compensate for arbitrary initial conditions. A digitally-controlled oscillator (DCO) control technique causes the DCO frequency to increase or decrease by changing the state of one its frequency control elements at a time.
    Type: Grant
    Filed: December 2, 2020
    Date of Patent: September 6, 2022
    Assignee: The Regents of the University of California
    Inventors: Ian Galton, Enrique Alvarez-Fontecilla, Amr Eissa
  • FREQUENCY TO DIGITAL CONVERTER, ASYNCHRONOUS PHASE SAMPLER AND DIGITALLY CONTROLLED OSCILLATOR METHODS
    Publication number: 20210175878
    Abstract: A ?? frequency to digital converter includes digital feedback to an accumulator in a ring phase calculator that provides the converter output, which reduces implantation complexity. Digital gain correction is applicable to dual mode ring oscillator converters and charge pump converters, provides compensation for forward path gain error and eliminates the need to include analog gain correction in feedback. Asynchronous sampling includes correction logic to compensate for arbitrary initial conditions. A digitally-controlled oscillator (DCO) control technique causes the DCO frequency to increase or decrease by changing the state of one its frequency control elements at a time.
    Type: Application
    Filed: December 2, 2020
    Publication date: June 10, 2021
    Inventors: Ian Galton, Enrique Alvarez-Fontecilla, Amr Eissa
  • Multi-rate DEM with mismatch noise cancellation for digitally-controlled oscillators
    Patent number: 10735005
    Abstract: A digital fractional-N phase locked loop (PLL) with multi-rate dynamic element matching (DEM) and an adaptive mismatch-noise cancellation (MNC) is provided. The PLL includes a phase error to digital converter and a digital loop filter to suppress quantization noise of the phase error to digital converter and drive a digitally controlled oscillator. A digitally controlled oscillator (DCO) with a multi-rate DEM encoder includes an integer bank of frequency control elements (FCE) and a fractional bank of frequency control elements. Adaptive mismatch-noise cancellation logic operates to cancel DCO phase error arising from frequency control element (FCE) static and dynamic mismatch error by estimating ideal MNC coefficient values during PLL normal operation, estimating MNC coefficient errors at each sample time, and updating the MNC coefficient values to approach zero (FCE) static and dynamic mismatch error.
    Type: Grant
    Filed: August 21, 2019
    Date of Patent: August 4, 2020
    Assignee: The Regents of the University of California
    Inventors: Ian Galton, Enrique Alvarez-Fontecilla
  • MULTI-RATE DEM WITH MISMATCH NOISE CANCELLATION FOR DIGITALLY-CONTROLLED OSCILLATORS
    Publication number: 20200067514
    Abstract: A digital fractional-N phase locked loop (PLL) with multi-rate dynamic element matching (DEM) and an adaptive mismatch-noise cancellation (MNC) is provided. The PLL includes a phase error to digital converter and a digital loop filter to suppress quantization noise of the phase error to digital converter and drive a digitally controlled oscillator. A digitally controlled oscillator (DCO) with a multi-rate DEM encoder includes an integer bank of frequency control elements (FCE) and a fractional bank of frequency control elements. Adaptive mismatch-noise cancellation logic operates to cancel DCO phase error arising from frequency control element (FCE) static and dynamic mismatch error by estimating ideal MNC coefficient values during PLL normal operation, estimating MNC coefficient errors at each sample time, and updating the MNC coefficient values to approach zero (FCE) static and dynamic mismatch error.
    Type: Application
    Filed: August 21, 2019
    Publication date: February 27, 2020
    Inventors: Ian Galton, Enrique Alvarez-Fontecilla
  • COCKTAIL MIX TECHNOLOGY
    Publication number: 20170327777
    Abstract: The invention provides a cocktail mix composition that includes: (a) one or more fruits, herbs, spices, and/or vegetables, and (b) pectin. The cocktail mix composition has a viscosity of less than 250 centistokes.
    Type: Application
    Filed: May 10, 2017
    Publication date: November 16, 2017
    Inventor: Jorge Enrique Alvarez
  • Internet vehicle data logger framework that provide data controller by the user in standardized human understandable format via web services
    Patent number: 8930502
    Abstract: Software applications that retrieve, log, and communicate vehicle-related data are implemented within a system that includes a plurality of vehicles, a worldwide network, at least one web server, at least one database server, and a plurality of internet-enabled back-end devices. Each vehicle has at least one internet-enabled front-end device, which is communicably coupled to the vehicle's computer system access device. The internet-enabled front-end device of each vehicle retrieves the vehicle-related data through a software application, which is also used to send the vehicle-related data to the web server. The web server collects data from each vehicle and properly organizes and stores the data on the database server. The web server and the database service implements a system software to manage and process the data from each vehicle. Once the system software processes the data, the internet-enabled back-end devices can access the data through external applications or information systems.
    Type: Grant
    Filed: December 7, 2012
    Date of Patent: January 6, 2015
    Inventor: Cesar Enrique Alvarez Rodriguez
  • INTERNET VEHICLE DATA LOGGER FRAMEWORK THAT PROVIDE DATA CONTROLLED BY THE USER IN STANDARDIZED HUMAN UNDERSTANDABLE FORMAT VIA WEB SERVICES
    Publication number: 20130151671
    Abstract: Software applications that retrieve, log, and communicate vehicle-related data are implemented within a system that includes a plurality of vehicles, a worldwide network, at least one web server, at least one database server, and a plurality of internet-enabled back-end devices. Each vehicle has at least one internet-enabled front-end device, which is communicably coupled to the vehicle's computer system access device. The internet-enabled front-end device of each vehicle retrieves the vehicle-related data through a software application, which is also used to send the vehicle-related data to the web server. The web server collects data from each vehicle and properly organizes and stores the data on the database server. The web server and the database service implements a system software to manage and process the data from each vehicle. Once the system software processes the data, the internet-enabled back-end devices can access the data through external applications or information systems.
    Type: Application
    Filed: December 7, 2012
    Publication date: June 13, 2013
    Inventor: Cesar Enrique Alvarez Rodriguez
  • Anchor system for use in an aquatic environment
    Publication number: 20060287166
    Abstract: An anchorage system for use in an aquatic environment, which has a stationary base, a cylinder, and a piston useful for practicing stationary swimming and/or rehabilitation.
    Type: Application
    Filed: June 16, 2006
    Publication date: December 21, 2006
    Inventor: Enrique Alvarez
  • Therapeutic polypeptides, nucleic acids encoding same, and methods of use
    Publication number: 20060003323
    Abstract: Disclosed herein are nucleic acid sequences that encode novel polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies that immunospecifically bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the novel polypeptide, polynucleotide, or antibody specific to the polypeptide. Vectors, host cells, antibodies and recombinant methods for producing the polypeptides and polynucleotides, as well as methods for using same are also included. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.
    Type: Application
    Filed: June 3, 2003
    Publication date: January 5, 2006
    Inventors: John Alsobrook, Enrique Alvarez, David Anderson, Ferenc Boldog, Stacie Casman, Elina Catterton, Andrei Chapoval, Julie Crabtree-Bokor, Shlomit Edinger, Karen Ellerman, Seth Ettenberg, Esha Gangolli, Valerie Gerlach, Linda Gorman, Erik Gunther, Xiaojia (Sasha) Guo, Vladimir Gusev, John Herrmann, Weizhen Ji, Ramesh Kekuda, Li Li, Xiaohong Liu, John MacDougall, Timothy Machlachlan, Uriel Malyankar, Amanda Mezick, Isabelle Millet, Vishnu Mishra, Muralidhara Padigaru, Meera Patturajan, Carol Pena, John Peyman, Debasish Raha, Luca Rastelli, Daniel Rieger, Mark Rothenberg, Paul Sciore, Suresh Shenoy, Richard Shimkets, Glennda Smithson, Kimberly Spytek, David Stone, Corine Vernet, Edward Voss, Mei Zhong, Hiahong Zhong
  • Methods of preventing and treating alimentary mucositis
    Publication number: 20050256042
    Abstract: The present invention relates to compositions and methods for preventing and treating alimentary mucositis. More particularly, the present invention provides methods for preventing and/or treating alimetary mucositis by using compositions comprising FGF-20, a fragment, a derivative, a variant, a homolog, or an analog thereof.
    Type: Application
    Filed: November 3, 2004
    Publication date: November 17, 2005
    Inventors: Michael Jeffers, Zachary Yim, Pascal Valax, Pradyumna Namdev, Rajeev Chillakuru, William LaRochelle, Henri Lichenstein, Enrique Alvarez, William Hahne
  • Prophylactic and therapeutic uses of FGF-20 in radiation protection
    Publication number: 20050215473
    Abstract: The present invention relates to methods of stimulating stem cell proliferation and engraftment, and methods of preventing and/or treating disorders associated with radiation exposure, chemotherapy, exposed to chemical/biological warfare agents, and/or any other insults affecting rapidly proliferating tissues in a body, or one or more symptoms thereof. In particular, the present invention provides methods of stimulating stem cell proliferation and/or engraftment and methods of preventing and/or treating disorders associated with one or more insults affecting rapidly proliferating tissues in a body (e.g., radiation exposure, chemical and/or biological insults) or one or more symptoms thereof by administering to a subject a composition comprising a Fibroblast Growth Factor-20 (FGF-20) protein, or its fragments, derivatives, variants, homologs, analogs, or a combination thereof.
    Type: Application
    Filed: November 3, 2004
    Publication date: September 29, 2005
    Inventors: Enrique Alvarez, Timothy MacLachlan, Bisni Narayanan, William Hahne
  • Methods of preventing and treating inflammatory bowel disease
    Publication number: 20050164929
    Abstract: The present invention relates to compositions and methods for preventing and treating an inflammatory disorder of a mucosa, including but is not limited to, inflammatory bowel disease and irritable bowel syndrome. More particularly, the present invention relates to compositions comprising FGF-20, a fragment, a derivative, a variant, a homolog, or an analog thereof, and their uses in preventing and treating an inflammatory disorder of a mucosa, such as inflammatory bowel disease or irritable bowel syndrome.
    Type: Application
    Filed: November 3, 2004
    Publication date: July 28, 2005
    Applicant: LUPINE LOGIC, INC.
    Inventors: Enrique Alvarez, Jeffrey Peterson, William LaRochelle, Henri Lichenstein, Michael Jeffers
  • Therapeutic polypeptides, nucleic acids encoding same, and methods of use
    Publication number: 20040259774
    Abstract: Disclosed herein are nucleic acid sequences that encode novel polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies that immunospecifically bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the novel polypeptide, polynucleotide, or antibody specific to the polypeptide. Vectors, host cells, antibodies and recombinant methods for producing the polypeptides and polynucleotides, as well as methods for using same are also included. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.
    Type: Application
    Filed: February 3, 2003
    Publication date: December 23, 2004
    Inventors: Enrique Alvarez, Shlomit R. Edinger, Esha A. Gangolli, Valerie Gerlach, Linda Gorman, Xiaojia (Sasha) Guo, Weizhen Ji, Ramesh Kekuda, Li Li, Charles E. Miller, Muralidhara Padigaru, Meera Patturajan, Luca Rastelli, Daniel K. Rieger, Suresh G. Shenoy, Richard A. Shimkets, Kimberly A. Spytek, Mei Zhong
  • Compositions and methods of use for a fibroblast growth factor
    Publication number: 20040214759
    Abstract: In methods of using a fibroblast growth factor, such as for treating, preventing or delaying a proliferation-associated disorder, steps are provided to administer to a subject a therapeutically effective amount of a particular fibroblast growth factor polypeptide, or variant or fragment thereof.
    Type: Application
    Filed: May 9, 2003
    Publication date: October 28, 2004
    Inventors: John P. Alsobrook, Enrique Alvarez, David W. Anderson, Joel S. Bader, Ferenc L. Boldog, Catherine E. Burgess, Rajeev A. Chillakuru, Lisa Deegler, Shlomit R. Edinger, Elma R. Fernandes, Linda Gorman, William M. Grosse, John L. Herrmann, Michael E. Jeffers, William J. LaRochelle, Denise M. Lepley, Henri S. Lichenstein, Kumar Namdev, Muralidhara Padigaru, Carol E. A. Pena, Sudhirdas K. Prayaga, Daniel K. Rieger, Richard A. Shimkets, Pascal Valax, Meijia Yang, Zachary Yim, Mei Zhong
  • Therapeutic polypeptides, nucleic acids encoding same, and methods of use
    Publication number: 20040067505
    Abstract: The present invention provides novel isolated polynucleotides and small molecule target polypeptides encoded by the polynucleotides. Antibodies that immunospecifically bind to a novel small molecule target polypeptide or any derivative, variant, mutant or fragment of that polypeptide, polynucleotide or antibody are disclosed, as are methods in which the small molecule target polypeptide, polynucleotide and antibody are utilized in the detection and treatment of a broad range of pathological states. More specifically, the present invention discloses methods of using recombinantly expressed and/or endogenously expressed proteins in various screening procedures for the purpose of identifying therapeutic antibodies and therapeutic small molecules associated with diseases. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.
    Type: Application
    Filed: May 1, 2003
    Publication date: April 8, 2004
    Inventors: Enrique Alvarez, David Anderson, Ferenc Boldog, Elina Catterton, Shlomit R. Edinger, Elma Fernandes, Valerie Gerlach, Linda Gorman, William Grosse, Xiaojia (Sasha) Guo, Weizhen Ji, Ramesh Kekuda, Li Li, John R. MacDougall, Muralidhara Padigaru, Meera Patturajan, Jeffery D. Peterson, Luca Rastelli, Richard Shimkets, Kimberly Spytek, David J. Stone, Corine A.M. Vernet, Edward Voss, Mei Zhong
  • Therapeutic polypeptides, nucleic acids encoding same, and methods of use
    Publication number: 20040067882
    Abstract: Disclosed herein are nucleic acid sequences that encode novel polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies that immunospecifically bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the novel polypeptide, polynucleotide, or antibody specific to the polypeptide. Vectors, host cells, antibodies and recombinant methods for producing the polypeptides and polynucleotides, as well as methods for using same are also included. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.
    Type: Application
    Filed: November 5, 2002
    Publication date: April 8, 2004
    Inventors: John P. Alsobrook, Enrique Alvarez, David W. Anderson, Melanie Baron, Ferenc L. Boldog, Catherine E. Burgess, Stacie J. Casman, Andrei Chapoval, Mohanraj Dhanabal, Shlomit R. Edinger, Andrew Eisen, Karen Ellerman, Seth Ettenberg, Esha A. Gangolli, Valerie Gerlach, Linda Gorman, William M. Grosse, Xiaojia (Sasha) Guo, Craig Hackett, Weizhen Ji, Ramesh Kekuda, Nikolai V. Khramtsov, Denise M. Lepley, Li Li, John R. MacDougall, Uriel M. Malyankar, Ann Mazur, Kelly McQueeney, Peter S. Mezes, Charles E. Miller, Isabelle Millet, Vishnu Mishra, Muralidhara Padigaru, Meera Patturajan, Carol E. A. Pena, John A. Peyman, Luca Rastelli, Daniel K. Rieger, Mark E. Rothenberg, Suresh G. Shenoy, Richard A. Shimkets, Glennda Smithson, Steven K. Spaderna, Gary Starling, Kimberly A. Spytek, David J. Stone, Velizar T. Tchernev, Nancy Twomlow, Corine A.M. Vernet, Bryan D. Zerhusen, Edward Z. Voss, Mei Zhong