Patents by Inventor Enrique C. Leira

Enrique C. Leira has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Replication or mitigation of low frequency vibration and other physical factors to enhance the effect of thrombolysis on patients with ischemic stroke
    Patent number: 12036384
    Abstract: The disclosed apparatus, systems and methods relate to devices, systems and methods for improving thrombolysis via synergetic application of thrombolytics with physical factors, such as in acute ischemic stroke patients. Vibration in the low (0.5-120 Hz) frequency range is synergistic with tissue plasminogen activators (rtPA), significantly improving the effectiveness of thrombolysis without impairing blood brain barrier permeability. Administration of low frequency vibration combined with rtPA improve acute ischemic stroke outcomes.
    Type: Grant
    Filed: February 5, 2020
    Date of Patent: July 16, 2024
    Assignee: University of lowa Research Foundation
    Inventors: Enrique C. Leira, Thomas Schnell, Salam F. Rahmatalla, Andrew A. Pieper, Anil Chauhan
  • THE REPLICATION OR MITIGATION OF LOW FREQUENCY VIBRATION AND OTHER PHYSICAL FACTORS TO ENHANCE THE EFFECT OF THROMBOLYSIS ON PATIENTS WITH ISCHEMIC STROKE
    Publication number: 20200316289
    Abstract: The disclosed apparatus, systems and methods relate to devices, systems and methods for improving thrombolysis via synergetic application of thrombolytics with physical factors, such as in acute ischemic stroke patients. Vibration in the low (0.5-120 Hz) frequency range is synergistic with tissue plasminogen activators (rtPA), significantly improving the effectiveness of thrombolysis without impairing blood brain barrier permeability. Administration of low frequency vibration combined with rtPA improve acute ischemic stroke outcomes.
    Type: Application
    Filed: February 5, 2020
    Publication date: October 8, 2020
    Inventors: Enrique C. Leira, Thomas Schnell, Salam F. Rahmatalla, Andrew A. Pieper, Anil Chauhan