Abstract: A postal and package receptacle includes a main body that has an open top and a lid over the top that is movable between an open position and a closed position. The lid is moved from the open to the closed position upon receiving an open command via a wireless communication, whereupon a package can be placed in the interior of the main body. After a package is placed in the interior of the main body, the lid can be closed. A drone can be programmed to deliver a package to the postal and package receptacle and upon arriving at the location of the postal and package receptacle, the drone can communicate with the postal and package receptacle to issue the open and close commands, accordingly.

Abstract: A postal and package receptacle includes a main body that has an open top and a lid over the top that is movable between an open position and a closed position. The lid is moved from the open to the closed position upon receiving an open command via a wireless communication, whereupon a package can be placed in the interior of the main body. After a package is placed in the interior of the main body, the lid can be closed. A drone can be programmed to deliver a package to the postal and package receptacle and upon arriving at the location of the postal and package receptacle, the drone can communicate with the postal and package receptacle to issue the open and close commands, accordingly.

Abstract: Disclosed are compounds of formula: that inhibiting GPBP activity, making them useful as therapeutics in antibody-mediated disorders, drug-resistant cancer, inflammation, protein misfolding and ER stress-mediated disorders, and aberrant apoptosis.

Abstract: Disclosed are compounds of formula: that inhibiting GPBP activity, making them useful as therapeutics in antibody-mediated disorders, drug-resistant cancer, inflammation, protein misfolding and ER stress-mediated disorders, and aberrant apoptosis.

Abstract: A touch-sensitive rotary control device with an illumination function includes a rotary encoder having a conductive outer casing and a rotatable shaft extending from it, the shaft operating as a light guide for a light source located in the rotary encoder, a conductive sleeve mechanically coupled to and surrounding the side of shaft, and electrically coupled to the conductive outer casing of the rotary encoder, so that touch-sensitivity is provided and light is allowed to exit the shaft and such that the device can be provided as a kit of parts or form part of a mixing console.

Abstract: Disclosed are compounds of formula: that inhibiting GPBP activity, making them useful as therapeutics in antibody-mediated disorders, drug-resistant cancer, inflammation, protein misfolding and ER stress-mediated disorders, and aberrant apoptosis.

Abstract: Disclosed are compounds of formula: that inhibiting GPBP activity, making them useful as therapeutics in antibody-mediated disorders, drug-resistant cancer, inflammation, protein misfolding and ER stress-mediated disorders, and aberrant apoptosis.

Abstract: Disclosed is a method of reviewing a set of rules used for automated monitoring of a technical system for the presence of a problem. The method includes the steps of: selecting a problem in view of which the set of rules is to be reviewed; translating the rules to be reviewed to a knowledge base of formal logical statements; translating the problem to a formal logical problem statement; applying a computer algorithm for checking whether the knowledge base of logical statements together with the logical problem statement is satisfiable; labeling the problems as not being present if the knowledge base of logical statements together with the logical problem statement is satisfiable.

Abstract: A touch-sensitive rotary control device with an illumination function includes a rotary encoder having a conductive outer casing and a rotatable shaft extending from it, the shaft operating as a light guide for a light source located in the rotary encoder, a conductive sleeve mechanically coupled to and surrounding the side of shaft, and electrically coupled to the conductive outer casing of the rotary encoder, so that touch-sensitivity is provided and light is allowed to exit the shaft and such that the device can be provided as a kit of parts or form part of a mixing console.

Abstract: Derivatives of 2,5-piperazinedione of formula (I) are apoptotic peptidase activating factor 1 (Apaf-1) inhibitors, therefore they are useful as active pharmaceutical ingredients for the prophylaxis and/or treatment of a pathological and/or physiological condition associated with an increase of apoptosis.

Abstract: Disclosed are compounds of formula: that inhibiting GPBP activity, making them useful as therapeutics in antibody-mediated disorders, drug-resistant cancer, inflammation, protein misfolding and ER stress-mediated disorders, and aberrant apoptosis.

Abstract: Disclosed are compounds of formula: that inhibiting GPBP activity, making them useful as therapeutics in antibody-mediated disorders, drug-resistant cancer, inflammation, protein misfolding and ER stress-mediated disorders, and aberrant apoptosis.

Abstract: Compounds to be used in the treatment of diseases based on the expression of toxic transcripts. The present invention relates to peptide molecules, specifically hexapeptides, designed for the prevention and/or treatment of diseases the etiology whereof is based on the presence of toxic transcripts that comprise CUG, CCUG, CGG, CAG and AAG repeats, preferably: DM1 SCA8, DM2, FXTAS, HD and FA.

Abstract: Derivatives of 2,5-piperazinedione of formula (I) are apoptotic peptidase activating factor 1 (Apaf-1) inhibitors, therefore they are useful as active pharmaceutical ingredients for the prophylaxis and/or treatment of a pathological and/or physiological condition associated with an increase of apoptosis.

Abstract: The invention relates to non-proteolysable oligopeptides that inhibit glycoprotein 41 of the AIDS virus. More specifically, the invention relates to the identification of oligopeptides, particularly hexapeptides, (D), (L) or mixed, preferably D-hexapeptides, which inhibit the binding of a retrovirus to a target cell, thereby providing novel therapies against infection from the human immunodeficiency virus (HIV). The invention also relates to the use of said D-hexapeptides in the form of single components or complex mixtures as prophylactic or therapeutic agents for retroviral infections, especially human immunodeficiency virus type 1 (HIV-1).

Abstract: Disclosed are compounds of formula: that inhibiting GPBP activity, making them useful as therapeutics in antibody-mediated disorders, drug-resistant cancer, inflammation, protein misfolding and ER stress-mediated disorders, and aberrant apoptosis.

Abstract: The invention relates to non-proteolysable oligopeptides that inhibit glycoprotein 41 of the AIDS virus. More specifically, the invention relates to the identification of oligopeptides, particularly hexapeptides, (D), (L) or mixed, preferably D-hexapeptides, which inhibit the binding of a retrovirus to a target cell, thereby providing novel therapies against infection from the human immunodeficiency virus (HIV). The invention also relates to the use of said D-hexapeptides in the form of single components or complex mixtures as prophylactic or therapeutic agents for retroviral infections, especially human immunodeficiency virus type 1 (HIV-1).

Abstract: A device for the actuation of vehicle brakes has a pull element which can be brought into a lockable braking position in order to pull at least a part of a vehicle brake, the pull element being capable of being tensioned by a tension element in this braking position, and which can be brought into a released position, in which the pull element is relaxed to an extent such that the at least a part of the vehicle brake is released, the device being provided with a retensioning device which, in the released position, automatically retensions the pull element.

Abstract: The present invention relates to compounds of formula (I) as well as to drug conjugates based on compounds of formula (I) acting as apoptosis inhibitors, as well as to processes for their preparation, to pharmaceutical compositions containing them and their use in medicine.

Abstract: An apparatus includes a base that has a thermo-resistive top surface and oppositely seated edges that have apertures formed therein. A top casing has an inner perimeter aligned above the base and maintains a fixed elevated spatial relationship therewith. The top casing has holes formed along an outer perimeter thereof, and is formed from non-conductive and transparent material. Elongated pegs have bores formed therethrough and have opposed ends coupled to a top casing bottom surface and a base top surface. The axial bores are aligned with the apertures and the holes for receiving fasteners therethrough. The portable computer is nested on the base and interfitted between the inner perimeter of the top casing such that the portable computer is advantageously restricted from moving. The portable computer is spaced from the user's genitalia such that heat generated from the portable computer is dissipated away from the user's genitalia.