Abstract: A disposable highly-protective oral-nasal mask comprises a fixing part. A notch is formed in the portion, corresponding to an oral cavity, of the fixing part. An oral cavity coverage part is arranged at the notch, corresponding to the oral cavity, of the fixing part, and is detachably connected to the fixing part. A first fold part with upward external folds is further arranged on the oral cavity coverage part. A second fold part with downward external folds is arranged on a nasal cavity coverage part. Two easily deformed components are located in accommodating cavities which are formed in the fixing part in one-to-one correspondence with the easily deformed components. Both accommodating cavities are arranged in the length direction of the fixing part. One accommodating cavity is located between the oral cavity coverage part and the nasal cavity coverage part, and the other accommodating cavity is located above the nasal cavity coverage part.