Patents by Inventor Enwu Liu
Enwu Liu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 12018265Abstract: The gene encoding N-methylputrescine oxidase (MPO) and constructs comprising such DNA are provided, including methods of regulating MPO expression independently or with other alkaloid biosynthesis genes to modulate alkaloid production in plants and host cells. MPO genes or fragments thereof are useful for reducing pyrrolidine or tropane alkaloid production in plants, for increasing pyrrolidine or tropane alkaloid production in plants, and for producing an MPO enzyme in host cells.Type: GrantFiled: June 22, 2022Date of Patent: June 25, 2024Assignee: 22nd Century Limited, LLCInventors: Jonathan E Page, Enwu Liu
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Publication number: 20230029030Abstract: The gene encoding N-methylputrescine oxidase (MPO) and constructs comprising such DNA are provided, including methods of regulating MPO expression independently or with other alkaloid biosynthesis genes to modulate alkaloid production in plants and host cells. MPO genes or fragments thereof are useful for reducing pyrrolidine or tropane alkaloid production in plants, for increasing pyrrolidine or tropane alkaloid production in plants, and for producing an MPO enzyme in host cells.Type: ApplicationFiled: June 22, 2022Publication date: January 26, 2023Applicant: 22nd Century Limited, LLCInventors: Jonathan E. PAGE, Enwu Liu
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Patent number: 11396656Abstract: The gene encoding N-methylputrescine oxidase (MPO) and constructs comprising such DNA are provided, including methods of regulating MPO expression independently or with other alkaloid biosynthesis genes to modulate alkaloid production in plants and host cells. MPO genes or fragments thereof are useful for reducing pyrrolidine or tropane alkaloid production in plants, for increasing pyrrolidine or tropane alkaloid production in plants, and for producing an MPO enzyme in host cells.Type: GrantFiled: May 18, 2020Date of Patent: July 26, 2022Assignee: 22nd Century Limited, LLCInventors: Jonathan E. Page, Enwu Liu
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Publication number: 20200277616Abstract: The gene encoding N-methylputrescine oxidase (MPO) and constructs comprising such DNA are provided, including methods of regulating MPO expression independently or with other alkaloid biosynthesis genes to modulate alkaloid production in plants and host cells. MPO genes or fragments thereof are useful for reducing pyrrolidine or tropane alkaloid production in plants, for increasing pyrrolidine or tropane alkaloid production in plants, and for producing an MPO enzyme in host cells.Type: ApplicationFiled: May 18, 2020Publication date: September 3, 2020Applicant: 22nd Century Limited, LLCInventors: Jonathan E. Page, Enwu Liu
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Patent number: 10689658Abstract: The gene encoding N-methylputrescine oxidase (MPO) and constructs comprising such DNA are provided, including methods of regulating MPO expression independently or with other alkaloid biosynthesis genes to modulate alkaloid production in plants and host cells. MPO genes or fragments thereof are useful for reducing pyrrolidine or tropane alkaloid production in plants, for increasing pyrrolidine or tropane alkaloid production in plants, and for producing an MPO enzyme in host cells.Type: GrantFiled: August 3, 2018Date of Patent: June 23, 2020Assignee: 22nd Century Limited, LLCInventors: Jonathan E. Page, Enwu Liu
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Publication number: 20190032069Abstract: The gene encoding N-methylputrescine oxidase (MPO) and constructs comprising such DNA are provided, including methods of regulating MPO expression independently or with other alkaloid biosynthesis genes to modulate alkaloid production in plants and host cells. MPO genes or fragments thereof are useful for reducing pyrrolidine or tropane alkaloid production in plants, for increasing pyrrolidine or tropane alkaloid production in plants, and for producing an MPO enzyme in host cells.Type: ApplicationFiled: August 3, 2018Publication date: January 31, 2019Applicant: 22ND CENTURY LIMITED, LLCInventors: JONATHAN E. PAGE, ENWU LIU
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Patent number: 10041084Abstract: The gene encoding N-methylputrescine oxidase (MPO) and constructs comprising such DNA are provided, including methods of regulating MPO expression independently or with other alkaloid biosynthesis genes to modulate alkaloid production in plants and host cells. MPO genes or fragments thereof are useful for reducing pyrrolidine or tropane alkaloid production in plants, for increasing pyrrolidine or tropane alkaloid production in plants, and for producing an MPO enzyme in host cells.Type: GrantFiled: August 19, 2016Date of Patent: August 7, 2018Assignee: 22nd Century Limited, LLCInventors: Jonathan E. Page, Enwu Liu
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Publication number: 20170044564Abstract: The gene encoding N-methylputrescine oxidase (MPO) and constructs comprising such DNA are provided, including methods of regulating MPO expression independently or with other alkaloid biosynthesis genes to modulate alkaloid production in plants and host cells. MPO genes or fragments thereof are useful for reducing pyrrolidine or tropane alkaloid production in plants, for increasing pyrrolidine or tropane alkaloid production in plants, and for producing an MPO enzyme in host cells.Type: ApplicationFiled: August 19, 2016Publication date: February 16, 2017Applicant: 22nd Century Limited, LLCInventors: Jonathan E. Page, Enwu Liu
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Patent number: 9422533Abstract: The gene encoding N-methylputrescine oxidase (MPO) and constructs comprising such DNA are provided, including methods of regulating MPO expression independently or with other alkaloid biosynthesis genes to modulate alkaloid production in plants and host cells. MPO genes or fragments thereof are useful for reducing pyrrolidine or tropane alkaloid production in plants, for increasing pyrrolidine or tropane alkaloid production in plants, and for producing an MPO enzyme in host cells.Type: GrantFiled: February 22, 2013Date of Patent: August 23, 2016Assignee: 22nd Century Limited, LLCInventors: Jonathan E. Page, Enwu Liu
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Patent number: 9422532Abstract: The gene encoding N-methylputrescine oxidase (MPO) and constructs comprising such DNA are provided, including methods of regulating MPO expression independently or with other alkaloid biosynthesis genes to modulate alkaloid production in plants and host cells. MPO genes or fragments thereof are useful for reducing pyrrolidine or tropane alkaloid production in plants, for increasing pyrrolidine or tropane alkaloid production in plants, and for producing an MPO enzyme in host cells.Type: GrantFiled: February 22, 2013Date of Patent: August 23, 2016Assignee: 22nd Century Limited, LLCInventors: Jonathan E. Page, Enwu Liu
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Patent number: 8618355Abstract: Nucleic acid molecules from hop (Humulus lupulus) have been isolated and characterized wherein said nucleic acid molecules encode polypeptides having aromatic prenyltransferase activity Expression or over-expression of said nucleic acid molecules alters the level of terpenophenolic compounds The polypeptides may be used in vivo or in vitro to produce terpenophenolic compounds (e g, prenylated acylphloroglucmols and prenylflavonoids) such as prenyl-PIVP, prenyl-PIBP, humulone, lupulone, desmethylxanthohumol and xanthohumol.Type: GrantFiled: March 16, 2009Date of Patent: December 31, 2013Assignee: National Research Council of CanadaInventors: Jonathan Page, Enwu Liu, Jana Nagel
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Patent number: 8410341Abstract: The gene encoding N-methylputrescine oxidase (MPO) and constructs comprising such DNA are provided, including methods of regulating MPO expression independently or with other alkaloid biosynthesis genes to modulate alkaloid production in plants and host cells. MPO genes or fragments thereof are useful for reducing pyrrolidine or tropane alkaloid production in plants, for increasing pyrrolidine or tropane alkaloid production in plants, and for producing an MPO enzyme in host cells.Type: GrantFiled: June 19, 2007Date of Patent: April 2, 2013Assignee: National Research Council of CanadaInventors: Jonathan E. Page, Enwu Liu
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Publication number: 20110021610Abstract: Nucleic acid molecules from hop (Humulus lupulus) have been isolated and characterized wherein said nucleic acid molecules encode polypeptides having aromatic prenyltransferase activity Expression or over-expression of said nucleic acid molecules alters the level of terpenophenolic compounds The polypeptides may be used in vivo or in vitro to produce terpenophenolic compounds (e g, prenylated acylphloroglucmols and prenylflavonoids) such as prenyl-PIVP, prenyl-PIBP, humulone, lupulone, desmethylxanthohumol and xanthohumolType: ApplicationFiled: March 16, 2009Publication date: January 27, 2011Applicant: NATIONAL RESEARCH COUNCIL OF CANADAInventors: Jonathan Page, Enwu Liu, Jana Nagel
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Publication number: 20090210958Abstract: The gene encoding N-methylputrescine oxidase (MPO) and constructs comprising such DNA are provided, including methods of regulating MPO expression independently or with other alkaloid biosynthesis genes to modulate alkaloid production in plants and host cells. MPO genes or fragments thereof are useful for reducing pyrrolidine or tropane alkaloid production in plants, for increasing pyrrolidine or tropane alkaloid production in plants, and for producing an MPO enzyme in host cells.Type: ApplicationFiled: June 19, 2007Publication date: August 20, 2009Inventors: Jonathan E. Page, Enwu Liu
