Patents by Inventor Enyu Imai

Enyu Imai has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method of gene transfer via vascular system or ureter
    Patent number: 8263756
    Abstract: The present invention provides a method for gene transfer through the vascular system or a ureter. In a preferable embodiment of this invention, an aqueous solution containing an expression vector comprising a desired gene is injected through the vascular system or a ureter of a desired organ to introduce the gene into the injected area. Specifically, the method of the present invention is effective for ex vivo gene therapy wherein the hepatocyte growth factor (HGF) gene is introduced by electroporation into a kidney to be transplanted. According to the present invention, the HGF functions continuously on the kidney to be transplanted, and the HGF within the treated area does not affect other organs of the body. Thus, the method of the present invention is a safe and effective treatment for maintaining the survival of transplanted kidneys.
    Type: Grant
    Filed: March 22, 2002
    Date of Patent: September 11, 2012
    Assignee: Chugai Seiyaku Kabushiki Kaisha
    Inventors: Shiro Takahara, Enyu Imai, Yoshitaka Isaka
  • Method of gene transfer via vascular system or ureter
    Publication number: 20040175370
    Abstract: The present invention provides a method for gene transfer through the vascular system or a ureter. In a preferable embodiment of this invention, an aqueous solution containing an expression vector comprising a desired gene is injected through the vascular system or a ureter of a desired organ to introduce the gene into the injected area. Specifically, the method of the present invention is effective for ex vivo gene therapy wherein the hepatocyte growth factor (HGF) gene is introduced by electroporation into a kidney to be transplanted. According to the present invention, the HGF functions continuously on the kidney to be transplanted, and the HGF within the treated area does not affect other organs of the body. Thus, the method of the present invention is a safe and effective treatment for maintaining the survival of transplanted kidneys.
    Type: Application
    Filed: April 23, 2004
    Publication date: September 9, 2004
    Inventors: Shiro Takahara, Enyu Imai, Yoshitaka Isaka
  • Preventives/remedies for kidney diseases
    Patent number: 6720341
    Abstract: A compound having a Rho kinase inhibitory activity, such as (+)-trans-4-(1-aminoethyl)-1-(4-pyridylcarbamoyl)-cyclohexane, has a renal interstitial fibrosis inhibitory action in renal interstitial fibrosis model mice and various other actions, and therefore, is useful as an agent for the prophylaxis or treatment of renal diseases.
    Type: Grant
    Filed: October 17, 2002
    Date of Patent: April 13, 2004
    Assignee: Mitsubishi Pharma Corporation
    Inventors: Toshiki Moriyama, Enyu Imai
  • Virus vector for transferring gene into renal cells
    Publication number: 20030170897
    Abstract: The present invention provides a viral vector that ensures highly efficient gene transfer into renal cells and its use. The use of a Paramyxovirus vector enables gene transfer into renal cells with high efficiency. The gene transferred by in vivo administration can be continuously expressed in the renal cells over a prolonged period. The vector of the present invention is suitably used in gene therapy for kidney.
    Type: Application
    Filed: April 10, 2003
    Publication date: September 11, 2003
    Inventors: Enyu Imai, Yoshitaka Isaka, Masayuki Fukumura, Mamoru Hasegawa
  • Preventives/remedies for kidney diseases
    Publication number: 20030096843
    Abstract: A compound having a Rho kinase inhibitory activity, such as (+)-trans-4-(1-aminoethyl)-1-(4-pyridylcarbamoyl)-cyclohexane, has a renal interstitial fibrosis inhibitory action in renal interstitial fibrosis model mice and various other actions, and therefore, is useful as an agent for the prophylaxis or treatment of renal diseases.
    Type: Application
    Filed: October 17, 2002
    Publication date: May 22, 2003
    Inventors: Toshiki Moriyama, Enyu Imai