Patents by Inventor Ephraim Heller

Ephraim Heller has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20220000823
    Abstract: The invention features a pharmaceutical suspension containing drug particles, a drug delivery device anchored in the mouth for continuously administering the pharmaceutical suspension, and methods of their use.
    Type: Application
    Filed: September 21, 2021
    Publication date: January 6, 2022
    Inventors: Adam HELLER, Ephraim HELLER, John SPIRIDIGLIOZZI, Steven DIIANNI, Karl Göran WESTERBERG
  • Patent number: 11135191
    Abstract: The invention features a pharmaceutical suspension containing drug particles, a drug delivery device anchored in the mouth for continuously administering the pharmaceutical suspension, and methods of their use.
    Type: Grant
    Filed: September 24, 2020
    Date of Patent: October 5, 2021
    Assignee: SynAgile Corporation
    Inventors: Adam Heller, Ephraim Heller, John Spiridigliozzi, Steven Diianni, Evangelos C. Eleftheriou
  • Publication number: 20210267739
    Abstract: The invention features a drug delivery device held in the mouth and continuously administering either a fluid comprising drug dissolved and/or dispersed in water or in a non-toxic liquid, or a drug in solid form.
    Type: Application
    Filed: October 6, 2020
    Publication date: September 2, 2021
    Inventors: Ephraim HELLER, Adam HELLER, Bruce REHLAENDER, John SPIRIDIGLIOZZI
  • Publication number: 20210000776
    Abstract: The invention features a pharmaceutical suspension containing drug particles, a drug delivery device anchored in the mouth for continuously administering the pharmaceutical suspension, and methods of their use.
    Type: Application
    Filed: September 24, 2020
    Publication date: January 7, 2021
    Inventors: Adam HELLER, Ephraim HELLER, Karl Göran WESTERBERG, John SPIRIDIGLIOZZI
  • Publication number: 20200215012
    Abstract: The invention features a pharmaceutical suspension containing drug particles, a drug delivery device anchored in the mouth for continuously administering the pharmaceutical suspension, and methods of their use.
    Type: Application
    Filed: March 13, 2020
    Publication date: July 9, 2020
    Inventors: Adam HELLER, Ephraim HELLER, Karl Göran WESTERBERG, John SPIRIDIGLIOZZI
  • Publication number: 20190365687
    Abstract: The invention features a pharmaceutical suspension containing drug particles, a drug delivery device anchored in the mouth for continuously administering the pharmaceutical suspension, and methods of their use.
    Type: Application
    Filed: June 10, 2019
    Publication date: December 5, 2019
    Inventors: Adam HELLER, Ephraim HELLER, Karl Göran WESTERBERG, John SPIRIDIGLIOZZI
  • Publication number: 20190117605
    Abstract: The invention features a pharmaceutical suspension containing drug particles, a drug delivery device anchored in the mouth for continuously administering the pharmaceutical suspension, and methods of their use.
    Type: Application
    Filed: December 14, 2018
    Publication date: April 25, 2019
    Inventors: Adam HELLER, Ephraim HELLER, Karl Göran WESTERBERG, John SPIRIDIGLIOZZI
  • Publication number: 20180177752
    Abstract: The invention features a pharmaceutical suspension containing drug particles, a drug delivery device anchored in the mouth for continuously administering the pharmaceutical suspension, and methods of their use.
    Type: Application
    Filed: February 2, 2018
    Publication date: June 28, 2018
    Inventors: Adam HELLER, Ephraim HELLER, Karl Göran WESTERBERG, John SPIRIDIGLIOZZI
  • Publication number: 20180128767
    Abstract: A sensor utilizing a non-leachable or diffusible redox mediator is described. The sensor includes a sample chamber to hold a sample in electrolytic contact with a working electrode, and in at least some instances, the sensor also contains a non-leachable or a diffusible second electron transfer agent. The sensor and/or the methods used produce a sensor signal in response to the analyte that can be distinguished from a background signal caused by the mediator. The invention can be used to determine the concentration of a biomolecule, such as glucose or lactate, in a biological fluid, such as blood or serum, using techniques such as coulometry, amperometry, and potentiometry. An enzyme capable of catalyzing the electrooxidation or electroreduction of the biomolecule is typically provided as a second electron transfer agent.
    Type: Application
    Filed: January 3, 2018
    Publication date: May 10, 2018
    Applicant: Abbott Diabetes Care Inc.
    Inventors: Benajmin J. Feldman, Adam Heller, Ephraim Heller, Fei Mao, Joseph A. Vivolo, Jeffery V. Funderburk, Fredric C. Colman, Rajesh Krishnan
  • Patent number: 9901561
    Abstract: The invention features a pharmaceutical suspension containing drug particles, a drug delivery device anchored in the mouth for continuously administering the pharmaceutical suspension, and methods of their use.
    Type: Grant
    Filed: March 2, 2017
    Date of Patent: February 27, 2018
    Assignee: SynAgile Corporation
    Inventors: Adam Heller, Ephraim Heller, Karl Göran Westerberg, John Spiridigliozzi
  • Patent number: 9891185
    Abstract: A sensor utilizing a non-leachable or diffusible redox mediator is described. The sensor includes a sample chamber to hold a sample in electrolytic contact with a working electrode, and in at least some instances, the sensor also contains a non-leachable or a diffusible second electron transfer agent. The sensor and/or the methods used produce a sensor signal in response to the analyte that can be distinguished from a background signal caused by the mediator. The invention can be used to determine the concentration of a biomolecule, such as glucose or lactate, in a biological fluid, such as blood or serum, using techniques such as coulometry, amperometry, and potentiometry. An enzyme capable of catalyzing the electrooxidation or electroreduction of the biomolecule is typically provided as a second electron transfer agent.
    Type: Grant
    Filed: May 16, 2016
    Date of Patent: February 13, 2018
    Assignee: Abbott Diabetes Care Inc.
    Inventors: Benjamin J. Feldman, Adam Heller, Ephraim Heller, Fei Mao, Joseph A. Vivolo, Jeffery V. Funderburk, Fredric C. Colman, Rajesh Krishnan
  • Publication number: 20170172961
    Abstract: The invention features a pharmaceutical suspension containing drug particles, a drug delivery device anchored in the mouth for continuously administering the pharmaceutical suspension, and methods of their use.
    Type: Application
    Filed: March 2, 2017
    Publication date: June 22, 2017
    Inventors: Adam HELLER, Ephraim HELLER, Karl Göran WESTERBERG, John SPIRIDIGLIOZZI
  • Publication number: 20160334356
    Abstract: A sensor utilizing a non-leachable or diffusible redox mediator is described. The sensor includes a sample chamber to hold a sample in electrolytic contact with a working electrode, and in at least some instances, the sensor also contains a non-leachable or a diffusible second electron transfer agent. The sensor and/or the methods used produce a sensor signal in response to the analyte that can be distinguished from a background signal caused by the mediator. The invention can be used to determine the concentration of a biomolecule, such as glucose or lactate, in a biological fluid, such as blood or serum, using techniques such as coulometry, amperometry, and potentiometry. An enzyme capable of catalyzing the electrooxidation or electroreduction of the biomolecule is typically provided as a second electron transfer agent.
    Type: Application
    Filed: May 16, 2016
    Publication date: November 17, 2016
    Inventors: Benjamin J. Feldman, Adam Heller, Ephraim Heller, Fei Mao, Joseph A. Vivolo, Jeffery V. Funderburk, Fredric C. Colman, Rajesh Krishnan
  • Publication number: 20160278899
    Abstract: The invention features a drug delivery device held in the mouth and continuously administering either a fluid comprising drug dissolved and/or dispersed in water or in a non-toxic liquid, or a drug in solid form.
    Type: Application
    Filed: November 5, 2014
    Publication date: September 29, 2016
    Inventors: Ephraim HELLER, Adam HELLER, Bruce REHLAENDER, John SPIRIDIGLIOZZI
  • Patent number: 9341591
    Abstract: A sensor utilizing a non-leachable or diffusible redox mediator is described. The sensor includes a sample chamber to hold a sample in electrolytic contact with a working electrode, and in at least some instances, the sensor also contains a non-leachable or a diffusible second electron transfer agent. The sensor and/or the methods used produce a sensor signal in response to the analyte that can be distinguished from a background signal caused by the mediator. The invention can be used to determine the concentration of a biomolecule, such as glucose or lactate, in a biological fluid, such as blood or serum, using techniques such as coulometry, amperometry, and potentiometry. An enzyme capable of catalyzing the electrooxidation or electroreduction of the biomolecule is typically provided as a second electron transfer agent.
    Type: Grant
    Filed: May 19, 2014
    Date of Patent: May 17, 2016
    Assignee: Abbott Diabetes Care Inc.
    Inventors: Benjamin J. Feldman, Adam Heller, Ephraim Heller, Fei Mao, Joseph A. Vivolo, Jeffery V. Funderburk, Fredric C. Colman, Rajesh Krishnan
  • Patent number: 9326714
    Abstract: An analyte monitor includes a sensor, a sensor control unit, and a display unit. The sensor has, for example, a substrate, a recessed channel formed in the substrate, and conductive material disposed in the recessed channel to form a working electrode. The sensor control unit typically has a housing adapted for placement on skin and is adapted to receive a portion of an electrochemical sensor. The sensor control unit also includes two or more conductive contacts disposed on the housing and configured for coupling to two or more contact pads on the sensor. A transmitter is disposed in the housing and coupled to the plurality of conductive contacts for transmitting data obtained using the sensor. The display unit has a receiver for receiving data transmitted by the transmitter of the sensor control unit and a display coupled to the receiver for displaying an indication of a level of an analyte.
    Type: Grant
    Filed: June 29, 2010
    Date of Patent: May 3, 2016
    Assignee: Abbott Diabetes Care Inc.
    Inventors: James Say, Michael F. Tomasco, Adam Heller, Yoram Gal, Behrad Aria, Ephraim Heller, Phillip John Plante, Mark S. Vreeke, Keith A. Friedman, Fredric C. Colman
  • Patent number: 9316609
    Abstract: A sensor utilizing a non-leachable or diffusible redox mediator is described. The sensor includes a sample chamber to hold a sample in electrolytic contact with a working electrode, and in at least some instances, the sensor also contains a non-leachable or a diffusible second electron transfer agent. The sensor and/or the methods used produce a sensor signal in response to the analyte that can be distinguished from a background signal caused by the mediator. The invention can be used to determine the concentration of a biomolecule, such as glucose or lactate, in a biological fluid, such as blood or serum, using techniques such as coulometry, amperometry, and potentiometry. An enzyme capable of catalyzing the electrooxidation or electroreduction of the biomolecule is typically provided as a second electron transfer agent.
    Type: Grant
    Filed: May 19, 2014
    Date of Patent: April 19, 2016
    Assignee: Abbott Diabetes Care Inc.
    Inventors: Benjamin J. Feldman, Adam Heller, Ephraim Heller, Fei Mao, Joseph A. Vivolo, Jeffery V. Funderburk, Fredric C. Colman, Rajesh Krishnan
  • Patent number: 9291592
    Abstract: A sensor utilizing a non-leachable or diffusible redox mediator is described. The sensor includes a sample chamber to hold a sample in electrolytic contact with a working electrode, and in at least some instances, the sensor also contains a non-leachable or a diffusible second electron transfer agent. The sensor and/or the methods used produce a sensor signal in response to the analyte that can be distinguished from a background signal caused by the mediator. The invention can be used to determine the concentration of a biomolecule, such as glucose or lactate, in a biological fluid, such as blood or serum, using techniques such as coulometry, amperometry, and potentiometry. An enzyme capable of catalyzing the electrooxidation or electroreduction of the biomolecule is typically provided as a second electron transfer agent.
    Type: Grant
    Filed: May 19, 2014
    Date of Patent: March 22, 2016
    Assignee: Abbott Diabetes Care Inc.
    Inventors: Benjamin J. Feldman, Adam Heller, Ephraim Heller, Fei Mao, Joseph A. Vivolo, Jeffery V. Funderburk, Fredric C. Colman, Rajesh Krishnan
  • Patent number: 9234863
    Abstract: A sensor utilizing a non-leachable or diffusible redox mediator is described. The sensor includes a sample chamber to hold a sample in electrolytic contact with a working electrode, and in at least some instances, the sensor also contains a non-leachable or a diffusible second electron transfer agent. The sensor and/or the methods used produce a sensor signal in response to the analyte that can be distinguished from a background signal caused by the mediator. The invention can be used to determine the concentration of a biomolecule, such as glucose or lactate, in a biological fluid, such as blood or serum, using techniques such as coulometry, amperometry, and potentiometry. An enzyme capable of catalyzing the electrooxidation or electroreduction of the biomolecule is typically provided as a second electron transfer agent.
    Type: Grant
    Filed: May 19, 2014
    Date of Patent: January 12, 2016
    Assignee: Abbott Diabetes Care Inc.
    Inventors: Benjamin J. Feldman, Adam Heller, Ephraim Heller, Fei Mao, Joseph A. Vivolo, Jeffery V. Funderburk, Fredric C. Colman, Rajesh Krishnan
  • Publication number: 20150217046
    Abstract: The invention features methods, compositions, dosing regimens, and infusion pumps for subcutaneously infusing acidic solutions of L-DOPA prodrugs, such as esters and amides of L-DOPA, for the treatment of Parkinson's disease. The methods and acidic compositions of the invention can reduce the severity and rate of occurrence of transient local swelling, erythema, and persistent subcutaneous granulomas associated with subcutaneous delivery of certain agents used in the treatment of Parkinson's disease.
    Type: Application
    Filed: June 4, 2013
    Publication date: August 6, 2015
    Inventors: Adam Heller, Ephraim Heller