Abstract: An annular water removal system (AWRS) for an air cycle environmental control system (ECS) includes a line replaceable unit (LRU) configured to output air flow, and a water collector coupled to the LRU. The water collector includes an upper portion and a lower portion. The upper portion includes a coalescing unit having a collector inlet to receive the air flow and configured to coalesce moisture from the air flow output from the LRU. The lower portion includes a collection unit in fluid communication with the coalescing unit. The collection unit is configured to collect the moisture coalesced by the coalescing unit.

Abstract: An annular water removal system (AWRS) for an air cycle environmental control system (ECS) includes a line replaceable unit (LRU) configured to output air flow, and a water collector coupled to the LRU. The water collector includes an upper portion and a lower portion. The upper portion includes a coalescing unit having a collector inlet to receive the air flow and configured to coalesce moisture from the air flow output from the LRU. The lower portion includes a collection unit in fluid communication with the coalescing unit. The collection unit is configured to collect the moisture coalesced by the coalescing unit.

Abstract: A heat exchanger includes a header and an annular core fluidly connected to the header. The annular core includes an inner diameter, an outer diameter, first flow channels arranged in a first set of layers, and second flow channels arranged in a second set of layers and interleaved with the first flow channels. Each of the first flow channels includes a first inlet, a first outlet, and a first axial region extending between the first inlet and the first outlet. Each of the second flow channels includes a second inlet, a second outlet, and a second axial region extending between the second inlet and the second outlet.

Abstract: A heat exchanger includes a first flow circuit structure having at least a first portion defined by a plurality of conduits and a second flow circuit structure having at least a second portion disposed at the first portion such that walls of the second portion are disposed between the conduits and are free to move relative to the conduits. Fluid flowing through the first flow circuit structure is fluidically isolated from fluid flowing through the second flow circuit structure.

Abstract: The invention provides methods and compositions for administration of allogeneic lymphocytes as an exogenous source of CD4+ T cell help for endogenous, tumor-reactive CD8+ T cells.

Abstract: A heat exchanger includes a first fluid manifold extending along a first fluid axis from a first fluid inlet to a first fluid outlet. The first fluid manifold comprises a inlet header, a outlet header, and a multi-helical core section. The inlet header is disposed to fork the first fluid inlet into a plurality of first fluid branches distributed laterally across a plane normal to the first fluid axis. The outlet header is disposed to combine the plurality of first fluid branches into the first fluid outlet. The multi-helical core section fluidly connects the inlet header to the outlet header via a plurality of laterally distributed helical tubes, each helical tube corresponding to one of the plurality of first fluid branches and oriented parallel to all others of the plurality of helical tubes at each axial location along the first fluid axis.

Abstract: The invention provides methods and compositions for administration of allogeneic lymphocytes as an exogenous source of CD4+ T cell help for endogenous, tumor-reactive CD8+ T cells. Depletion of CD8+ T cells from the donor lymphocyte infusion reduces the risk of sustained engraftment and graft-versus-host disease. Removal of regulatory T cells from the infused population may augment the ability of non-regulatory T cells to provide help for endogenous effectors of anti-tumor immunity. Allogeneic T cell therapy is typically given in the context of allogeneic stem cell transplantation, in which the patient receives highly immunosuppressive conditioning followed by an infusion of a stem cell graft containing unselected populations of mature T cells. In the treatment described here, the graft is engineered to minimize the possibility of sustained donor cell engraftment, and the anti-tumor effector T cells derive from the host.

Abstract: A heat exchanger includes a first fluid manifold extending along a first fluid axis from a first fluid inlet to a first fluid outlet. The first fluid manifold includes a first fluid inlet header, a first fluid outlet header, and a nested helical core section. The first fluid inlet header is disposed to fork the first fluid inlet into a plurality of first fluid branches distributed circumferentially and radially about the first fluid axis. The first fluid outlet header is disposed to combine the plurality of first fluid branches into the first fluid outlet. The nested helical core section fluidly connects the first fluid inlet header to the first fluid outlet header via a plurality of nested helical tubes, and includes radially inner and outer groups of circumferentially distributed helical tubes.

Abstract: A heat exchanger header for receiving a first fluid includes a tubular primary fluid channel oriented along a first axis and having a first cross-sectional area. A first branched region adjacent to the primary fluid channel fluidly connects to a plurality of tubular secondary fluid channels, each having a second cross-sectional area, and a second branched region adjacent to each of the secondary fluid channels fluidly connects to a plurality of tubular tertiary fluid channels, each having a third cross-sectional area. The second cross-sectional area is greater than the third cross-sectional area.

Abstract: An annular water removal system (AWRS) for an air cycle environmental control system (ECS) includes a line replaceable unit (LRU) configured to output air flow, and a water collector coupled to the LRU. The water collector includes an upper portion and a lower portion. The upper portion includes a coalescing unit having a collector inlet to receive the air flow and configured to coalesce moisture from the air flow output from the LRU. The lower portion includes a collection unit in fluid communication with the coalescing unit. The collection unit is configured to collect the moisture coalesced by the coalescing unit.

Abstract: A heat exchanger includes a header and an annular core fluidly connected to the header. The annular core includes an inner diameter, an outer diameter, first flow channels arranged in a first set of layers, and second flow channels arranged in a second set of layers and interleaved with the first flow channels. Each of the first flow channels includes a first inlet, a first outlet, and a first axial region extending between the first inlet and the first outlet. Each of the second flow channels includes a second inlet, a second outlet, and a second axial region extending between the second inlet and the second outlet.

Abstract: A core arrangement for a heat exchanger includes a plurality of inlets arranged around an axis, a plurality of outlets arranged around the axis, and a plurality of bowed conduits arranged around the axis. The bowed conduits are structurally independent, connect the plurality of inlets to the plurality of outlets, bow outward from the axis between the plurality of inlets and the plurality of outlets, and provide thermal compliance to the core.

Abstract: A core arrangement for a heat exchanger includes a first core layer disposed along a first plane and having an inlet and outlet oriented along a first axis within the first plane and a first core stage disposed in fluid communication between the inlet and the outlet. The first core stage includes a first upstream fluid intersection downstream of and adjacent the inlet and having a first inlet continuation and a first bifurcation. The first core stage further includes a first downstream fluid intersection upstream of and adjacent the outlet and having a first outlet continuation and a first recombination. A plurality of first core tubes fluidly connect the first bifurcation to the first recombination. The first core layer further includes a second core stage disposed in fluid communication between the first inlet continuation and the first outlet continuation.

Abstract: A heat exchanger header for receiving a first fluid includes a tubular primary fluid channel oriented along a first axis and having a first cross-sectional area. A first branched region adjacent to the primary fluid channel fluidly connects to a plurality of tubular secondary fluid channels, each having a second cross-sectional area, and a second branched region adjacent to each of the secondary fluid channels fluidly connects to a plurality of tubular tertiary fluid channels, each having a third cross-sectional area. The second cross-sectional area is greater than the third cross-sectional area.

Abstract: A heat exchanger includes a first flow circuit structure having at least a first portion defined by a plurality of conduits and a second flow circuit structure having at least a second portion disposed at the first portion such that walls of the second portion are disposed between the conduits and are free to move relative to the conduits. Fluid flowing through the first flow circuit structure is fluidically isolated from fluid flowing through the second flow circuit structure.

Abstract: A heat exchanger includes a first fluid manifold extending along a first fluid axis from a first fluid inlet to a first fluid outlet. The first fluid manifold comprises a inlet header, a outlet header, and a multi-helical core section. The inlet header is disposed to fork the first fluid inlet into a plurality of first fluid branches distributed laterally across a plane normal to the first fluid axis. The outlet header is disposed to combine the plurality of first fluid branches into the first fluid outlet. The multi-helical core section fluidly connects the inlet header to the outlet header via a plurality of laterally distributed helical tubes, each helical tube corresponding to one of the plurality of first fluid branches and oriented parallel to all others of the plurality of helical tubes at each axial location along the first fluid axis.

Abstract: A heat exchanger includes a first fluid manifold extending along a first fluid axis from a first fluid inlet to a first fluid outlet. The first fluid manifold includes first fluid inlet and outlet headers, and a helical core section. The inlet header is disposed to branch the first fluid inlet into a plurality of first fluid branches, and the outlet header is disposed to combine the plurality of first fluid branches into the first fluid outlet. The core section fluidly connects the inlet header to the outlet header via a plurality of helical tubes, such that each helical tube corresponds to one of the plurality of first fluid branches.

Abstract: A heat exchanger includes a first fluid manifold extending along a first fluid axis from a first fluid inlet to a first fluid outlet. The first fluid manifold includes a first fluid inlet header, a first fluid outlet header, and a nested helical core section. The first fluid inlet header is disposed to fork the first fluid inlet into a plurality of first fluid branches distributed circumferentially and radially about the first fluid axis. The first fluid outlet header is disposed to combine the plurality of first fluid branches into the first fluid outlet. The nested helical core section fluidly connects the first fluid inlet header to the first fluid outlet header via a plurality of nested helical tubes, and includes radially inner and outer groups of circumferentially distributed helical tubes.

Abstract: A core arrangement for a heat exchanger includes a plurality of inlets arranged around an axis, a plurality of outlets arranged around the axis, and a plurality of bowed conduits arranged around the axis. The bowed conduits are structurally independent, connect the plurality of inlets to the plurality of outlets, bow outward from the axis between the plurality of inlets and the plurality of outlets, and provide thermal compliance to the core.

Abstract: A core arrangement for a heat exchanger includes a first core layer disposed along a first plane and having an inlet and outlet oriented along a first axis within the first plane and a first core stage disposed in fluid communication between the inlet and the outlet. The first core stage includes a first upstream fluid intersection downstream of and adjacent the inlet and having a first inlet continuation and a first bifurcation. The first core stage further includes a first downstream fluid intersection upstream of and adjacent the outlet and having a first outlet continuation and a first recombination. A plurality of first core tubes fluidly connect the first bifurcation to the first recombination. The first core layer further includes a second core stage disposed in fluid communication between the first inlet continuation and the first outlet continuation.