Patents by Inventor Epp Songisepp

Epp Songisepp has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20230330161
    Abstract: The microorganism strain Pediococcus acidilactici TAK 589 CoccobEst is a new antimicrobial and antioxidant probiotic, CoccobEst inhibits the growth of the enteropathogens L. monocytogenes, E. coli, S. enteritidis, S. typhimurium, S. sonnei, S. aureus, E. faecalis and C. sakazakii, but does not inhibit lactobacilli of natural intestinal microbiota. The strain's antimicrobial properties are enhanced by periplasmic peptidoglycan hydrolases with proteolytic activity. CoccobEst is used as a zootechnieai feed additive to prevent bacterial infections in the gastrointestinal tract of farm animals and pets and to prevent and reduce diarrhea. CoccobEst has highly active antioxidant defense system, increasing the redox activity of glutathione and reducing oxidative stress in cells. Therefore, CoccobEst is used as a food supplement or functional food for humans to prevent bacterial infections of the gastrointestinal tract and to prevent and reduce oxidative stress.
    Type: Application
    Filed: September 17, 2021
    Publication date: October 19, 2023
    Inventors: Pille KALLAKMAA, Tanel KAART, Kristiina MÄRS, Meelis OTS, Eve RIHMA, Jaan VIHALEMM, Epp SONGISEPP, Liina KUUS, Heili SADAM
  • Patent number: 10272122
    Abstract: A microorganism strain Lactobacillus plantarum Inducia DSM 21379 for use as hypocholesterolemic, antimicrobial and anti-oxidative agent and as enhancer of the natural defense potential of a subject. L. plantarum Inducia is used for reducing the level of LDL-cholesterol in blood for preventing the cholesterol metabolism disorders and cardiovascular disorders. L. plantarum Inducia enhances simultaneously the natural defense potential and cellular immunity, and as anti-oxidative agent enhances anti-oxidative activity of blood by reducing the level of oxidized low density lipoprotein (ox-LDL). The strain is also used as an antimicrobial agent for lowering risk of Clostridium difficile associated diarrhea (CDAD) by preventing germination of C. difficile spores and by suppressing proliferation of its vegetative cells. The compositions comprising L. plantarum Inducia decrease the levels of LDL-cholesterol and ox-LDL in blood, enhance the natural defense potential and lower risk of CDAD.
    Type: Grant
    Filed: April 19, 2016
    Date of Patent: April 30, 2019
    Assignee: BIOCC OÜ
    Inventors: Marika Mikelsaar, Epp Songisepp, Pirje Hütt, Imbi Smidt, Kai Truusalu, Merle Rätsep, Siiri Koljalg, Jelena Stsepetova, Kalle Kilk, Mihkel Zilmer, Epp Sepp, Raik-Hiio Mikelsaar
  • Publication number: 20160296570
    Abstract: A microorganism strain Lactobacillus plantarum Inducia DSM 21379 for use as hypocholesterolemic, antimicrobial and anti-oxidative agent and as enhancer of the natural defense potential of a subject. L. plantarum Inducia is used for reducing the level of LDL-cholesterol in blood for preventing the cholesterol metabolism disorders and cardiovascular disorders. L. plantarum Inducia enhances simultaneously the natural defense potential and cellular immunity, and as anti-oxidative agent enhances anti-oxidative activity of blood by reducing the level of oxidized low density lipoprotein (ox-LDL). The strain is also used as an antimicrobial agent for lowering risk of Clostridium difficile associated diarrhoeae (CDAD) by preventing germination of C. difficile spores and by suppressing proliferation of its vegetative cells. The compositions comprising L. plantarum Inducia decrease the levels of LDL-cholesterol and ox-LDL in blood, enhance the natural defense potential and lower risk of CDAD.
    Type: Application
    Filed: April 19, 2016
    Publication date: October 13, 2016
    Applicant: TERVISLIKU PllMA BIOTEHNOLOOGIATE ARENDUSKESKUS OÜ (BIO-COMPETENCE CENTRE OF
    Inventors: Marika Mikelsaar, Epp Songisepp, Pirje Hütt, lmbi Smidt, Kai Truusalu, Merle Rätsep, Siiri Koljalg, Jelena Stsepetova, Kalle Kilk, Mihkel Zilmer, Epp Sepp, Raik-Hiio Mikelsaar
  • Publication number: 20140335066
    Abstract: A microorganism strain Lactobacillus plantarum Inducia DSM 21379 for use as hypocholesterolemic, antimicrobial and anti-oxidative agent and as enhancer of the natural defense potential of a subject. L. plantarum Inducia is used for reducing the level of LDL-cholesterol in blood for preventing the cholesterol metabolism disorders and cardiovascular disorders. L. plantarum Inducia enhances simultaneously the natural defense potential and cellular immunity, and as anti-oxidative agent enhances anti-oxidative activity of blood by reducing the level of oxidized low density lipoprotein (ox-LDL). The strain is also used as an antimicrobial agent for lowering risk of Clostridium difficile associated diarrhoeae (CDAD) by preventing germination of C. difficile spores and by suppressing proliferation of its vegetative cells. The compositions comprising L. plantarum Inducia decrease the levels of LDL-cholesterol and ox-LDL in blood, enhance the natural defense potential and lower risk of CDAD.
    Type: Application
    Filed: April 3, 2014
    Publication date: November 13, 2014
    Applicant: TERVISLIKU PIIMA BIOTEHNOLOOGIATE ARENDUSKESKUS OÜ (BIO-COMPETENCE CENTRE OF
    Inventors: Marika Mikelsaar, Epp Songisepp, Pirje Hütt, Imbi Smidt, Kai Truusalu, Merle Rätsep, Siiri Kõljalg, Jelena Stsepetova, Kalle Kilk, Mihkel Zilmer, Epp Sepp, Raik-Hiio Mikelsaar
  • Publication number: 20140328814
    Abstract: The present invention relates to an antimicrobial and antihypertensive probiotic compositions comprising microorganism strain Lactobacillus plantarum Tensia DSM 21380, e.g. food or pharmaceutical compositions or a dietary supplement compositions, food products (dairy products, e.g. fermented products or cheese). The invention also relates to method for suppressing pathogens and non-starter lactobacilli in food product and method for extension of shelf life of food product by the means of Lactobacillus plantarum Tensia DSM 21380.
    Type: Application
    Filed: June 12, 2014
    Publication date: November 6, 2014
    Applicant: Oü Tervisliku Piima Biotehnoloogiate Arenduskeskus (Bio-Competence Centre of
    Inventors: Epp Songisepp, Marika Mikelsaar, Merle Rätsep, Mihkel Zilmer, Pirje Hütt, Meeme Utt, Kristi Zilmer, Janne Uksti, Siiri Kõljalg
  • Publication number: 20140037792
    Abstract: The present invention relates to new microorganism strains L. plantarum MCC1 DSM 23881 and L. gasseri MCC2 DSM 23882 and their use as antioxidant proteolytic ingredients for the production of food products and dietary supplements. Food products and dietary supplements containing L. plantarum MCC1 and L. gasseri MCC2 are hypoallergenic, reduce milk allergy and lower urinary tract irritation symptoms accompanying benign prostatic hyperplasia and oxidative stress and inflammation associated with these.
    Type: Application
    Filed: February 23, 2012
    Publication date: February 6, 2014
    Applicant: Bio-Competence Centre of Healthy Dairy Products
    Inventors: Ene Tammsaar, Kersti Ehrlich, Kersti Zilmer, Lauri Bobrovski, Marika Mikelsaar, Margus Punab, Mihkel Zilmer, Maire Vasar, Merle Ratsep, Tiiu Kullisaar, Epp Songisepp, Andre Veskioja
  • Publication number: 20110274789
    Abstract: The present invention relates to a microorganism Lactobacillus plantarum strain Inducia DSM 21379 as probiotic, its functional properties, food product (e.g. cheese) and composition comprising said microorganism and use of said microorganism for production of medicine for enhancing cellular immunity. L. plantarum Inducia produces polyamines from ornithine and glutamate, nitric mono-oxide (NO) from arginine, possesses antioxidative activity and with produced polyamines, nitric mono-oxide and antioxidative compounds improves the intestinal barrier function, increases number of immunocytes in blood and induces cytokine production for enhancement of organisms' natural defense.
    Type: Application
    Filed: May 12, 2009
    Publication date: November 10, 2011
    Inventors: Marika Mikelsaar, Epp Songisepp, Imbi Smidt, Jelena Stsepetove, Pirje Hutt, Mihkel Zilmer, Kai Truusalu, Kalle Kilk
  • Publication number: 20110177198
    Abstract: The present invention relates to a microorganism strain Lactobacillus plantarum Tensia DSM 21380 as antimicrobial and antihypertensive probiotic, food products (dairy products, e.g. fermented products or cheese) and composition comprising said microorganism and use of said microorganism for production of antihypertensive medicine. The invention also relates to a method for suppressing pathogens and nonstarter lactobacilli in food product and a method for extension of shelf life of food product by the means of Lactobacillus plantarum Tensia DSM 21380.
    Type: Application
    Filed: May 12, 2009
    Publication date: July 21, 2011
    Applicant: OU Tervisliku PIIMa Biotehnologiate Arenduskeskus (Biocompetence Centre of Healthy Diary Products)
    Inventors: Epp Songisepp, Marika Mikelsaar, Merle Ratsep, Mihkel Zilmer, Pirje Hutt, Meeme Utt, Kersti Zilmer, Janne Uksti, Siiri Koljalg
  • Patent number: 7244424
    Abstract: The strain of micro-organism Lactobacillus fermentum ME-3 is a novel anti-microbial and anti-oxidative probiotic. It has a high anti-microbial effect on Escherichia coli, Shigella sonnei, Staphylococcus aureus, Salmonella typhimurium, and moderate activity against Helicobacter pylori strains. The strain of micro-organism possesses Mn-superoxide dismutase and both its lysates and intact cells have high anti-oxidative activity, increasing the glutathione red-ox ratio in blood sera and able to capture toxic hydroxyl radicals. The strain of micro-organism could be used as a probiotic for the production of functional food (yoghurt, cheese) and non-comestibles (tablets, capsules) for the prophylaxis of intestinal and uroinfections, both for the prevention and treatment of chronic diseases, caused by prolonged oxidative stress.
    Type: Grant
    Filed: June 21, 2002
    Date of Patent: July 17, 2007
    Assignee: University of Tartu
    Inventors: Marika Mikelsaar, Mihkel Zilmer, Tiiu Kullisaaar, Heidi Annuk, Epp Songisepp
  • Publication number: 20040151708
    Abstract: The strain of micro-organism Lactobacillus fermentum ME-3 is a novel anti-microbial and anti-oxidative probiotic. It has a high anti-microbial effect on Escherichia coli, Shigella sonnei, Staphylococcus aureus, Salmonella typhimurium, and moderate activity against Helicobacter pylori strains. The strain of micro-organism possesses Mn-superoxide dismutase and both its lysates and intact cells have high anti-oxidative activity, increasing the glutathione red-ox ratio in blood sera and able to capture toxic hydroxyl radicals. The strain of micro-organism could be used as a probiotic for the production of functional food (yoghurt, cheese) and non-comestibles (tablets, capsules) for the prophylaxis of intestinal and uroinfections, both for the prevention and treatment of chronic diseases, caused by prolonged oxidative stress.
    Type: Application
    Filed: December 22, 2003
    Publication date: August 5, 2004
    Inventors: Marika Mikelsaar, Mikhel Zilmer, Tiiu Kullisaaar, Heidi Annuk, Epp Songisepp