Abstract: Embodiments of the present disclosure relates to a new and improved large scale commercial manufacturing process of making bupivacaine multivesicular liposomes (MVLs). Batches of bupivacaine MVLs prepared by the new process have high yields, improved stabilities, and desired particle size distributions.

Abstract: Embodiments of the present disclosure relate to a new and improved large scale commercial manufacturing process of making bupivacaine multivesicular liposomes (MVLs). Batches of bupivacaine MVLs prepared by the new process have high yields, improved stabilities, and desired particle size distributions.

Abstract: Embodiments of the present disclosure relates to commercial manufacturing process of making bupivacaine multivesicular liposomes with improved yield and desired particle size distribution.

Abstract: Embodiments of the present disclosure relates to a new and improved large scale commercial manufacturing process of making bupivacaine multivesicular liposomes (MVLs). Batches of bupivacaine MVLs prepared by the new process have high yields, improved stabilities, and desired particle size distributions.

Abstract: Embodiments of the present disclosure relates to a new and improved large scale commercial manufacturing process of making bupivacaine multivesicular liposomes (MVLs). Batches of bupivacaine MVLs prepared by the new process have high yields, improved stabilities, and desired particle size distributions.

Abstract: Some embodiments of the present application are related to multivesicular liposome (MVL) formulations encapsulating dexamethasone or an ester or an ester salt thereof, for example, dexamethasone sodium phosphate (DSP) that may provide about 3-28 days extended release of dexamethasone. Processes of making and administering dexamethasone encapsulated multivesicular liposome formulations and their uses for treating pain or inflammation are also provided.

Abstract: Some embodiments of the present application are related to multivesicular liposome formulations comprising high concentration of bupivacaine for the purpose of preventing, treating or ameliorating pain, for example, post-surgical pain for an extended period of time. Processes of making and administering bupivacaine encapsulated multivesicular liposome formulations (BUP-MVLs) and their uses as medicaments are also provided.

Abstract: Embodiments of the present disclosure relates to a new and improved large scale commercial manufacturing process of making bupivacaine multivesicular liposomes (MVLs). Batches of bupivacaine MVLs prepared by the new process have high yields, improved stabilities, and desired particle size distributions.

Abstract: Embodiments of the present disclosure relates to a new and improved large scale commercial manufacturing process of making bupivacaine multivesicular liposomes (MVLs). Batches of bupivacaine MVLs prepared by the new process have high yields, improved stabilities, and desired particle size distributions.

Abstract: Embodiments of the present disclosure relates to commercial manufacturing process of making bupivacaine multivesicular liposomes with improved yield and desired particle size distribution.

Abstract: Embodiments of the present disclosure relates to a new and improved large scale commercial manufacturing process of making bupivacaine multivesicular liposomes (MVLs). Batches of bupivacaine MVLs prepared by the new process have high yields, improved stabilities, and desired particle size distributions.

Abstract: Embodiments of the present disclosure relates to a new and improved large scale commercial manufacturing process of making bupivacaine multivesicular liposomes (MVLs). Batches of bupivacaine MVLs prepared by the new process have high yields, improved stabilities, and desired particle size distributions.

Abstract: Some embodiments of the present application are related to multivesicular liposome formulations comprising high concentration of bupivacaine for the purpose of preventing, treating or ameliorating pain, for example, post-surgical pain for an extended period of time. Processes of making and administering bupivacaine encapsulated multivesicular liposome formulations (BUP-MVLs) and their uses as medicaments are also provided.

Abstract: Some embodiments of the present application are related to multivesicular liposome (MVL) formulations encapsulating dexamethasone or an ester or an ester salt thereof, for example, dexamethasone sodium phosphate (DSP) that may provide about 3-28 days extended release of dexamethasone. Processes of making and administering dexamethasone encapsulated multivesicular liposome formulations and their uses for treating pain or inflammation are also provided.

Abstract: An add-on brake system includes a housing accommodating a linear actuator including: an electric motor having a rotor and a stator; a nut arrangement coupled to the rotor; a linear threaded plunger associated having a first end linearly protruding from one end of the arrangement and a second end linearly protruding from an opposite end thereof; an inboard brake pad coupled to the housing; and an outboard brake pad associated with the second end, oriented transverse to the plunger. The plunger has an initial unclamped position in which the second end protrudes to an extent n1 from the other end of the arrangement, yielding a spacing S1 between the inboard and outboard brake pads, and a final clamped position in which the second end protrudes to an extent n2>n1 from the other end of the arrangement, yielding a spacing S2<S1 between the pads.

Abstract: Technologies for automatic domain model generation include a computing device that accesses an n-gram index of a web corpus. The computing device generates a semantic graph of the web corpus for a relevant domain using the n-gram index. The semantic graph includes one or more related entities that are related to a seed entity. The computing device performs similarity discovery to identify and rank contextual synonyms within the domain. The computing device maintains a domain model including intents representing actions in the domain and slots representing parameters of actions or entities in the domain. The computing device performs intent discovery to discover intents and intent patterns by analyzing the web corpus using the semantic graph. The computing device performs slot discovery to discover slots, slot patterns, and slot values by analyzing the web corpus using the semantic graph. Other embodiments are described and claimed.

Abstract: An add-on brake system includes a housing accommodating a linear actuator including: an electric motor having a rotor and a stator; a nut arrangement coupled to the rotor; a linear threaded plunger associated having a first end linearly protruding from one end of the arrangement and a second end linearly protruding from an opposite end thereof; an inboard brake pad coupled to the housing; and an outboard brake pad associated with the second end, oriented transverse to the plunger. The plunger has an initial unclamped position in which the second end protrudes to an extent n1 from the other end of the arrangement, yielding a spacing S1 between the inboard and outboard brake pads, and a final clamped position in which the second end protrudes to an extent n2>n1 from the other end of the arrangement, yielding a spacing S2<S1 between the pads.

Abstract: Technologies for automatic domain model generation include a computing device that accesses an n-gram index of a web corpus. The computing device generates a semantic graph of the web corpus for a relevant domain using the n-gram index. The semantic graph includes one or more related entities that are related to a seed entity. The computing device performs similarity discovery to identify and rank contextual synonyms within the domain. The computing device maintains a domain model including intents representing actions in the domain and slots representing parameters of actions or entities in the domain. The computing device performs intent discovery to discover intents and intent patterns by analyzing the web corpus using the semantic graph. The computing device performs slot discovery to discover slots, slot patterns, and slot values by analyzing the web corpus using the semantic graph. Other embodiments are described and claimed.