Patents by Inventor Erenius Toppo

Erenius Toppo has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Isoandrographolide-19-propionate for treatment of non-alcoholic fatty liver disease (NAFLD)
    Patent number: 10064841
    Abstract: Isoandrographolide-19-propionate for treatment of non-alcoholic fatty liver disease (NALFD) relates to the compound isoandrographolide-19-propionate (IAN-19P), having the structural formula: and pharmaceutically acceptable salts thereof. The compound is synthesized by reaction of isoandrographolide with anhydrous propionic acid in the presence of N,N?-dicyclohexylcarbodiimide and 4-dimethylaminopyridine. In vitro testing shows that isoandrographolide-19-propionate has lower toxicity than andrographolide, but has significantly high activity at a concentration of 50 ?M. IAN-19P produced normal triglyceride levels and significantly lowered lipoperoxide formation in palmitate-oleate induced steatotic HepG2 cells, and also lowered ALT leakage from the treated cells.
    Type: Grant
    Filed: January 8, 2018
    Date of Patent: September 4, 2018
    Assignee: KING SAUD UNIVERSITY
    Inventors: Naif Abdullah Al-Dhabi, Savarimuthu Ignacimuthu, P. Pandikumar, Erenius Toppo, Sylvester Darvin