Patents by Inventor Ergang Shi

Ergang Shi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • VL ANTIGEN BINDING PROTEINS EXHIBITING DISTINCT BINDING CHARACTERISTICS
    Publication number: 20240124613
    Abstract: Methods for making, identifying, isolating and/or making binding proteins that contain an immunoglobulin light chain variable domain, including a somatically hypermutated light chain variable domain, fused with a heavy chain constant region, are provided. Exemplary binding proteins specific to small molecules are also provided.
    Type: Application
    Filed: December 13, 2023
    Publication date: April 18, 2024
    Inventors: Robert Babb, Ashique Rafique, Tammy T. Huang, Ergang Shi, Lynn Macdonald, Andrew J. Murphy
  • METHODS FOR OBTAINING ANTIBODIES THAT BIND TRANSMEMBRANE PROTEINS AND CELLS THAT PRODUCE THE SAME
    Publication number: 20220195038
    Abstract: Disclosed are methods for obtaining cells that express antibodies that bind transmembrane proteins, methods for generating antibodies from such cells, antibodies to transmembrane proteins and fragments thereof, and nucleic acids encoding the antibodies. More particularly, the disclosure relates to methods for obtaining antibody-producing cells that express an antibody that binds to a transmembrane protein based on the use of lipid bilayer-membrane scaffold protein complexes to present transmembrane protein antigens to cells.
    Type: Application
    Filed: December 22, 2021
    Publication date: June 23, 2022
    Inventors: Gang Chen, Ergang Shi, Wen-Yi Lee, David Suh, Glen Farr, Robert Babb
  • VL ANTIGEN BINDING PROTEINS EXHIBITING DISTINCT BINDING CHARACTERISTICS
    Publication number: 20200377618
    Abstract: Methods for making, identifying, isolating and/or making binding proteins that contain an immunoglobulin light chain variable domain, including a somatically hypermutated light chain variable domain, fused with a heavy chain constant region, are provided. Exemplary binding proteins specific to small molecules are also provided.
    Type: Application
    Filed: August 18, 2020
    Publication date: December 3, 2020
    Inventors: Robert Babb, Ashique Rafique, Tammy T. Huang, Ergang Shi, Lynn Macdonald, Andrew J. Murphy
  • Vantigen binding proteins exhibiting distinct binding characteristics
    Patent number: 10787522
    Abstract: Methods for making, identifying, isolating and/or making binding proteins that contain an immunoglobulin light chain variable domain, including a somatically hypermutated light chain variable domain, fused with a heavy chain constant region, are provided. Exemplary binding proteins specific to small molecules are also provided.
    Type: Grant
    Filed: March 19, 2018
    Date of Patent: September 29, 2020
    Assignee: Regeneron Pharmaceuticals, Inc.
    Inventors: Robert Babb, Ashique Rafique, Tammy T. Huang, Ergang Shi, Lynn Macdonald, Andrew J. Murphy
  • VL ANTIGEN BINDING PROTEINS EXHIBITING DISTINCT BINDING CHARACTERISTICS
    Publication number: 20180273641
    Abstract: Methods for making, identifying, isolating and/or making binding proteins that contain an immunoglobulin light chain variable domain, including a somatically hypermutated light chain variable domain, fused with a heavy chain constant region, are provided. Exemplary binding proteins specific to small molecules are also provided.
    Type: Application
    Filed: March 19, 2018
    Publication date: September 27, 2018
    Inventors: Robert Babb, Ashique Rafique, Tammy T. Huang, Ergang Shi, Lynn Macdonald, Andrew J. Murphy
  • VL ANTIGEN BINDING PROTEINS EXHIBITING DISTINCT BINDING CHARACTERISTICS
    Publication number: 20150266976
    Abstract: Methods for making, identifying, isolating and/or making binding proteins that contain an immunoglobulin light chain variable domain, including a somatically hypermutated light chain variable domain, fused with a heavy chain constant region, are provided. Exemplary binding proteins specific to small molecules are also provided.
    Type: Application
    Filed: March 20, 2015
    Publication date: September 24, 2015
    Inventors: Robert Babb, Ashique Rafique, Tammy T. Huang, Ergang Shi, Lynn Macdonald, Andrew J. Murphy
  • High affinity human antibodies to human IL-4 receptor
    Patent number: 8338135
    Abstract: An isolated human antibody or antigen binding fragment thereof which binds to human interleukin-4 receptor alpha (hIL-4R?) with an affinity constant (KD) of less than 200 pM, as measured by surface plasmon resonance, is provided.
    Type: Grant
    Filed: December 2, 2011
    Date of Patent: December 25, 2012
    Assignee: Regeneron Pharmaceuticals, inc.
    Inventors: Sean Stevens, Tammy T. Huang, Joel H. Martin, Jeanette L. Fairhurst, Ashique Rafique, Marcela Torres, Kevin J. Pobursky, Raymond W. Leidich, Joan A. Windsor, Warren R. Mikulka, Diana M. Ahrens, Ergang Shi, Nicholas J. Papadopoulos
  • HIGH AFFINITY HUMAN ANTIBODIES TO HUMAN IL-4 RECEPTOR
    Publication number: 20120135010
    Abstract: An isolated human antibody or antigen binding fragment thereof which binds to human interleukin-4 receptor alpha (hIL-4R?) with an affinity constant (KD) of less than 200 pM, as measured by surface plasmon resonance, is provided.
    Type: Application
    Filed: December 2, 2011
    Publication date: May 31, 2012
    Applicant: Regeneron Pharmaceuticals, Inc.
    Inventors: Sean Stevens, Tammy T. Huang, Joel H. Martin, Jeanette L. Fairhurst, Ashique Rafique, Marcela Torres, Kevin J. Pobursky, Raymond W. Leidich, Joan A. Windsor, Warren R. Mikulka, Diana M. Ahrens, Ergang Shi, Nicholas J. Papadopoulos
  • High affinity human antibodies to human IL-4 receptor
    Patent number: 8092802
    Abstract: The present invention provides methods for treating one or more diseases or disorders which are improved, inhibited or ameliorated by reducing interleukin-4 (IL-4) activity. The methods of the invention comprise administering to a patient an antibody, or antigen-binding fragment thereof, which specifically binds to a human IL-4 receptor.
    Type: Grant
    Filed: June 23, 2010
    Date of Patent: January 10, 2012
    Assignee: Regeneron Pharmaceuticals, Inc.
    Inventors: Sean Stevens, Tammy T. Huang, Joel H. Martin, Jeanette L. Fairhurst, Ashique Rafique, Marcela Torres, Kevin J. Pobursky, Raymond W. Leidich, Joan A. Windsor, Warren R. Mikulka, Diana M. Ahrens, Ergang Shi, Nicholas J. Papadopoulos
  • HIGH AFFINITY HUMAN ANTIBODIES TO HUMAN IL-4 RECEPTOR
    Publication number: 20100291107
    Abstract: The present invention provides methods for treating one or more diseases or disorders which are improved, inhibited or ameliorated by reducing interleukin-4 (IL-4) activity. The methods of the invention comprise administering to a patient an antibody, or antigen-binding fragment thereof, which specifically binds to a human IL-4 receptor.
    Type: Application
    Filed: June 23, 2010
    Publication date: November 18, 2010
    Applicant: Regeneron Pharmaceuticals, Inc.
    Inventors: Sean Stevens, Tammy T. Huang, Joel H. Martin, Jeanette L. Fairhurst, Ashique Rafique, Marcela Torres, Kevin J. Pobursky, Raymond W. Leidich, Joan A. Windsor, Warren R. Mikulka, Diana M. Ahrens, Ergang Shi, Nicholas J. Papadopoulos
  • High affinity human antibodies to human IL-4 receptor
    Patent number: 7794717
    Abstract: The present invention provides methods for treating one or more diseases or disorders which are improved, inhibited or ameliorated by reducing interleukin-4 (IL-4) activity. The methods of the invention comprise administering to a patient an antibody, or antigen-binding fragment thereof, which specifically binds to a human IL-4 receptor.
    Type: Grant
    Filed: September 4, 2009
    Date of Patent: September 14, 2010
    Assignee: Regeneron Pharmaceuticals, Inc.
    Inventors: Sean Stevens, Tammy T. Huang, Joel H. Martin, Jeanette L. Fairhurst, Ashique Rafique, Marcela Torres, Kevin J. Pobursky, Raymond W. Leidich, Joan A. Windsor, Warren R. Mikulka, Diana M. Ahrens, Ergang Shi, Nicholas J. Papadopoulos
  • High Affinity Human Antibodies to Human IL-4 Receptor
    Publication number: 20100021476
    Abstract: The present invention provides methods for treating one or more diseases or disorders which are improved, inhibited or ameliorated by reducing interleukin-4 (IL-4) activity. The methods of the invention comprise administering to a patient an antibody, or antigen-binding fragment thereof, which specifically binds to a human IL-4 receptor.
    Type: Application
    Filed: September 4, 2009
    Publication date: January 28, 2010
    Applicant: Regeneron Pharmaceuticals, Inc.
    Inventors: Sean Stevens, Tammy T. Huang, Joel H. Martin, Jeanette L. Fairhurst, Ashique Rafique, Marcela Torres, Kevin J. Pobursky, Raymond W. Leidich, Joan A. Windsor, Warren R. Mikulka, Diana M. Ahrens, Ergang Shi, Nicholas J. Papadopoulos
  • High affinity human antibodies to human IL-4 receptor
    Patent number: 7605237
    Abstract: An isolated human antibody or antibody fragment thereof which binds to human interleukin-4 receptor alpha (hIL-4R?) with an affinity constant (KD) of less than 200 pM, as measured by surface plasmon resonance.
    Type: Grant
    Filed: October 2, 2007
    Date of Patent: October 20, 2009
    Assignee: Regeneron Pharmaceuticals, Inc.
    Inventors: Sean Stevens, Tammy T. Huang, Joel H. Martin, Jeanette L. Fairhurst, Ashique Rafique, Marcela Torres, Kevin J. Pobursky, Raymond W. Leidich, Joan A. Windsor, Warren R. Mikulka, Diana M. Ahrens, Ergang Shi, Nicholas J. Papadopoulos
  • High affinity human antibodies to human IL-4 receptor
    Publication number: 20080160035
    Abstract: An isolated human antibody or antibody fragment thereof which binds to human interleukin-4 receptor alpha (hIL-4R?) with an affinity constant (KD) of less than 200 pM, as measured by surface plasmon resonance.
    Type: Application
    Filed: October 2, 2007
    Publication date: July 3, 2008
    Inventors: Sean Stevens, Tammy T. Huang, Joel H. Martin, Jeanette L. Fairhurst, Ashique Rafique, Marcela Torres, Kevin J. Pobursky, Raymond W. Leidich, Joan A. Windsor, Warren R. Mikulka, Dina M. Ahrens, Ergang Shi, Nicholas J. Papadopoulos
  • Modification assisted profiling (MAP) methodology
    Publication number: 20040101920
    Abstract: Methods of utilizing a biosensor platform for the purpose of studying macromolecule interactions is provided. Also provided are methods of sorting monoclonal antibodies directed against a particular antigen into functional groups wherein each group exhibits a characteristic binding profile to the antigen.
    Type: Application
    Filed: October 31, 2003
    Publication date: May 27, 2004
    Inventors: Czeslaw Radziejewski, Ergang Shi