Patents by Inventor Erhard Fernholz

Erhard Fernholz has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 8563263
    Abstract: The present invention is directed to a composition comprising a vanadium-containing phosphatase inhibitor and a polyol. In the presence of the polyol the effect of the inhibitor is enhanced, even in the presence of chelating agents or reducing agents. The invention also concerns the use of the inventive composition for inhibiting a phosphatase, as well as kits comprising the composition.
    Type: Grant
    Filed: August 29, 2012
    Date of Patent: October 22, 2013
    Assignee: Roche Diagnostics Operations Inc.
    Inventors: Erhard Fernholz, Dorothea Mayr
  • Publication number: 20120329134
    Abstract: The present invention is directed to a composition comprising a vanadium-containing phosphatase inhibitor and a polyol. In the presence of the polyol the effect of the inhibitor is enhanced, even in the presence of chelating agents or reducing agents. The invention also concerns the use of the inventive composition for inhibiting a phosphatase, as well as kits comprising the composition.
    Type: Application
    Filed: August 29, 2012
    Publication date: December 27, 2012
    Inventors: Erhard Fernholz, Dorothea Mayr
  • Patent number: 8278086
    Abstract: The present invention is directed to a composition comprising a vanadium-containing phosphatase inhibitor and a polyol. In the presence of the polyol the effect of the inhibitor is enhanced, even in the presence of chelating agents or reducing agents. The invention also concerns the use of the inventive composition for inhibiting a phosphatase, as well as kits comprising the composition.
    Type: Grant
    Filed: March 24, 2011
    Date of Patent: October 2, 2012
    Assignee: Roche Diagnostics Operations, Inc.
    Inventors: Erhard Fernholz, Dorothea Mayr
  • Patent number: 8008035
    Abstract: The present invention is directed to a composition comprising a vanadium-containing phosphatase inhibitor and a polyol. In the presence of the polyol the effect of the inhibitor is enhanced, even in the presence of chelating agents or reducing agents. The invention also concerns the use of the inventive composition for inhibiting a phosphatase, as well as kits comprising the composition.
    Type: Grant
    Filed: January 21, 2008
    Date of Patent: August 30, 2011
    Assignee: Roche Diagnostics Operations, Inc.
    Inventors: Erhard Fernholz, Dorothea Mayr
  • Publication number: 20110177577
    Abstract: The present invention is directed to a composition comprising a vanadium-containing phosphatase inhibitor and a polyol. In the presence of the polyol the effect of the inhibitor is enhanced, even in the presence of chelating agents or reducing agents. The invention also concerns the use of the inventive composition for inhibiting a phosphatase, as well as kits comprising the composition.
    Type: Application
    Filed: March 24, 2011
    Publication date: July 21, 2011
    Inventors: Erhard Fernholz, Dorothea Mayr
  • Publication number: 20080248550
    Abstract: The present invention is directed to a composition comprising a vanadium-containing phosphatase inhibitor and a polyol. In the presence of the polyol the effect of the inhibitor is enhanced, even in the presence of chelating agents or reducing agents. The invention also concerns the use of the inventive composition for inhibiting a phosphatase, as well as kits comprising the composition.
    Type: Application
    Filed: January 21, 2008
    Publication date: October 9, 2008
    Inventors: Erhard Fernholz, Dorothea Mayr
  • Publication number: 20040248238
    Abstract: The present invention concerns a method for producing a lysate containing helper proteins in which a strain which is suitable for obtaining in vitro translation lysates is transformed using a vector containing one or more genes coding for one or more helper proteins, wherein the helper proteins are expressed in this strain and the lysate containing helper proteins is obtained from these strains. The present invention also concerns a lysate containing helper proteins that can be obtained by the method according to the invention, blends of these lysates and the use of these lysates and blends in in vitro translation systems.
    Type: Application
    Filed: March 17, 2004
    Publication date: December 9, 2004
    Inventors: Manfred Watzele, Regina Schweizer, Cordula Nemetz, Robin Steigerwald, Thomas Emrich, Katrin Zaiss, Erhard Fernholz, Baerbel Walckhoff, Hans Joachim Schoenfeld, Birgit Offen
  • Patent number: 6235509
    Abstract: A process is provided for inhibiting serine proteases in a sample. The process involves adding to the sample a compound such as cresol or 3-hydroxypyridine and then adding to the sample a sulfonic acid derivative or a fluorophosphonate, to derivative the serine proteases. The compounds such as cresol or 3-hydroxypyridine avoid nonspecific derivatization of proteins other than the serine proteases.
    Type: Grant
    Filed: March 17, 1999
    Date of Patent: May 22, 2001
    Assignee: Roche Diagnostics GmbH
    Inventor: Erhard Fernholz
  • Patent number: 6218546
    Abstract: The invention concerns compounds which have a chromophore and a group capable of binding to streptavidin or/and avidin and which are suitable for binding to molecules containing an aldehyde, ketone, hemiacetal or/and hemiketal group. In addition the invention concerns conjugates formed from these compounds as well as a method for the detection or isolation of carbohydrates or glycan receptors by means of such conjugates.
    Type: Grant
    Filed: October 18, 1996
    Date of Patent: April 17, 2001
    Assignee: Roche Diagnostics GmbH
    Inventors: Manfred Watzele, Erhard Fernholz, Herbert Von Der Eltz
  • Patent number: 6060455
    Abstract: The invention concerns new cationic or polycationic amphiphiles which are capable of forming aggregates with macromolecules, in particular with DNA or RNA, and it concerns their delivery into prokaryotic or eukaryotic cells. Compounds with spermyl-dioleoyloxypropyl structure have proven to be particularly preferable.
    Type: Grant
    Filed: December 5, 1997
    Date of Patent: May 9, 2000
    Assignee: Boehringer Mannheim GmbH
    Inventors: Erhard Fernholz, Herbert Von Der Eltz, Matrhias Hinzpeter