Patents by Inventor Eri Hashino

Eri Hashino has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHODS OF GENERATING HUMAN INNER EAR SENSORY EPITHELIA AND SENSORY NEURONS
    Publication number: 20200370007
    Abstract: Provided herein are methods for directing differentiation of human pluripotent stem cells into inner ear sensory epithelia and sensory neurons. More particularly, provided herein are methods for obtaining three-dimensional cultures comprising human pluripotent stem cell-derived pre-otic epithelium, otic vesicles, and inner ear sensory epithelia containing hair cells, sensory neurons, and supporting cells.
    Type: Application
    Filed: August 10, 2020
    Publication date: November 26, 2020
    Inventors: Karl R. Koehler, Eri Hashino
  • Methods for generating the inner ear and other cranial placode-derived tissues using pluripotent stem cells
    Patent number: 10308911
    Abstract: Disclosed herein are methods and compositions for generating cultures and isolated cell populations containing preplacodal ectoderms cells, otic placode cells, and inner ear sensory hair cells derived from pluripotent cells by modulating TGF?, BMP, and FGF signaling pathways under defined culture conditions. Also described are methods for obtaining non-otic placodal tissues from pluripotent stem cells. Methods for identifying agents that induce or enhance differentiation and generation of hair cells are also disclosed. Methods for identifying cytoprotective agents for hair cells are also described.
    Type: Grant
    Filed: March 1, 2017
    Date of Patent: June 4, 2019
    Assignee: Indiana University Research & Technology Corporation
    Inventors: Eri Hashino, Gerry Oxford, Karl R. Koehler
  • METHODS OF GENERATING HUMAN INNER EAR SENSORY EPITHELIA AND SENSORY NEURONS
    Publication number: 20190093072
    Abstract: Provided herein are methods for directing differentiation of human pluripotent stem cells into inner ear sensory epithelia and sensory neurons. More particularly, provided herein are methods for obtaining three-dimensional cultures comprising human pluripotent stem cell-derived pre-otic epithelium, otic vesicles, and inner ear sensory epithelia containing hair cells, sensory neurons, and supporting cells.
    Type: Application
    Filed: October 21, 2016
    Publication date: March 28, 2019
    Applicant: Indiana University Research and Technology Corporation
    Inventors: Karl R. Koehler, Eri Hashino
  • METHODS FOR GENREATING THE INNER EAR AND OTHER CRANIAL PLACODE-DERIVED TISSUES USING PLURIPOTENT STEM CELLS
    Publication number: 20170240858
    Abstract: Disclosed herein are methods and compositions for generating cultures and isolated cell populations containing preplacodal ectoderms cells, otic placode cells, and inner ear sensory hair cells derived from pluripotent cells by modulating TGF?, BMP, and FGF signaling pathways under defined culture conditions. Also described are methods for obtaining non-otic placodal tissues from pluripotent stem cells. Methods for identifying agents that induce or enhance differentiation and generation of hair cells are also disclosed. Methods for identifying cytoprotective agents for hair cells are also described.
    Type: Application
    Filed: March 1, 2017
    Publication date: August 24, 2017
    Inventors: Eri Hashino, Gerry Oxford, Karl R. Koehler
  • Methods for generating the inner ear and other cranial placode-derived tissues using pluripotent stem cells
    Patent number: 9624468
    Abstract: Disclosed herein are methods and compositions for generating cultures and isolated cell populations containing preplacodal ectoderms cells, otic placode cells, and inner ear sensory hair cells derived from pluripotent cells by modulating TGF?, BMP, and FGF signaling pathways under defined culture conditions. Also described are methods for obtaining non-otic placodal tissues from pluripotent stem cells. Methods for identifying agents that induce or enhance differentiation and generation of hair cells are also disclosed. Methods for identifying cytoprotective agents for hair cells are also described.
    Type: Grant
    Filed: May 6, 2013
    Date of Patent: April 18, 2017
    Assignee: Indiana University Research & Technology Corporation
    Inventors: Eri Hashino, Gerry Oxford, Karl R. Koehler
  • METHODS FOR GENERATING THE INNER EAR AND OTHER CRANIAL PLACODE-DERIVED TISSUES USING PLURIPOTENT STEM CELLS
    Publication number: 20150125953
    Abstract: Disclosed herein are methods and compositions for generating cultures and isolated cell populations containing preplacodal ectoderms cells, otic placode cells, and inner ear sensory hair cells derived from pluripotent cells by modulating TGF?, BMP, and FGF signaling pathways under defined culture conditions. Also described are methods for obtaining non-otic placodal tissues from pluripotent stem cells. Methods for identifying agents that induce or enhance differentiation and generation of hair cells are also disclosed. Methods for identifying cytoprotective agents for hair cells are also described.
    Type: Application
    Filed: May 6, 2013
    Publication date: May 7, 2015
    Inventors: Eri Hashino, Gerry Oxford, Karl R. Koehler