Abstract: A pharmaceutical formulation to be administered by a medicament administration device, which can maintain high stability of a biological active substance, is provided. In preparing the pharmaceutical formulation to be administered via mucous membrane, particularly a pharmaceutical formulation to be inhaled by utilizing a jet nebulizer, an ultrasonic nebulizer, a metered dose inhaler, or a dry powder inhaler, the adoption of the step of contacting the biological active substance with liposomes or microspheres in an aqueous medium enables the substance to be highly stabilized.

Abstract: A process for producing microcapsules with an adhesive coating layer which comprises forming a slurry of microcapsules in a medium selected from water, one or more organic solvents or a mixture thereof by a coacervation method, adding powders of a pharmaceutically acceptable inorganic compound which is insoluble in the medium to the slurry, so that the inorganic compound adheres to substantially the overall surface of the adhesive coating layer, and separating the microcapsules from the medium.