Abstract: When a pathway is generated based on property information representing a property of a molecule acting on a disease or symptom, interactome information representing a connection relationship between molecules, and similarity information representing a similarity between molecules, the pathway is generated using a minimum flow algorithm to satisfy at least two conditions that (1) a path is generated by connecting only molecules whose flow values are greater than a minimum threshold and less than a maximum threshold, and (2) a path is generated by connecting only molecules whose flow values are equal to or less than a threshold related to a similarity. In this way, when a specific molecule is knocked out in a pathway once generated and the pathway is regenerated, changes occur not only in a path in which the knocked-out molecule is present but also in other paths, and an appropriate pathway reflecting the knocked-out state can be generated.

Abstract: Methods are disclosed herein for determining whether a subject has a Tauopathy, such as Pick disease, Alzheimer disease, progressive supranuclear palsy (PSP), corticobasal degeneration (CBD) or argyrophilic grain disease (AGD). These methods utilize an amyloid seeding assay.

Abstract: Methods are disclosed herein for determining whether a subject has a Tauopathy, such as Pick disease, Alzheimer disease, progressive supranuclear palsy (PSP), corticobasal degeneration (CBD) or argyrophilic grain disease (AGD). These methods utilize an amyloid seeding assay.

Abstract: An engaging groove (47) with which a gasket (42) is engaged is provided in each of a front side projecting portion (44) and a rear side projecting portion (46) formed in a filter accommodating cylinder (37) to be positioned on an outer peripheral surface (44A, 46A) of each projecting portion (44, 46). Therefore, when the gasket (42) latches on each of the projecting portion (44; 46) to be fitted thereon from an outside, the gasket (42) can be engaged with the engaging groove (47) provided in each of the projecting portions (44, 46). In consequence, at the time of mounting and removing the filter accommodating cylinder (37), the falling-off of the gasket (42) can be prevented, and, for example, an inspection operation, a cleaning operation and the like of an accommodated particulate matter removing filter (41) can be easily performed.

Abstract: An engaging groove (47) with which a gasket (42) is engaged is provided in each of a front side projecting portion (44) and a rear side projecting portion (46) formed in a filter accommodating cylinder (37) to be positioned on an outer peripheral surface (44A, 46A) of each projecting portion (44, 46). Therefore, when the gasket (42) latches on each of the projecting portion (44; 46) to be fitted thereon from an outside, the gasket (42) can be engaged with the engaging groove (47) provided in each of the projecting portions (44, 46). In consequence, at the time of mounting and removing the filter accommodating cylinder (37), the falling-off of the gasket (42) can be prevented, and, for example, an inspection operation, a cleaning operation and the like of an accommodated particulate matter removing filter (41) can be easily performed.