Patents by Inventor Eri Tabuchi

Eri Tabuchi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Mutant glutamate-cysteine ligase and method for manufacturing gamma glutamyl-valyl-glycine
    Patent number: 10113161
    Abstract: A mutant glutamate-cysteine ligase (GSHA) suitable for generating ?-Glu-Val, and a method for producing ?-Glu-Val-Gly using the same are provided. ?-Glu-Val is produced by using a mutant GSHA having a specific mutation with Glu and Val as raw materials, and ?-Glu-Val-Gly is further produced by using ?-Glu-Val and Gly as raw materials. ?-Glu-Val-Gly is produced by using a mutant GSHA having a specific mutation with Glu, Val, and Gly as raw materials.
    Type: Grant
    Filed: July 29, 2016
    Date of Patent: October 30, 2018
    Assignee: AJINOMOTO CO., INC.
    Inventors: Ayako Sasahara, Eri Tabuchi, Hideyuki Suzuki, Uno Tagami, Tatsuki Kashiwagi, Takayuki Ito, Hiroyuki Nozaki, Shunichi Suzuki
  • MUTANT GLUTAMATE-CYSTEINE LIGASE AND METHOD FOR MANUFACTURING GAMMA-GLUTAMYL-VALYL-GLYCINE
    Publication number: 20160326510
    Abstract: A mutant glutamate-cysteine ligase (GSHA) suitable for generating ?-Glu-Val, and a method for producing ?-Glu-Val-Gly using the same are provided. ?-Glu-Val is produced by using a mutant GSHA having a specific mutation with Glu and Val as raw materials, and ?-Glu-Val-Gly is further produced by using ?-Glu-Val and Gly as raw materials. ?-Glu-Val-Gly is produced by using a mutant GSHA having a specific mutation with Glu, Val, and Gly as raw materials.
    Type: Application
    Filed: July 29, 2016
    Publication date: November 10, 2016
    Applicant: AJINOMOTO CO., INC.
    Inventors: Ayako SASAHARA, Eri Tabuchi, Hideyuki Suzuki, Uno Tagami, Tatsuki Kashiwagi, Takayuki Ito, Hiroyuki Nozaki, Shunichi Suzuki
  • METHOD FOR PRODUCING MONATIN USING AN L-AMINO ACID AMINOTRANSFERASE
    Publication number: 20140234916
    Abstract: The present invention provides a methodology for improving a yield of 2R,4R-Monatin. Specifically, the present invention provides a method for producing 2S,4R-Monatin or a salt thereof, comprising contacting 4R-IHOG with an L-amino acid aminotransferase in the presence of an L-amino acid to form the 2S,4R-Monatin; a method for producing 2R,4R-Monatin or a salt thereof, comprising isomerizing the 2S,4R-Monatin to form the 2R,4R-Monatin; and the like. These production methods may further comprise condensing indole-3-pyruvate and pyruvate to form the 4R-IHOG, and deaminating a tryptophan to form the indole-3-pyruvate.
    Type: Application
    Filed: March 31, 2014
    Publication date: August 21, 2014
    Applicant: Ajinomoto Co., Inc.
    Inventors: Yasuaki Takakura, Hiroomi Ogino, Masakazu Sugiyama, Kenichi Mori, Eri Tabuchi, Koki Ishikawa, Uno Tagami, Hidemi Fujii
  • Method for producing monatin using an L-amino acid aminotransferase
    Patent number: 8771997
    Abstract: The present invention provides a methodology for improving a yield of 2R,4R-Monatin. Specifically, the present invention provides a method for producing 2S,4R-Monatin or a salt thereof, comprising contacting 4R-IHOG with an L-amino acid aminotransferase in the presence of an L-amino acid to form the 2S,4R-Monatin; a method for producing 2R,4R-Monatin or a salt thereof, comprising isomerizing the 2S,4R-Monatin to form the 2R,4R-Monatin; and the like. These production methods may further comprise condensing indole-3-pyruvate and pyruvate to form the 4R-IHOG, and deaminating a tryptophan to form the indole-3-pyruvate.
    Type: Grant
    Filed: October 12, 2011
    Date of Patent: July 8, 2014
    Assignee: Ajinomoto Co., Inc.
    Inventors: Yasuaki Takakura, Hiroomi Ogino, Masakazu Sugiyama, Kenichi Mori, Eri Tabuchi, Koki Ishikawa, Uno Tagami, Hidemi Fujii
  • METHOD FOR PRODUCING MONATIN
    Publication number: 20120295314
    Abstract: The present invention provides a method of producing 2R,4R-Monatin with a good yield using inexpensive L-Trp rather than expensive D-Trp as a stating material. Specifically, the present invention provides a method for producing 2R,4R-Monatin or a salt thereof, comprising: (1) contacting L-tryptophan with a deamination enzyme to form indole-3-pyruvate; (2) contacting the indole-3-pyruvate and pyruvate with an aldolase to form 4R-IHOG; and (3) contacting the 4R-IHOG with a D-aminotransferase in the presence of a D-amino acid to form the 2R,4R-Monatin; and the like. In (3), it is preferable to use a D-aminotransferase having no or low ability to form D-tryptophan from indole-3-pyruvate.
    Type: Application
    Filed: April 25, 2012
    Publication date: November 22, 2012
    Applicant: Ajinomoto Co., Inc.
    Inventors: Masakazu Sugiyama, Yasuaki Takakura, Mika Moriya, Yusuke Hagiwara, Eri Tabuchi
  • METHOD FOR PRODUCING MONATIN
    Publication number: 20120270279
    Abstract: The present invention provides a methodology for improving a yield of 2R,4R-Monatin. Specifically, the present invention provides a method for producing 2S,4R-Monatin or a salt thereof, comprising contacting 4R-IHOG with an L-amino acid aminotransferase in the presence of an L-amino acid to form the 2S,4R-Monatin; a method for producing 2R,4R-Monatin or a salt thereof, comprising isomerizing the 2S,4R-Monatin to form the 2R,4R-Monatin; and the like. These production methods may further comprise condensing indole-3-pyruvate and pyruvate to form the 4R-IHOG, and deaminating a tryptophan to form the indole-3-pyruvate.
    Type: Application
    Filed: October 12, 2011
    Publication date: October 25, 2012
    Applicant: AJINOMOTO CO. INC
    Inventors: Yasuaki Takakura, Hiroomi Ogino, Masakazu Sugiyama, Kenichi Mori, Eri Tabuchi, Koki Ishikawa, Uno Tagami, Hidemi Fujii