Patents by Inventor Eric A. Althoff

Eric A. Althoff has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Bacterial small-molecule three-hybrid system
    Patent number: 7083918
    Abstract: A transgenic bacterial cell comprising (a) a dimeric small molecule which comprises a first moiety known to bind a first receptor domain covalently linked to a second moiety known to bind a second receptor domain; (b) nucleotide sequences which upon transcription encode i) a first fusion protein comprising the first receptor domain, and ii) a second fusion protein comprising the second receptor domain; and (c) a reporter gene wherein expression of the reporter gene is conditioned on the proximity of the first fusion protein to the second fusion protein. The cell is also adapted for use in a method for identifying a molecule that binds to a known target in a bacterial cell from a pool of candidate molecules, and a method for identifying an unknown target receptor to which a molecule is capable of binding in a bacterial cell. Also described are compounds and kits for carrying out the methods.
    Type: Grant
    Filed: April 24, 2002
    Date of Patent: August 1, 2006
    Assignee: The Trustees of Columbia University in the City of New York
    Inventors: Eric A. Althoff, Virginia W. Cornish
  • Bacterial small-molecule three-hybrid system
    Publication number: 20030203471
    Abstract: A transgenic bacterial cell comprising
    Type: Application
    Filed: April 24, 2002
    Publication date: October 30, 2003
    Inventors: Eric A. Althoff, Virginia W. Cornish