Abstract: Antibacterial compounds of formula I are provided: As well as stereoisomers, pharmaceutically acceptable salts, esters, and prodrugs thereof; pharmaceutical compositions comprising such compounds; methods of treating bacterial infections by the administration of such compounds; and processes for the preparation of the compounds.

Abstract: Methods of inhibiting fibroblast growth factor receptor 3 and treating various conditions mediated by fibroblast growth factor receptor 3 are provided that include administering to a subject a compound of Structure I, a pharmaceutically acceptable salt thereof, a tautomer thereof, or a pharmaceutically acceptable salt of the tautomer. Compounds having the Structure I have the following structure where and have the variables described herein. Such compounds may be used to prepare medicaments for use in inhibiting fibroblast growth factor receptor 3 and for use in treating conditions mediated by fibroblast growth factor receptor 3 such as multiple myeloma.

Abstract: A lacate salt of a compound of Formula I or a tautomer of the compound, wherein Formula I has the following structure and R1-R9 and R12-R14 are as defined herein

Abstract: A method is provided for designing deformations that will achieve an optimum reduction in vibration related noise in an exhaust system component. The method entails defining an initial shape for an exhaust system component based on available space and exhaust flow characteristics. The shape is converted to a mesh having a plurality of interconnected grids. The mesh then is deformed to define an optimal theoretical configuration for the exhaust system component that will eliminate at least selected natural frequencies. The resulting shape then is converted to a plurality of small flat surfaces that intersect, and a point cloud is created from the array of small flat intersecting surfaces of the optimal theoretical exhaust system component. The point cloud is employed to smooth out intersecting surfaces and to achieve an optimal manufacturable configuration for the exhaust system component.

Abstract: A method of synthesizing a substituted or unsubstituted 4-amino-3-benzimidazolyl quinolinone compound includes reacting a first compound having the formula I with a second compound having the formula II in a suitable solvent in the presence of a sodium or potassium salt of a base.

Abstract: Antibacterial compounds of formula I are provided: 1

Abstract: Methods of treating cancer using 4-amino-5-fluoro-3-[6-(4-methylpiperazin-1 -yl)-1H-benzimidazol-2-yl]quinolin-2(1H)-one are provided. In particular, the methods are effective for the treatment of solid tumors or leukemias, including prostate, colorectal, breast, multiple myeloma, pancreatic, small cell carcinoma, acute myelogenous leukemia, chronic myelogenous leukemia, or myelo-proliferative disease. Further provided are methods of measuring the amount of 4-amino-5-fluoro-3-[6-(4-methylpiperazin-1 -yl)-1H-benzimidazol-2-yl]quinolin-2(1H)-one and determining a metabolic profile therefore.

Abstract: A method is provided for designing deformations that will achieve an optimum reduction in vibration related noise in an exhaust system component. The method comprises defining an initial shape for an exhaust system component based on available space and exhaust flow characteristics. The shape is converted to a mesh having a plurality of interconnected grids. The mesh then is deformed to define an optimal theoretical configuration for the exhaust system component that will eliminate at least selected natural frequencies. The resulting shape then is converted to a plurality of small flat surfaces that intersect, and a point cloud is created from the array of small flat intersecting surfaces of the optimal theoretical exhaust system component. The point cloud is employed to smooth out intersecting surfaces and to achieve an optimal manufacturable configuration for the exhaust system component.