Abstract: Methods for rotationally aligning transcatheter heart valve prosthesis within a native heart valve include percutaneously delivering the transcatheter heart valve prosthesis to the native heart valve, wherein the transcatheter heart valve prosthesis includes at least one imaging marker, receiving a cusp overlap viewing angle image and/or a coronary overlap viewing angle image of the transcatheter heart valve prosthesis within the native heart valve, determining, based on the cusp overlap viewing angle image and/or the coronary overlap viewing angle image and the at least one imaging marker, whether the transcatheter heart valve prosthesis is in a desired rotational orientation, if the at least one imaging marker in the cusp overlap viewing angle image and/or the coronary overlap viewing angle indicates that the transcatheter heart valve prosthesis is not in the desired rotational orientation, rotating the transcatheter heart valve prosthesis until the transcatheter heart valve prosthesis is in the desired rot

Abstract: A kitchen appliance includes a casing including a base and a column extending from the base along the vertical direction, the casing defining an interior surface directed toward an interior cavity and an exterior surface directed away from the interior cavity, a pair of tabs protruding from the interior surface of the casing along the vertical direction toward the interior cavity of the casing, the pair of tabs being spaced apart from each other along the lateral direction to define a horizontal channel for receiving a load cell therein, and a pin protruding from the interior surface of the casing along the vertical direction toward the interior cavity of the casing, the pin being spaced apart from the pair of tabs along the transverse direction and disposed along the horizontal channel.

Abstract: An aqueous treating medium may include water; an acid selected from the group consisting of: HCl, HBr, HNO3, H2SO4, H2SO3, H3PO4, H3PO2, HOAc, citric acid, tartaric acid, ascorbic acid, EDTA, methanesulfonic acid, toluenesulfonic acid, and combinations thereof, wherein a concentration of the acid in the aqueous treating medium is from 0.5 M to 1.5 M; a salt, wherein a concentration of the salt in the aqueous treating medium is from greater than 0 M to 2 M; a fluoride-containing compound selected from the group consisting of: HF, NaF, NH4HF2, and combinations thereof, wherein a concentration of the fluoride-containing compound in the aqueous treating medium is from 0.026 M to 0.26 M; and silica, wherein the aqueous treating medium is saturated with silica.

Abstract: An example medical system includes a medical device configured to join the edges of the leaflets together, an elongate body configured to be navigated through vasculature to a heart valve of patient, and a plurality of tissue engagement devices extending from a distal end of the elongate body, each tissue engagement device comprising at least one clamp configured to capture leaflets of the heart valve.

Abstract: The disclosure provides methods of deaminating adenosine and cytosine bases in a target nucleic acid sequence in an USH2A gene comprising contacting the USH2A gene with a base editor in association with a guide RNA (gRNA). In some aspects, base editing is used to restore US2HA function by disrupting a splice site in the USH2A gene sequence to induce skipping of an exon containing a mutation, while in other embodiments, base editing is used to restore US2HA function by correcting a point mutation e.g., in an exon) so as to correct mutations. The disclosure also provides complexes of adenosine base editors and guide RNAs, and complexes of cytidine base editors and guide RNAs. The disclosure further provides pharmaceutical compositions and cells comprising these complexes. The disclosure also provides vectors encoding these complexes, base editors, and gRNAs. In some embodiments, the methods and compositions provided herein are used to treat Usher syndrome and autosomal recessive retinitis pigmentosa (arRP).

Abstract: An example medical system includes a medical device configured to join the edges of the leaflets together, an elongate body configured to be navigated through vasculature to a heart valve of patient, and a plurality of tissue engagement devices extending from a distal end of the elongate body, each tissue engagement device comprising at least one clamp configured to capture leaflets of the heart valve.

Abstract: A skirt-reinforcement member for supporting or reinforcing an unsupported portion of a skirt that spans across a side opening of a stent or frame of a valve prosthesis. The skirt-reinforcement member is configured to prevent billowing of the skirt material that spans across the side opening of the inner frame of the valve prosthesis, as such billowing may undesirably result in contact between the skirt and leaflets of the valve prosthesis after the valve prosthesis is deployed in situ.

Abstract: A prosthesis includes a frame and a skirt coupled to a surface of the frame. The skirt extends over at least one side opening of a plurality of side openings of the frame. The prosthesis also includes a skirt-reinforcement member that spans the at least one side opening from a first crown or strut edge defining the at least one side opening to a second crown or strut edge defining the at least one side opening. The skirt-reinforcement member has a first end, a second end, and a length therebetween. The first end of the skirt-reinforcement member is attached to the first crown or strut edge and the second end of the skirt-reinforcement member is attached to the second crown or strut edge. The skirt-reinforcement member is attached to the skirt along an unsupported portion of the skirt that spans the at least one side opening.

Abstract: Methods for rotationally aligning transcatheter heart valve prosthesis within a native heart valve include percutaneously delivering the transcatheter heart valve prosthesis to the native heart valve, wherein the transcatheter heart valve prosthesis includes at least one imaging marker, receiving a cusp overlap viewing angle image and/or a coronary overlap viewing angle image of the transcatheter heart valve prosthesis within the native heart valve, determining, based on the cusp overlap viewing angle image and/or the coronary overlap viewing angle image and the at least one imaging marker, whether the transcatheter heart valve prosthesis is in a desired rotational orientation, if the at least one imaging marker in the cusp overlap viewing angle image and/or the coronary overlap viewing angle indicates that the transcatheter heart valve prosthesis is not in the desired rotational orientation, rotating the transcatheter heart valve prosthesis until the transcatheter heart valve prosthesis is in the desired rot

Abstract: Methods and compositions for gene therapy of retinal degeneration related to mutations in nicotinamide mononucleotide adenylyltransferase 1 (NMNAT1).

Abstract: Compositions for use in treating subjects with USH2A-associated retinal and/or cochlear degeneration that result from mutations in exon 13 of the USH2A gene by deletion of exon 13 from the USH2A gene or transcripts, and methods of use thereof, as well as genetically modified animals and cells.

Abstract: The present invention relates to methods and compositions for gene therapy of retinitis pigmentosa related to mutations in pre-mRNA processing factor 31 (PRPF31).

Abstract: An example medical system includes a medical device configured to join the edges of the leaflets together, an elongate body configured to be navigated through vasculature to a heart valve of patient, and a plurality of tissue engagement devices extending from a distal end of the elongate body, each tissue engagement device comprising at least one clamp configured to capture leaflets of the heart valve.

Abstract: Methods of detecting a mutation associated with a genetic eye disease in a subject, using target enrichment and next generation sequencing.

Abstract: The present invention relates to methods and compositions for gene therapy of retinitis pigmentosa related to mutations in pre-mRNA processing factor 31 (PRPF31).

Abstract: Data comprising a request specifying a desired change in electrical load for a defined period of time is received. The electrical load is associated with a plurality of resources under control of resource agents and on a utility grid. Available capacity of resources within the control of each resource agent over the defined period of time is determined. Each available capacity is determined at least using a resource load model. Using the determined available capacity of resources over the defined period of time, resource scheduling instructions are calculated for a subset of resources. The resource scheduling instructions satisfy the desired change in electrical load of the request. Data characterizing the resource scheduling instructions is provided. Related systems, apparatus, methods, and articles are also described.

Abstract: The subject matter described herein relates to the organized measurement, dispatch and/or control of disparate and distributed resources along the length of and at the ends of the electrical grid. Related systems, apparatus, methods, and articles are also described.

Abstract: Systems are described that provide monitoring for control, measurement and verification of demand side management resources. Control units deployed among customer or utility premises can monitor capacity as real or reactive power that is consumed, generated or stored by resources and, in some cases, selectively alter the load consumed or energy delivered by some or all of such resources derived from load capacity and dispatch models. Related apparatus, systems, techniques and articles are also described.

Abstract: Systems are described that provide monitoring for control, measurement and verification of demand side management resources. Control units deployed among customer or utility premises can monitor capacity as real or reactive power that is consumed, generated or stored by resources and, in some cases, selectively alter the load consumed or energy delivered by some or all of such resources derived from load capacity and dispatch models. Related apparatus, systems, techniques and articles are also described.

Abstract: A web server receives from different client applications HTTP requests for the same webpage in which video content is to be embedded. The web server provides to each of the client applications an HTTP response to the HTTP request. The HTML or XHTML text included in the response references the video content solely in a manner that is specific to a single video player. The HTML or XHTML text returned in a response to a request may be different for different client applications, even though the different client applications all requested the same webpage or portion of webpage. The video file referenced by the HTML or XHTML text returned in a response may be different for different client applications, even though the video files encode the same video content.