Abstract: Disclosed herein are methods and compositions for normalizing polynucleotide concentration. Normalizing may be accomplished using polynucleotide binding proteins (e.g., catalytically inactive CRISPR protein or catalytically inactive Argonaute proteins). The polynucleotide binding proteins may bind to the adapter sequences of a target polynucleotide. Thus, adding the same amount of a polynucleotide binding proteins to different samples and then extracting the polynucleotide protein is shown herein to extract similar amounts of target polynucleotides from the different samples.

Abstract: Systems and methods for adjusting a display in a vehicle are provided. The display is configured to present information in one or more regions of the display. The position of a user in the vehicle is detected and based on detecting a change in position of the user, the position of information on the display may be adjusted. For example, when the change in position of the user causes information on the display to be obstructed, the position of the information may be adjusted to an unobstructed region of the display.

Abstract: An insertion tool guide for a medical procedure like a biopsy. The tool guide includes (a) a frame configured to be adjoined to a medical image modality and maintain an insertion angle aligned with a plane of view generated by the medical image modality; (b) a guide body having an adjustable channel configured to receive and translate an insertion tool; (c) a main channel defined by the frame configured to allow the guide body and the insertion tool to rotate within a plane of movement; (d) a guide channel formed along one side of the frame configured to allow the guide body to translate along its length; and (e) a peg extending from the guide body and through the guide channel to secure the guide body within the frame. The guide body is configured to rotate about an axis defined by the peg.

Abstract: Various embodiments set forth a computer-implemented method for selectively caching digital content for streaming, comprising analyzing a set of traffic data associated with streaming of a plurality of media items in a first time period, selecting, based on the set of traffic data, a first media item for storage in a cache during a second time period, and storing in the cache, prior to receiving a request for the first media item in the second time period, at least a portion of a first media stream of a plurality of media streams associated with the first media item, and at least a portion of a second media stream of the plurality of media streams, wherein each media stream in the plurality of media streams is encoded with different characteristics.

Abstract: A method and system operable for receiving a search query from a user; receiving contextual information; based on the contextual information, suggesting one or more of a search query refinement and a search query addition; receiving a selection of the one or more of the search query refinement and the search query addition from the user; based on the selection, forming a refined search query; and performing a search of a database based on the refined search query and returning corresponding results to the user.

Abstract: Various embodiments set forth a computer-implemented method for selectively caching digital content for streaming, comprising analyzing a set of traffic data associated with streaming of a plurality of media items in a first time period, selecting, based on the set of traffic data, a first media item for storage in a cache during a second time period, and storing in the cache, prior to receiving a request for the first media item in the second time period, at least a portion of a first media stream of a plurality of media streams associated with the first media item, and at least a portion of a second media stream of the plurality of media streams, wherein each media stream in the plurality of media streams is encoded with different characteristics.

Abstract: Representative embodiments disclose intelligent help systems that monitor user interactions through email, digital assistants, and other applications and recognize when a user can utilize the help of an expert with a task. The system detects user intent and a category of problem from the interactions (i.e., email communications, etc.) and searches a database of user profiles to find experts with the proper expertise to help the user with the category of problem. User intent can be detected by parsing communications, extracting features from the communications, and using the extracted features to identify intent, such as through matching or machine learning. A social score and an expertise score are calculated for expert profiles from the database. The social score is based on a degree of separation and expert and the expertise score is based on a level of expertise. Experts and areas of commonality are presented to the user.

Abstract: Systems and methods for detecting and controlling bed height in fluidized bed reactors are disclosed. The systems and methods employ a plurality of radiation sources and a detector array located along the outer surface of a fluidized bed reactor.

Abstract: Systems and methods for detecting and controlling bed height in fluidized bed reactors are disclosed. The systems and methods employ a plurality of radiation sources and a detector array located along the outer surface of a fluidized bed reactor.

Abstract: Representative embodiments disclose intelligent help systems that monitor user interactions through email, digital assistants, and other applications and recognize when a user can utilize the help of an expert with a task. The system detects user intent and a category of problem from the interactions (i.e., email communications, etc.) and searches a database of user profiles to find experts with the proper expertise to help the user with the category of problem. User intent can be detected by parsing communications, extracting features from the communications, and using the extracted features to identify intent, such as through matching or machine learning. A social score and an expertise score are calculated for expert profiles from the database. The social score is based on a degree of separation and expert and the expertise score is based on a level of expertise. Experts and areas of commonality are presented to the user.

Abstract: Surgical tools that increase surgical accuracy for orthopedic procedures involving long bone osteotomy with or without supplementation with allograft or autograft. Two clamps on the operative side are rigidly interconnected to one another with an adjustable rod that is locked into place, preserving length and rotation of the bone. A graft preparation device is used on the operative table. It enables alignment of the graft to preserve the desired mechanical and anatomic axes and to provide rigid fixation of the graft for cutting. Adjustable jigs ensure exact cuts.

Abstract: A computer-implemented method is disclosed to assist a user to view image product designs at a graphic user interface. The method includes displaying an image representation in a page view at a graphic user interface, allowing a user to select the image representation in the page view, displaying a navigation panel in association with the image representation in the same page view, allowing the user to make a first selection in the navigation panel in the page view, displaying a first product design in the same page view according to the first selection, allowing the user to make a second selection in the navigation panel in the page view, displaying a second product design in the same page view according to the second selection, and removing the display of the navigation panel in the same page view when the product designs are deselected by the user.

Abstract: The invention discloses a surgical technique and apparatus for minimally invasive replacement of a fractured femoral head in hip arthroscopy. The fractured femoral head is first removed from the patient, and an incision made on the patient on a lateral aspect of the operative thigh. A hole is then drilled into the cortex of the operative femur of the patient through the incision. The femoral neck and femoral canal of the operative femur are reamed by inserting a reamer through the drilled hole. A hip prosthesis is then inserted into the wound and injected with molding. The hip prosthesis includes a femoral component having a distal end and a proximal end, the distal end inserted and anchored in the reamed femoral canal, and a femoral head component with smooth surface. The femoral head component contains a deflated balloon that, when inflated with molding, is similar to a neo-femoral head.

Abstract: Systems and methods for determining whether a muscle-invasive bladder cancer patient may respond to neoadjuvant chemotherapy based on identifying alterations in the ATM, Rb, FANCC, MTOR, PIK3C3, MYCN, CDKN2B, MLL2, NOTCH3, APC, NF1, and/or KDR genes in the patient are provided. If a patient has such alterations, the patient may be administered neoadjuvant chemotherapy prior to surgical bladder removal or bladder preservation therapy. If a patient does not have such alterations, the patient is not administered neoadjuvant chemotherapy prior to surgical bladder removal or bladder preservation therapy.

Abstract: A computer-implemented method is disclosed to assist a user to view image product designs at a graphic user interface. The method includes displaying an image representation in a page view at a graphic user interface, allowing a user to select the image representation in the page view, displaying a navigation panel in association with the image representation in the same page view, allowing the user to make a first selection in the navigation panel in the page view, displaying a first product design in the same page view according to the first selection, allowing the user to make a second selection in the navigation panel in the page view, displaying a second product design in the same page view according to the second selection, and removing the display of the navigation panel in the same page view when the product designs are deselected by the user.

Abstract: A computer-implemented method is disclosed for a user to view image product at a graphic user interface. The method includes displaying an image representation of a multi-page product in a page view at a graphic user interface, allowing a user to select the image representation in the page view, enabling display by a computer system, in the same page view, of a navigation panel in association with the image representation, wherein the navigation panel provides a plurality of selections each associated with one or more pages in the multi-page product, allowing the user to make a first selection in the navigation panel in the page view, displaying first one or more pages of the multi-page product in the same page view according to the first selection, and removing the display of the navigation panel in the same page view when the multi-page product is deselected by the user.

Abstract: The invention discloses a surgical technique and apparatus for minimally invasive replacement of a fractured femoral head in hip arthroscopy. The fractured femoral head is first removed from the patient, and an incision made on the patient on a lateral aspect of the operative thigh. A hole is then drilled into the cortex of the operative femur of the patient through the incision. The femoral neck and femoral canal of the operative femur are reamed by inserting a reamer through the drilled hole. A hip prosthesis is then inserted into the wound and injected with molding. The hip prosthesis includes a femoral component having a distal end and a proximal end, the distal end inserted and anchored in the reamed femoral canal, and a femoral head component with smooth surface. The femoral head component contains a deflated balloon that, when inflated with molding, is similar to a neo-femoral head.

Abstract: A surgical needle including a jam cleat for preventing slippage of suture. The jam cleat includes a suture engaging V-shaped tapered groove having opposing side walls that meet at a jam point.

Abstract: The present invention relates to lipoparticles. The invention also relates to producing lipoparticles. The invention further relates to lipoparticles comprising a viral structural protein. The invention further relates to a lipoparticle comprising a membrane protein, and the lipoparticle can be attached to a sensor surface. The invention further relates to methods of producing and using the lipoparticle to, inter alia, assess protein binding interactions.

Abstract: An apparatus is provided for the laparoscopic deployment and positioning of surgical materials, such as mesh. The mesh is applied by at least one extension arm which radiates from a central shaft. Alternate embodiments employ simultaneously and/or individually extended rigid arms, and simultaneously deployed resilient arms. Various methods are also disclosed for attaching the mesh to the abdominal wall once it is deployed by the extension arms. Illustrative attaching methods include staples, low viscosity adhesives, and electro-cauterization.