Abstract: A chemical mechanical polishing pad includes a surface portion of a first material. The surface portion includes a plurality of grooves. A first portion of the grooves are exposed grooves located at a surface of the chemical mechanical polishing pad. A second portion of the grooves are buried grooves embedded below the surface of the chemical mechanical polishing pad, such that, during use of the chemical mechanical polishing pad, one or more of the buried grooves are exposed at the surface.

Abstract: A method for characterizing a mobile particle in a sample includes acquisition of at least one image of the sample during an acquisition period, using an image sensor and formation of a series of images, the series of images comprising at least one image; use of each image of the series of images as input image of a detection convolutional neural network, the detection convolutional neural network being configured to detect the particles and to produce, from each image, an output image on which each detected particle is assigned a distribution of intensity, centered on the particle and extending around the particle; for each detected particle, from each output image, estimation of a position of each detected particle in each image of the series of images; and characterization of each detected particle from the estimation of the position established from each image of the series of images.

Abstract: The support comprises an object-carrying slide (11) and a cover glass (12) secured by lines of adhesive (13) peripherally defining individual compartments (14) for receiving a sample of the biological substance; characterised in that the upper face (17) of the object-carrying slide is bare and uncovered over at least one front marginal region (41) and at least one rear marginal region (42), each having an extension in the front-rear direction equal to at least 2.5 mm and an extension in the left-right direction equal to at least the distance between the respective axes of the two individual compartments furthest apart from one another. The system comprises the support (40) and a microscope for enclosing the support between a stage and a support plate provided with fingers, the distal ends of which are in contact with the marginal regions (41, 42) exclusively.

Abstract: The present disclosure relates to a method for monitoring a first processor using a second processor in a field device, comprising the following method steps: calculating verification data on the basis of specified input data using a test algorithm on an external computing unit storing the input data and the verification data computed by the test algorithm; transferring the specified input data stored in the sensor module and the verification data; transferring the specified input data; executing the test algorithm on the first processor; making the calculated output data available on the second processor; checking the output data with the verification data using the second processor and, if the output data do not correspond to the verification data, establishing a malfunction.

Abstract: The invention relates to a method for increasing the lifespan of animal sperm comprising contacting said sperm with an inhibitor of Slo3 potassium channel. The invention also relates to a use of an inhibitor of Slo3 potassium channel, for increasing the lifespan of animal sperm or motility of capacitated animal sperm, comprising contacting an inhibitor of Slo3 potassium channel with said sperm. Moreover, the invention relates to an artificial insemination instrument for use in artificial insemination of an animal, comprising animal sperm in contact with an inhibitor of Slo3 potassium channel. The invention also relates to a method for artificially inseminating an animal using said artificial insemination instrument. Eventually, the invention relates to a method for increasing the fertility of an animal, comprising contacting sperm of said animal with an inhibitor of Slo3 potassium channel; then artificially inseminating said animal with said sperm.

Abstract: The invention relates to a device for cryogenic freezing of units for packaging a biological substance comprising a receptacle (2) configured such that a stream of vapour of a cryogenic agent circulates therein, having at its top an insertion opening (10) for inserting the packaging units into the receptacle (2), a lid (3) that is able to move between a closed position in which it closes the insertion opening (10) and an open position in which it leaves the insertion opening (10) open, and a port (4) for discharging the vapour, provided in the receptacle (2), characterised in that the device (1) further comprises a stopper (13) mechanically connected to the lid (3) such that, when the lid (3) is in the closed position, the stopper (13) is spaced apart from the port (4) and, when the lid (3) is in the open position, the stopper (13) closes the port (4).

Abstract: The invention relates to a method for increasing the lifespan of animal sperm comprising contacting said sperm with an inhibitor of Slo3 potassium channel. The invention also relates to a use of an inhibitor of Slo3 potassium channel, for increasing the lifespan of animal sperm or motility of capacitated animal sperm, comprising contacting an inhibitor of Slo3 potassium channel with said sperm. Moreover, the invention relates to an artificial insemination instrument for use in artificial insemination of an animal, comprising animal sperm in contact with an inhibitor of Slo3 potassium channel. The invention also relates to a method for artificially inseminating an animal using said artificial insemination instrument. Eventually, the invention relates to a method for increasing the fertility of an animal, comprising contacting sperm of said animal with an inhibitor of Slo3 potassium channel; then artificially inseminating said animal with said sperm.

Abstract: The invention relates to a straw comprising a tube (11) and a gas-permeable and liquid-tight stopper (12), said stopper (12) being arranged in the tube (11), close to an end (16). The invention is characterised in that the stopper (12) comprises an indicator component (20) having a first pre-determined colour in the absence of previous contact with said substance (21) and a second pre-determined colour, of a different shade from that of the first colour, once it has been in contact with said substance (21). The assembly comprises the straw (10) and a device (26) for controlling the filling of the straw.

Abstract: An appliance includes a handle, a speculum tube extending axially from the handle as far as a distal end where it has an opening, a video viewing system having a lens arranged in the speculum tube and a transmission device connected to the lens and connectable to a remote viewing screen, and a lens support for keeping the lens in a predetermined position with respect to the speculum tube, in which position the lens is near the opening and opposite the space situated beyond the opening, characterized in that the speculum tube has an end part and a main part extending between the end part and the handle, the end part being arranged around the support and delimiting the opening, the end part being elastically deformable and the main part being rigid.

Abstract: A straw includes a tube (11), a stopper (13) arranged in the tube and having a passage (35) extending through it, and an emptying needle (14) having a first portion (31) protruding from the stopper as far as a distal end (19) situated in the tube, and a second portion (32) situated in the passage (35) of the stopper, the needle and the stopper forming an insert (12) entirely disposed in the tube and having an internal conduit (24) fluidically connecting the internal spaces of the tube that are situated to either side of the insert, the internal conduit being formed at least in part by the needle. A method for emptying the straw includes establishing a fluidic communication between the needle and a receptacle, and making an opening in the tube in order to connect the dose of liquid-based substance to the atmosphere and allow it to flow.

Abstract: The invention concerns a cryogenic system (1) for vitrifying a substance comprising biological material to be preserved in a receiving region of a thin tube (8), comprising a tank (10) containing a bath (11) of a cryogenic agent and a support member (80) mounted on said tank in a predetermined first position in which said tube is orientated upright, the receiving region being immersed in a liquid zone (17) of said bath, and an opening of said tube being situated above said bath, in a zone of ambient air above said bath, in order to introduce the substance into the tube, the support member being mounted on said tank in a second predetermined position, in which said receiving region is immersed in the liquid zone and said opening is situated immediately above said liquid zone, in a gaseous zone (18) of said bath above said liquid zone and below said zone of ambient air, and being raised from said second position.

Abstract: An actuator assembly includes a primary electrode, a secondary electrode overlapping at least a portion of the primary electrode, and an electroactive polymer layer disposed between the primary electrode and the secondary electrode, where the electroactive polymer layer includes a non-vertical (e.g., sloped) sidewall with respect to a major surface of at least one of the electrodes. The electroactive polymer layer may be characterized by a non-axisymmetric shape with respect to an axis that is oriented orthogonal to an electrode major surface.

Abstract: The assembly comprises a ramp (4) and a straw transfer device (60) comprising two lateral pads and a straw (1) collector arranged between the two lateral pads, the freezer ramp (4) and the transfer device (60) being configured to allow a first end position, to allow a second end position, and such that, by sliding the transfer device (60) from the first end position to the second end position with the pads that slide on angled sections (19) of the ramp (4), the plurality of straws (1) initially arranged on the ramp (4) is recovered in the collector of the transfer device (60).

Abstract: A support element for a plurality of packaging straws, the support element comprising a plate (31) and two flanges (37) rigidly connected to said plate (31) and comprising a fluted surface (53) having a plurality of similar grooves (36), each flange (37) comprising a central part as well as a first projecting part (42) and a second projecting part (43), each extending from one side of the central part, characterised in that the first projecting part comprises a bracket (42) having a bearing face and the second projecting part comprises another bracket (43) having another bearing face, said bearing face and said other bearing face being upwards facing and, in the direction of height, said bearing face being further from said plate (31) than said other bearing face. The assembly comprises the support element and a freezing rack (4).

Abstract: Assembly for handbag multiple straws for packaging animal semen, each having a predetermined diameter and a predetermined length, comprising a freezing ramp (4) that has a rim and a bottom surrounding a central free space (5), said bottom comprising two toothed walls (11, 25) which extend longitudinally along said central free space (5), each torn lied wall (11.25) having a toothing at its top, the toothings of said toothed walls (11, 25) being identical, with each trough being delimited by a surface having a curvature along said predetermined diameter, characterized in that it further comprises a crosspiece (100) comprising parts (103, 104) that are able to move with respect to one another and are configured to permit a position in which said crosspiece (100) is removably joined to said freezing ramp (4) at a location provided to receive at least one said straw (1).

Abstract: The present disclosure relates to a process of manufacturing a moisture-curable adhesive composition, wherein the process comprises the steps of: a) providing a multi-screw extruder comprising a reaction chamber; b) providing reactants and reagents comprising: i. at least one isocyanate; ii. at least one amine; and iii. optionally, at least one plasticizer; c) incorporating the reactants and reagents into the reaction chamber of the multi-screw extruder, thereby forming a reaction product comprising a urea derivative; and d) incorporating at least one moisture-curable prepolymer into the reaction product resulting from step c), thereby forming a moisture-curable adhesive composition. In another aspect, the present disclosure is directed to a moisture-curable adhesive composition obtainable by the process as described above.

Abstract: A method for operating an automation field device comprises connecting a two-conductor line with an input terminal of the field device; setting a minimum electrical current value at the input terminal of the field device in an initializing phase; measuring a maximum voltage value at the input terminal in the initializing phase; ascertaining a minimum supplemental power supplied to the field device at the input terminal and which is available to the field device for performing at least one supplemental functionality; and activating/switching on a supplemental module by the processing unit when the ascertained minimum supplemental power is greater than or equal to an operating power needed for operating the supplemental module, wherein by the activating/switching on of the supplemental module a corresponding supplemental functionality is performed by the field device in measurement operation.

Abstract: A device for preserving a predetermined dose of liquid-based substance, notably animal semen or a preservation medium containing embryos or tissue samples, comprises a tube (11) made of a weldable plastics material. The tube allows a service state in which a receiving portion (21) intended to contain the said predetermined dose has a circular cross-section whereas a sealing portion (22) comprises a welded pinch (19) and a transition zone (23). Over at least part of the sealing portion a differentiating edge region (28) gives the external surface of the tube a visual appearance different from the visual appearance of the external surface of the tube outside of the differentiating edge region. A range comprises such a device and a similar device but without the differentiating edge region.

Abstract: A pro-apoptotic solid dispersion comprises, in essentially non-crystalline form, a Bcl-2 family protein inhibitory compound of Formula I as defined herein, dispersed in a solid matrix that comprises (a) a pharmaceutically acceptable water-soluble polymeric carrier and (b) a pharmaceutically acceptable surfactant. A process for preparing such a solid dispersion comprises dissolving the compound, the polymeric carrier and the surfactant in a suitable solvent, and removing the solvent to provide a solid matrix comprising the polymeric carrier and the surfactant and having the compound dispersed in essentially non-crystalline form therein. The solid dispersion is suitable for oral administration to a subject in need thereof for treatment of a disease characterized by overexpression of one or more anti-apoptotic Bcl-2 family proteins, for example cancer.

Abstract: An example device includes a nanovoided polymer element, a first electrode, and a second electrode. The nanovoided polymer element may be located at least in part between the first electrode and the second electrode. In some examples, the nanovoided polymer element may include anisotropic voids. In some examples, anisotropic voids may be elongated along one or more directions. In some examples, the anisotropic voids are configured so that a polymer wall thickness between neighboring voids is generally uniform. Example devices may include a spatially addressable electroactive device, such as an actuator or a sensor, and/or may include an optical element. A nanovoided polymer layer may include one or more polymer components, such as an electroactive polymer.