Abstract: A medication collection system includes a body, a collection receptacle, a door, a drop box assembly, a scannable indicia, and at least one securing mechanism. The body defines an interior cavity and an exterior. The body includes at least a top panel, a front panel, a back panel, and left and right side panels. The collection receptacle is disposed within the interior cavity. The door allows for access to the collection receptacle. The drop box assembly is attached to the body and disposed above the collection receptacle. The drop box assembly has a door moveable between an open position and a closed position. The scannable indicia is disposed on the exterior of the body and configured to be scanned by a user. At least one securing mechanism is attached to the body to prevent the body from being moved. The medication collection system may include a shredding assembly.