Patents by Inventor Eric Ailor

Eric Ailor has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Antibodies that bind LGR4, their use in inhibiting neoplastic cells and in treating tumors
    Patent number: 9631024
    Abstract: Disclosed herein are anti-LGR4 antibodies for the treatment of cancer. Antibodies disclosed herein may bind LGR4 without disrupting LGR4-RSPO1 binding or signaling, and may disrupt LGR4 signaling through Wnt that is independent of RSPO1. Also disclosed are heavy and light chain polypeptide sequences for antibodies that bind LGR4, for example without disrupting LGR4-RSPO binding or signaling.
    Type: Grant
    Filed: June 17, 2015
    Date of Patent: April 25, 2017
    Assignee: Bionomics, Inc.
    Inventors: Christopher L. Reyes, Kristen M. Smith, Peter Chu, Lioudmila A. Campbell, Eric Ailor
  • ANTIBODIES THAT BIND LGR4
    Publication number: 20160046723
    Abstract: Disclosed herein are anti-LGR4 antibodies for the treatment of cancer. Antibodies disclosed herein may bind LGR4 without disrupting LGR4-RSPO1 binding or signaling, and may disrupt LGR4 signaling through Wnt that is independent of RSPO1. Also disclosed are heavy and light chain polypeptide sequences for antibodies that bind LGR4, for example without disrupting LGR4-RSPO binding or signaling.
    Type: Application
    Filed: June 17, 2015
    Publication date: February 18, 2016
    Inventors: Christopher L. Reyes, Kristen M. Smith, Peter Chu, Lioudmila A. Campbell, Eric Ailor
  • Inhibition of apoptosis process and improvement of cell performance
    Patent number: 7604989
    Abstract: The present invention relates to preventing or delaying programmed cell death by expressing one or more anti-apoptotic polypeptides in a cell such that programmed cell death in the cell is prevented or delayed. The present invention also relates to increasing production of a cell-related product by expressing one or more anti-apoptotic polypeptides in a cell such that production of the cell-related product by the cell is increased. Recombinant cells useful for producing cell-related product or cellular therapy are also provided.
    Type: Grant
    Filed: July 10, 2002
    Date of Patent: October 20, 2009
    Assignees: Johns Hopkins University, Biogen Idec Inc.
    Inventors: Mitchell Reff, Eric Ailor, Michael J. Betenbaugh, Bruno Figueroa, Jr., Marie Hardwick
  • Method to increase protein production in culture
    Publication number: 20050106222
    Abstract: A new recombinant protein production methodology has been discovered for expression of genes of interest. This should be useful for low or poorly expressing genes and in cellular production of high levels of proteins when such high levels may be detrimental or stressful to cells. Isolated polynucleotides encoding a spliced form XBP-1, ATF6, and eIF2? S51A are disclosed. Expression vectors comprising these polynucleotides are useful in increasing the specific cellular productivity in a cell expressing a polypeptide of interest by augmenting the unfolded protein response in a cell. Finally, methods to increase specific cellular productivity in mammalian cells using the above mentioned polynucleotides are also disclosed.
    Type: Application
    Filed: June 10, 2004
    Publication date: May 19, 2005
    Inventors: Eric Ailor, Mitchell Reff
  • Inhibition of apoptosis process and improvement of cell performance
    Publication number: 20030064510
    Abstract: The present invention relates to preventing or delaying programmed cell death by expressing one or more anti-apoptotic polypeptides in a cell such that programmed cell death in the cell is prevented or delayed. The present invention also relates to increasing production of a cell-related product by expressing one or more anti-apoptotic polypeptides in a cell such that production of the cell-related product by the cell is increased. Recombinant cells useful for producing cell-related product or cellular therapy are also provided.
    Type: Application
    Filed: July 10, 2002
    Publication date: April 3, 2003
    Applicant: IDEC Pharmaceuticals Corporation
    Inventors: Mitchell E. Reff, Eric Ailor, Michael J. Betenbaugh, Bruno Figueroa, Marie Hardwick