Abstract: The invention provides for systems, methods, and compositions for targeting nucleic acids. In particular, the invention provides non-naturally occurring or engineered RNA-targeting systems comprising a novel RNA-targeting CRISPR effector protein and at least one targeting nucleic acid component like a guide RNA.

Abstract: One or more embodiments of a burner panel for a metallurgical furnace is described herein. One or more embodiments of a burner panel for a metallurgical furnace are described herein. The sidewall burner pockets have a burner panel therein. The burner panel has a body having an interior face with burner tube disposed therethrough. The burner tube has a first portion and a second portion coupled to the first portion. The burner panel additionally has an internal mounting flange extending along the periphery of the body and overlapping the sidewall, the sidewall and internal mounting flange compressed together by a coupling.

Abstract: A PTC heating module for heating a fluid may include at least one first electrically conductive contact electrode and at least one second electrically conductive contact electrode arranged spaced apart from each other, at least one insulator layer attached to the at least one first contact electrode and the at least one second contact electrode, and at least one PTC thermistor element having a thickness. The at least one PTC thermistor element may have a first main surface and a second main surface disposed opposite each other relative to the thickness. The at least one first contact electrode may be in contact with a contact area of the first main surface and the at least one second contact electrode may be in contact with a contact area of the second main surface. At least one of a clearance distance and a creepage distance may be greater than the thickness.

Abstract: An exhaust gas treatment system for an internal combustion engine with an exhaust gas pathway configured to receive exhaust gas from the internal combustion engine. The system includes a heater operable to heat the exhaust gas as it passes through the exhaust gas pathway, an injector configured to inject reductant into the exhaust gas pathway, a first treatment element positioned in the exhaust gas pathway downstream of the heater and the injector, and a second treatment element positioned in the exhaust gas pathway downstream of the first treatment element. At least one of the first treatment element or the second treatment element includes a selective catalytic reduction (SCR) element, and the exhaust gas treatment system does not include a precious metal catalyst upstream of the first treatment element.

Abstract: A motion detector camera is configured to differentiate between an object or objects passing through the field of view of the camera and an object or objects approaching the sensor. In one example, motion is detected with a camera configured to identify and selectively filter specific directions of motion. The motion detector compares pixel changes, corresponding to the basic area or size of the object, from frame to frame, and detects the amount of increase in change or decrease in change. An increasing change in the area or size of an object indicates that an object is approaching, and a decreasing change in the area or size of an object indicates that an object that is receding.

Abstract: A condenser system that includes a first compressor and a second compressor. An upper coil and a de-superheater coil are fluidly coupled to the first compressor. The upper coil, the de-superheater coil, and the first compressor define a first compressor circuit. A lower coil is fluidly coupled to the second compressor. The lower coil and the second compressor define a second compressor circuit. The upper coil and the de-superheater coil together utilize an entire heat-transfer surface area.

Abstract: Techniques are described for inspecting optical devices, such as eyepieces, to determine whether they exhibit light leakage through an edge sealant that has been applied to the device. Embodiments provide an inspection apparatus that can be employed to detect the leakage of light through an edge sealant of an optical device, where the edge sealant is applied to prevent, or at least reduce, the leakage of light from the optical device. Light from a light source is projected into the optical device. The light can travel along one or more wave guides within the device, until reaching an edge of the device. Light that is able to leak through an edge sealant can be reflected, using mirror(s) in the apparatus, and detected by a camera. Image(s) captured by the camera can be analyzed to determine the performance of the optical device with respect to edge leakage.

Abstract: A first device may establish, with a second device, a short-range wireless communications link. The first device may determine a time interval between each of a set of packets to be transmitted over a short-range wireless communications link with a second device. The first device may encode data with a bitrate that is based on the time interval. The first device may packetize the encoded data in the set of packets. The first device may transmit the set of packets to the second device or the short-range wireless communications link, and each of the set of packets may be separated by the time interval when transmitted.

Abstract: Training a video decoder system comprising, generating at least two sets of video encoding parameters wherein the at least two sets of video encoding parameters are valid, masking a set of the at least two sets of encoding parameters with invalid values to generate an invalid set of video encoding parameters, providing a set of the at least two sets of video encoding parameters to a neural network, training the neural network to predict valid video encoding parameter values for the invalid set using an iterative training algorithm, determining which encoding parameters need to be encoded based on analysis of a prediction error of the trained recurrent neural network, dropping the encoding parameters from the encoded data which are determined to be accurately predicted by the trained recurrent neural network, encoding a new video stream without the dropped encoding parameters. A coder and decoder system with neural network is also disclosed.

Abstract: A circuit for stealing power from an external system without interfering with a communication protocol includes a plurality of wiring connectors configured to receive a plurality of wires, where the plurality of wiring connectors receive a plurality of current levels set by the external system according to the communication protocol; a first voltage regulator to regulate a voltage on the plurality of wiring connectors at a plurality of voltage levels according to the communication protocol; a current monitor to measure the plurality of current levels received through the plurality of wiring connectors; a second voltage regulator that provides a current-limiting output; and a power converter that optimizes an amount of power stolen from the plurality of wiring connectors based on the current-limiting output.

Abstract: The present invention provides for polycrystalline superconducting permanent magnets which are synthesized of doped superconducting (AE) Fe2As2 compounds, where AE denotes an alkaline earth metal, such as Ba, Sr, Mg or Ca. The superconducting permanent magnets of the present invention can be magnetized in their superconducting state by induced currents, resulting in trapped magnetization that scales with the size of the bulk material. The magnitude of the trapped field has been demonstrated to be over 1 T and is predicted to be over 10 T if the technology is scaled, which is much higher than the capabilities of permanent magnets and other superconducting polycrystalline bulks currently known in the art.

Abstract: A method includes moving an actuation lock of a medical injector from a first position to a second position. The actuation lock has an extended portion disposed between a shoulder of a housing and the base when the actuation lock is in the first position. The extended portion is spaced apart from the base when the actuation lock is in the second position. A distal end portion of a base, which is movably coupled to an end portion of the housing, is placed into contact with a body. The base is actuated after the placing to release an energy from an energy storage member within the housing to produce a force to move a needle from a first needle position to a second needle position. At least a portion of the needle extends through the base when the needle is in the second needle position.

Abstract: Systems and methods include providing a helicopter, with a fuselage, a tail boom extending from the fuselage, a main rotor system, and a tail rotor assembly disposed on an aft end of the tail boom. The tail rotor assembly includes a tail rotor housing, at least one normal ducted fan that generate anti-torque thrust to prevent rotation of the fuselage, and at least one canted ducted fan configured to generate both anti-torque thrust to prevent of the fuselage and lift to the tail boom in order to control the pitch of the helicopter. The canted ducted fans generate sufficient lift to prevent a nose-up orientation of the helicopter when the center of gravity of the helicopter is shifted rearward behind the main rotor system, while the normal ducted fans maintain sufficient anti-torque thrust to prevent rotation of the fuselage when the main rotor is operated.

Abstract: A method is provided for testing for presence of a particulate selected from the group consisting of: a microorganism, a fungus, a bacteria, a spore, a virus, a mite, a biological cell, a biological antigen, a protein, a protein antigen, and a carbohydrate antigen. The method includes (a) collecting, in a tube (22), fluid that potentially contains the particulate, (b) using a plunger (24) to push the fluid through a filter (26) disposed at a distal portion of the tube or at a distal end of the plunger, and subsequently, (c) while the filter is inside the tube, ascertaining if any of the particulate was trapped by the filter by applying a particulate-presence-testing-facilitation solution to the filter. Other embodiments are also described.

Abstract: Aspects of the present disclosure include fatty acid ?-hydroxyester compounds (e.g., fatty acid esters of ?-hydroxybutyrate), fatty acid esters of butanediol, and pharmaceutically acceptable salts thereof. Also provided are pharmaceutical compositions having one or more fatty acid ?-hydroxyester compounds and/or one or more fatty acid esters of butanediol. Methods for treating a subject by administering one or more esters to the subject are also provided. Kits containing one or more of the subject esters are also described.

Abstract: A shock absorber includes a first end and a second end that reciprocate relative to one another. The shock absorber includes a gas spring chamber, a damping chamber, and a floating piston. The first side of the floating piston is in fluid communication with the gas spring chamber. The second side of the floating piston is in fluid communication with the damping chamber. The gas in the gas spring chamber applies pressure against the floating piston, which applies pressure to the substantially incompressible fluid in the damping chamber. This pressure transfer may be adequate to minimize or prevent cavitation.

Abstract: A centrifugal impeller shroud assembly has a dynamically moveable impeller shroud for encasing a rotatable centrifugal impeller and resolving misalignment between the impeller shroud and the rotatable centrifugal impeller. The assembly comprises a static casing, an impeller shroud, a shroud arm, and a thermal member. The shroud arm is coupled between the casing and the impeller shroud. The thermal member is coupled to the impeller shroud and has a coefficient of thermal expansion (CTE) lower than the CTE of the shroud. The shroud arm comprises a flexible portion configured to flex responsive to a differential pressure across the shroud arm.

Abstract: An exemplary method for monitoring tire performance includes the steps of providing a wheel assembly comprising a tire and a tire characteristic sensor, providing a vehicle sensor configured to measure a vehicle characteristic, providing a controller in electronic communication with the tire characteristic sensor and the vehicle sensor, receiving, by the controller, tire characteristic data from the tire characteristic sensor and vehicle characteristic data from the vehicle sensor, determining, by the controller, whether a first condition is satisfied, if the first condition is satisfied, monitoring, by the controller, the tire characteristic data, determining, by the controller, an acceleration of the tire from the tire characteristic data, determining, by the controller, whether a second condition is satisfied, and if the second condition is satisfied, generating, by the controller, a control signal.

Abstract: The present disclosure describes the fusogenic promoting activity of the Myomixer protein. This polypeptide, when expressed in non-muscle cells with the Myomaker protein, is able to increase fusion of the cell with a muscle cell, but not with other non-muscle cells, as compared to cells only expression the Myomaker protein. The use of this protein and cells expressing it in the delivery of exogenous genetic material to muscle cells also is described.

Abstract: The present invention relates to methods of screening libraries of chimeric molecules comprising ribotoxic polypeptides, where screening is based on the interim reduction or elimination of ribotoxicity and the methods can identify cytotoxic molecules, each comprising a binding region and a ribotoxic region which jointly possess a desired assay-selectable characteristic, such as, e.g., binding to a target biomolecule, binding to a target cell, and/or cellular internalization.