Abstract: The present invention provides dihydroquinolinone compounds which bind to the ubiquitously expressed E3 ligase protein cereblon (CRBN) and alter the substrate specificity of the CRBN E3 ubiquitin ligase complex, resulting in breakdown of intrinsic downstream proteins. The disclosed compounds are useful for the treatment of cancer.

Abstract: A microfluidic system for performing nucleic acid synthesis includes a microfluidic plate having a reaction chamber coupled to a microfluidic plate input and a microfluidic plate output. A temperature control plate is thermally coupled to the microfluidic plate. A reagent injection plate is coupled to receive enzymatic synthesis reagents. A microvalve plate is coupled between the reagent injection plate and the microfluidic plate input. A controller is coupled the temperature control plate, and the microvalve plate to control the microfluidic system to controllably synthesize nucleic acid sequences.

Abstract: There are provided techniques including a system, method, and computer-readable medium for clock drift monitoring and correction for autonomous vehicles. The method may include the steps of: determining that a first clock or a second clock of a vehicle is unable to synchronize with a common master clock of the vehicle according to a clock synchronization protocol, wherein the first clock and the second clock are associated with a first device and a second device of the vehicle respectively; and in response: determining a first value indicating a relative clock drift between the first clock and the second clock; determining a first time associated with data provided by the second device to the first device, the first time being determined according to the second clock; and determining a corrected first time according to the first clock based at least in part on the first value and the first time.

Abstract: There are provided techniques including a system, method, and computer-readable medium for clock drift monitoring and correction for autonomous vehicles. The method may include the steps of: determining that at least one of a first component associated with a first clock or a second component associated with a second clock of a vehicle is unable to synchronize with a common master clock of the vehicle according to a clock synchronization protocol; operating the first component or the second component without synchronization of the first clock or the second clock with the master clock; determining a first value indicating a relative clock drift between the first clock and the second clock; determining that the first value exceeds a first threshold value; and operating the vehicle in a degraded state or performing a mitigating action based at least in part on determining that the first value exceeds a first threshold value.

Abstract: A radar system is provided based on a core module comprising a radar transducer based on a long, flat platform, provided with coupling elements at each end, which may comprise ISO standard compatible corner fittings as used in freight containers Accessory modules may be connected to the core module by means of these coupling elements at each end. Accessory modules may provide power, communications, cooling or other support functions as required. The coupling achieved between the core module and accessory modules may be reinforced with side brackets, and may be sufficiently strong that the weight of the complete assembly may be supported by the core module, or by the accessory modules. The combined length of the core module and accessory modules may be selected to correspond essentially to the length of a standard freight container, and the length of the core module alone may be selected to correspond to the flat bed of a standard medium truck.

Abstract: The present invention provides dihydroquinolinone compounds which bind to the ubiquitously expressed E3 ligase protein cereblon (CRBN) and alter the substrate specificity of the CRBN E3 ubiquitin ligase complex, resulting in breakdown of intrinsic downstream proteins. The disclosed compounds are useful for the treatment of cancer.

Abstract: The present invention provides selected glutarimides which bind to the ubiquitously expressed E3 ligase protein cereblon (CRBN) and alter the substrate specificity of the CRBN E3 ubiquitin ligase complex, resulting in breakdown of intrinsic downstream proteins. The disclosed compounds are useful for the treatment of cancer.

Abstract: In embodiments, a radio frequency transmitter comprising at least one filtering circuit is provided. The filtering circuit includes a series/parallel shift register comprising a binary input and N binary outputs, with N being an integer greater than or equal to OSR, OSR being an integer greater than or equal to 2. The binary outputs ranging from 0 to N?1, the register receiving a binary data signal at a data frequency on its input and implementing shifts on the N binary outputs at a frequency equal to a multiplier of the data frequency and OSR. The filtering circuit further comprising a first circuit defined by N coefficients Ci. For each non-zero coefficient Ci, a signal determined by the coefficient Ci and by the corresponding one of the binary outputs. The filtering circuit further comprising and an adder circuit delivering an output equal to the sum of analog signals.

Abstract: The present invention provides selected dihydrobenzimidazolones which bind to the ubiquitously expressed E3 ligase protein cereblon (CRBN) and alter the substrate specificity of the CRBN E3 ubiquitin ligase complex, resulting in breakdown of intrinsic downstream proteins. The disclosed compounds are useful for the treatment of cancer.

Abstract: Techniques described are related to determining when a discrepancy between data of multiple sensors (e.g., IMUs) might be attributable to a sensor error, as opposed to operating conditions, such as sensor bias or noise. For example, the sensor data is passed through one or more filters (e.g., bandpass filter) that model the bias or noise, and the filtered data may then be compared for consistency. In some examples, consistency may be based on residuals or some other metric describing discrepancy among the filtered sensor data.

Abstract: The present invention provides selected glutarimides which bind to the ubiquitously expressed E3 ligase protein cereblon (CRBN) and alter the substrate specificity of the CRBN E3 ubiquitin ligase complex, resulting in breakdown of intrinsic downstream proteins. The disclosed compounds are useful for the treatment of cancer.

Abstract: The present invention provides selected dihydrobenzimidazolones which bind to the ubiquitously expressed E3 ligase protein cereblon (CRBN) and alter the substrate specificity of the CRBN E3 ubiquitin ligase complex, resulting in breakdown of intrinsic downstream proteins. The disclosed compounds are useful for the treatment of cancer.

Abstract: In an embodiment a device includes a first circuit and a second circuit, wherein the first circuit is configured to generate a fourth signal and a fifth signal by applying the phase shift respectively to a first signal and to a second signal and deliver a sixth signal corresponding to a sampling over one bit of the fourth signal, a seventh signal corresponding to a sampling over one bit of the fifth signal, an eighth signal corresponding to a sampling over one bit of a difference between the fourth and fifth signals, and a ninth signal corresponding to a sampling over one bit of a sum between the fourth and fifth signals, wherein the second circuit is configured to receive the sixth, seventh, eighth, and ninth signals and determine, during a first phase where the first and second signals are representative of a first known symbol of a QPSK constellation, a state of a first bit from among a first state and a second state based on the eighth and ninth signals.

Abstract: The present invention provides dihydroquinolinone compounds which bind to the ubiquitously expressed E3 ligase protein cereblon (CRBN) and alter the substrate specificity of the CRBN E3 ubiquitin ligase complex, resulting in breakdown of intrinsic downstream proteins. The disclosed compounds are useful for the treatment of cancer.

Abstract: A radar system is provided based on a core module comprising a radar transducer based on a long, flat platform, provided with coupling elements at each end, which may comprise ISO standard compatible corner fittings as used in freight containers Accessory modules may be connected to the core module by means of these coupling elements at each end. Accessory modules may provide power, communications, cooling or other support functions as required. The coupling achieved between the core module and accessory modules may be reinforced with side brackets, and may be sufficiently strong that the weight of the complete assembly may be supported by the core module, or by the accessory modules. The combined length of the core module and accessory modules may be elected to correspond essentially to the length of a standard freight container, and the length of the core module alone may be selected to correspond to the flat bed of a standard medium truck.

Abstract: In an embodiment a device includes a first circuit and a second circuit, wherein the first circuit is configured to generate a fourth signal and a fifth signal by applying the phase shift respectively to a first signal and to a second signal and deliver a sixth signal corresponding to a sampling over one bit of the fourth signal, a seventh signal corresponding to a sampling over one bit of the fifth signal, an eighth signal corresponding to a sampling over one bit of a difference between the fourth and fifth signals, and a ninth signal corresponding to a sampling over one bit of a sum between the fourth and fifth signals, wherein the second circuit is configured to receive the sixth, seventh, eighth, and ninth signals and determine, during a first phase where the first and second signals are representative of a first known symbol of a QPSK constellation, a state of a first bit from among a first state and a second state based on the eighth and ninth signals.

Abstract: A method for facilitating predictive caching of data is provided. The method includes retrieving raw data relating to user activity for a plurality of users, the user activity including a history of web resources accessed by a user; converting the raw data into a structured data set based on a predetermined criterion; generating a model based on the structured data set; training the model by using a training data set, the training data set including the user activity for a predetermined period of time; determining, by using the trained model, a predicted first web resource for the user; and automatically caching, in a memory, the predicted first web resource.

Abstract: The present invention provides selected dihydrobenzimidazolones which bind to the ubiquitously expressed E3 ligase protein cereblon (CRBN) and alter the substrate specificity of the CRBN E3 ubiquitin ligase complex, resulting in breakdown of intrinsic downstream proteins. The disclosed compounds are useful for the treatment of cancer.

Abstract: A wireless communication system is provided including a first media device, a second media device, and a third media device, each media device configured to output media content. The first media device is designated as an access point media device that is configured to transmit media content to the second media device and the third media device. The first media device is configured to transmit the media content to the second media device using simplex communication instead of duplex communication based on a first confidence level indicator received from the second media device indicating a high level of confidence. The first media device is configured to transmit the media content to the third media device using duplex communication based on a second confidence level indicator received from the third media device a high level of confidence, and each media device is configured to output the media content in a synchronized manner.

Abstract: A wireless communication system is provided including a group of media devices that includes a first media device, a second media device, a third media device, and a fourth media device. The first media device, during a first time period, is designated as an access point media device that is configured to transmit media content to each of the other media devices in the group. The second media device is configured to become the access point media device during a second time period and transmit media content to each of the other media devices in the group based on a determination that the second media device is better suited than the first media device to be the access point media device for the group during the second time period. Each media device is configured to output the media content transmitted by the access point media device in a synchronized manner.