Abstract: The current invention is in the field of molecular biology/pharmacology and provides methods of using compounds that modulate the effects of GPR30/GPER for treating obesity and diabetes (preferably agonists) as well as disease states and/or conditions that result from excessive formation of reactive oxygen species (preferably antagonists). These compounds may function as agonists and/or antagonists of the disclosed estrogen receptor and/or modulate the expression/upregulation of nox and nox-associated reactive oxygen species (ROS).

Abstract: A cartridge dispenser having a rotatable sleeve for alerting a person as to when a cartridge dispenser should be replaced based on when the cartridge dispenser is placed in a body of water with the cartridge replacement date carried forward on the cartridge dispenser.

Abstract: A dispenser securable in a hostile environment of a body of recreational water with the dispenser having a dispersant chamber with a dispersant therein isolated from the hostile water environment proximate the dispenser to enable dispenser placement in various locations within the body of recreational water without adversely affecting a dispenser dispersant rate.

Abstract: An inline filterwell system with a floating weir that delivers a dispersant into the water in an inline filterwell where a cartridge dispenser dispersant rate of a cartridge dispenser located in a cartridge jacket of the weir is isolated from changes in the velocity of water flowing through an open body of the weir.

Abstract: A filterwell cartridge having ports for dispensing a dispersant directly into a filterwell of a hot tub, spa or the like with the filterwell cartridge peripherally and postionally supportable in a quick release mode through facial engagement of compound surfaces located on opposite sides of the filterwell cartridge.

Abstract: A dispensing system comprising a housing supporting a first cartridge and a second dispensing cartridge where the first cartridge is positionable in a first compartment of the housing but not in a second compartment of the housing to prevent a change in an axial position of the first cartridge and the second dispensing when a cartridge is replaced in the housing.

Abstract: An inline dispensing system having a collar engageable with an inline well to support an inline cap thereon and for directing a cartridge carrier into a sealing relation therewith as a cartridge carrier is inserted into an inline well in a container of a body of recreational water.

Abstract: A floating dispenser holder having a platform supporting a dispensing cartridge in a dispensing condition and a canopy extending over the dispensing cartridge located on the platform.

Abstract: A system and method for efficiently storing and accessing large volumes of metadata persistent on Non-Volatile Memory (NVM) storage systems is provided. The system applies log-structured, Copy-on-Write (CoW) B+ tree methods, and supports a core-affine data and resource partitioning approaches on the system's architecture and platform with a high-degree of parallelism within the CPU, NVMe storage, and networking devices. The subject system and method efficiently indexes both in-core (DRAM resident) and out-of-core (NVM resident) metadata, supports a variety of data access patterns, supports CoW features and provides verifiable data safety and integrity capabilities. The present system minimizes latencies over all aspects of the metadata management and access path by leveraging core-affine resource partitioning with runtime environment providing lightweight user-level threads with low-latency context switching that execute within the exclusive context of a dedicated CPU core, and partitioned resources.

Abstract: A filter well mountable dispenser holder securable within a hot tub filter well with the dispenser holder supporting replaceable dispersant containing dispensing cartridges positionable within a circulating flow of water through the filter well to thereby release dispersants therefrom without preventing the circulating flow of water from passing through the filter media proximate the dispensing cartridges.

Abstract: A filterwell cartridge holder having a face for compressible engaging pleats on a water filter cartridge and a further face holding a dispensing cartridge thereon in a position to release dispersants into a filterwell containing a water filter cartridge.

Abstract: A filterwell cartridge holder mountable within a hot tub filterwell with the filterwell cartridge holder having a handhold on one end and a feed pipe connector on an opposite end that is attachable to or removable from a filterwell feed pipe with the filterwell cartridge holder engaging and supporting dispensing cartridges thereon to maintain the dispensing cartridges in a dispensing mode within the filterwell.

Abstract: A wireless occupancy sensor that is configured to be deployed within a building space includes a sensor body, an occupancy sensor that is housed by the sensor body, a light emitting diode (LED) that is housed by the sensor body, a wireless transceiver that is housed by the sensor body and is configured to be in wireless communication with a remote device. A controller is housed by the sensor body and is operably coupled to the occupancy sensor, the LED and the wireless transceiver and is configured to receive via the wireless transceiver a request to illuminate the LED from the remote device and in response to receiving the request, illuminate the LED in order to help visually identify the wireless occupancy sensor in the building space.

Abstract: A system and method for efficiently storing and accessing large volumes of metadata persistent on Non-Volatile Memory (NVM) storage systems is provided. The system applies log-structured, Copy-on-Write (CoW) B+ tree methods, and supports a core-affine data and resource partitioning approaches on the system's architecture and platform with a high-degree of parallelism within the CPU, NVMe storage, and networking devices. The subject system and method efficiently indexes both in-core (DRAM resident) and out-of-core (NVM resident) metadata, supports a variety of data access patterns, supports CoW features and provides verifiable data safety and integrity capabilities. The present system minimizes latencies over all aspects of the metadata management and access path by leveraging core-affine resource partitioning with runtime environment providing lightweight user-level threads with low-latency context switching that execute within the exclusive context of a dedicated CPU core, and partitioned resources.

Abstract: A filter well mountable dispenser holder securable within a hot tub filter well with the dispenser holder supporting replaceable dispersant containing dispensing cartridges positionable within a circulating flow of water through the filter well to thereby release dispersants therefrom without preventing the circulating flow of water from passing through the filter media proximate the dispensing cartridges.

Abstract: A filter well mountable dispenser holder securable within a hot tub filter well with the dispenser holder supporting replaceable dispersant containing dispensing cartridges positionable within a circulating flow of water through the filter well to thereby release dispersants therefrom without preventing the circulating flow of water from passing through the filter media proximate the dispensing cartridges.