Abstract: Methods including drying a crude mineral composition comprising surface active minerals (“SAM”) and gangue, grinding the crude mineral composition to produce a crude mineral particulate composition comprising SAM particulates and gangue particulates, contacting the crude mineral particulate composition with a quaternary ammonium surfactant to form organically modified surface active mineral (“OMSAM”) particulates, grinding the crude mineral particulate composition that was contacted with the quaternary ammonium surfactant, and separating a portion of the OMSAM particulates from the gangue particulates using an air classifier.

Abstract: The invention relates to solid compositions comprising {2-[3-cyclohexyl-3-(trans-4-propoxy-cyclohexyl)-ureido]-thiazol-5-ylsulfanyl}-acetic acid, and methods of making and using such solid compositions.

Abstract: The invention provides tris(hydroxymethyl)aminomethane salts of a small-molecule GLP1R agonist. The invention further provides solid compositions comprising tris(hydroxymethyl)aminomethane salts of a small-molecule GLP1R agonist. The invention further provides uses of tris(hydroxymethyl)aminomethane salts of a small-molecule GLP1R agonist, e.g., for treating type 1 diabetes, type 2 diabetes, or obesity.

Abstract: The invention provides tris(hydroxymethyl)aminomethane salts of a small-molecule GLP1R agonist. The invention further provides solid compositions comprising tris(hydroxymethyl)aminomethane salts of a small-molecule GLP1R agonist. The invention further provides uses of tris(hydroxymethyl)aminomethane salts of a small-molecule GLP1R agonist, e.g., for treating type 1 diabetes, type 2 diabetes, or obesity.

Abstract: An electroacoustic channel soundfield is altered. An audio signal is applied by an electromechanical transducer to an acoustic space, causing air pressure changes therein. Another audio signal is obtained by a second electromechanical transducer, responsive to air pressure changes in the acoustic space. A transfer function estimate of the electroacoustic channel is established, responsive to the second audio signal and part of the first audio signal. The transfer function estimate is derived to be adaptive to temporal variations in the electroacoustic channel transfer function. Filters are obtained with transfer functions based on the transfer function estimate. Part of the first audio signal is filtered therewith.

Abstract: Biodegradable organophilic clays for use in drilling fluids may, in some instances, include clay treated with a surfactant system that includes biodegradable quaternary ammonium surfactants and nonbiodegradable quaternary ammonium surfactants. The biodegradable quaternary ammonium surfactant may be capable of degrading by more than about 90% over 28 days as determined by Method 306 of the OECD Guidelines for the Testing of Chemical.

Abstract: An electroacoustic channel soundfield is altered. An audio signal is applied by an electromechanical transducer to an acoustic space, causing air pressure changes therein. Another audio signal is obtained by a second electromechanical transducer, responsive to air pressure changes in the acoustic space. A transfer function estimate of the electroacoustic channel is established, responsive to the second audio signal and part of the first audio signal. The transfer function estimate is derived to be adaptive to temporal variations in the electroacoustic channel transfer function. Filters are obtained with transfer functions based on the transfer function estimate. Part of the first audio signal is filtered therewith.

Abstract: The invention provides solid compositions comprising (S)-3-(4?-Cyano-biphenyl-4-yl)-2-{[(3S,7S)-3-[4-(3,4-dichloro-benzyloxy)-phenyl]-1-methyl-2-oxo-6-((S)-1-phenyl-propyl)-2,3,5,6,7,8-hexahydro-1H-4-oxa-1,6-diaza-anthracene-7-carbonyl]-amino}-propionic acid (OC-1) or a salt thereof and methods of making and using those compositions. The invention also provides the monohydrochloride salt of (S)-3-(4?-Cyano-biphenyl-4-yl)-2-{[(3S,7S)-3-[4-(3,4-dichloro-benzyloxy)-phenyl]-1-methyl-2-oxo-6-((S)-1-phenyl-propyl)-2,3,5,6,7,8-hexahydro-1H-4-oxa-1,6-diaza-anthracene-7-carbonyl]-amino}-propionic acid.

Abstract: A search and a browse on a single user query is performed. A refined query is selected from the results of the first user query. Thereafter, a list of concepts from a first directory associated with the refined query is obtained. The concepts are defined in a hierarchical relationship with concepts having broader scope being higher in the hierarchy and concepts having a narrower scope being lower in the hierarchy. Additionally, a list of web sites associated with the search concept is obtained from a second directory.

Abstract: An apparatus, system, and method are disclosed for enhancing help resource selection for a user that accesses a help function within a computer application. The method of enhancing the help resource selection comprises determining a list of help resources applicable to the current context of the user interaction with the computer application and the help feature. Then, the method ranks applicable help resources according to relevance criteria set by the practitioner of the invention. For example, the practitioner may wish to provide certain help resources based upon the skill level of the user and whether the user has accessed specific help resources in the past. The method would preferentially select those help resources that matched the user skill level and past access criteria set by the practitioner.

Abstract: The present invention provides an amorphous form of rapamycin 42-ester with 3-hydroxy-2-(hydroxymethyl)-2-methylpropionic acid. This invention also provides processes for preparing the amorphous form and pharmaceutical compositions including the amorphous form.

Abstract: Disclosed are RAGE fusion proteins comprising RAGE polypeptide sequences linked to a second, non-RAGE polypeptide. The RAGE fusion protein may utilize a RAGE polypeptide domain comprising a RAGE ligand binding site and an interdomain linker directly linked to the N-terminus of an immunoglobulin CH2 domain. Also disclosed are RAGE fusion protein formulations and the use of the RAGE fusion proteins and RAGE fusion protein formulations as therapeutics for RAGE-mediated pathologies.

Abstract: An computer program product, a system, and method are disclosed for providing a training service. Delivery of the training service comprises selecting an input file comprising a plurality of presentation options, a plurality of mode definitions and a transform module. The transform module comprises transform logic configured to act upon content of an input file to present the input file to a user differently according to characteristics of a selected mode definition. Delivery of the training service further comprises receiving an input file selection and a mode definition selection. In addition, the transform module dynamically generates an output format for presentation of the content of the input file. The output format is generated by the transform logic as determined by the characteristics of the selected mode definition.

Abstract: An apparatus, system, and method are disclosed for enhancing help resource selection for a user that accesses a help function within a computer application. The method of enhancing the help resource selection comprises determining a list of help resources applicable to the current context of the user interaction with the computer application and the help feature. Then, the method ranks applicable help resources according to relevance criteria set by the practitioner of the invention. For example, the practitioner may wish to provide certain help resources based upon the skill level of the user and whether the user has accessed specific help resources in the past. The method would preferentially select those help resources that matched the user skill level and past access criteria set by the practitioner.

Abstract: The present invention relates to crystalline Forms of 3-biphenyl-4-yl-(2S)-[(4?-trifluoromethyl-biphenyl-4-carbonyl)-amino]-propionic acid. In one embodiment, the present invention provides polymorphic Forms I, II, and III of 3-biphenyl-4-yl-(2S)-[(4?trifluoromethyl-biphenyl-4-carbonyl)-amino]-propionic acid.

Abstract: The present invention provides compositions, useful as pharmaceuticals, comprising 3-biphenyl-4-yl-(2S)-[(4?-trifluoromethyl-biphenyl-4-carbonyl)-amino]-propionic acid. Also disclosed are methods for preparing the compositions and methods for using the compositions.

Abstract: A CCI-779 oral dosage form is provided in which, after oral administration to a subject, the CCI-779 has a whole blood peak concentration (Cmax) of 5.4±1.8 ng/mL and an area under the curve (AUC) of about 66±about 22 ng-hr/ml and the sirolimus has a Cmax of 18.7±9.6 ng/mL and an AUC of about 600±about 228 ng-hr/ml, for a 25 mg unit dose of CCI-779. Another CCI-779 oral dosage form is provided which, after oral administration thereof to a subject, the CCI-779 has a Cmax of 5.7±1.7 ng/mL and an AUC of about 60±about 20 ng-hr/ml and the sirolimus has a Cmax of 17.1±8.1 ng/mL and an AUC of about 548±about 187 ng-hr/ml in whole blood, for a 25 mg unit dose of CCI-779. Products containing these oral dosage forms, and methods of use thereof, are also described.

Abstract: A search and a browse on a single user query is performed. A refined query is selected from the results of the first user query. Thereafter, a list of concepts from a first directory associated with the refined query is obtained. The concepts are defined in a hierarchical relationship with concepts having broader scope being higher in the hierarchy and concepts having a narrower scope being lower in the hierarchy. Additionally, a list of web sites associated with the search concept is obtained from a second directory.

Abstract: Micronized CCI-779 is described. This directly compressible rapamycin 42-ester with 3-hydroxy-2-(hydroxymethyl)-2-methylpropionic acid provides a convenient and effective method to deliver therapeutic levels of CCI-779 to a patient.