Abstract: A device can include a capsule containing an array of microneedles and a mechanical actuator. The device can be in an ingestible form for delivery to a duodenum or other target location within a subject and can release a first shell portion and a second shell portion of the capsule from one another in response to stimuli or conditions in or en route to the duodenum or other target location. The launcher can drive the released first shell portion and the second shell portion away from one another to expose the array of microneedles in a position for achieving penetrating engagement with a lining of the duodenum or other target location. The penetrating engagement can facilitate delivery of a biotherapeutic agent or other payload via the microneedles.

Abstract: A retinal imaging system and a retinal imaging adaptor and related methods of use are described. In an embodiment; the retinal imaging system comprises a monocular image sensor adapted to acquire a retinal image of an eye; and a binocular eye piece configured to slide relative to the monocular image sensor and shaped to couple to a face of a user. In an embodiment, the monocular image sensor is positioned to acquire a first retinal image of a first eye of the user in a first position of the binocular eye piece and to acquire a second retinal image of a second eye of the user in a second position of the binocular eye piece. In an embodiment, the retinal imaging system includes a sliding bracket coupled to a housing of the retinal imaging system and slidably coupled to the binocular eye piece.

Abstract: Apparatuses, machine-accessible storage media, and methods for noninvasively measuring a heart performance metric, such as left ventricular filling pressure, are described. In an embodiment, the apparatus includes a housing shaped to be grasped by a hand; a tower protruding from a surface of the housing positioned to conform to a finger of the hand when grasping the housing; a tactile sensor disposed on a curved surface of the tower and adapted to measure blood pressure pulsatility in a digital artery of the finger and output pulsatility signals indicative of the blood pressure pulsatility; a graphical user interface for orchestrating a test of the performance metric of the heart and displaying results of the test.

Abstract: A device can include a capsule containing an array of microneedles and a mechanical actuator. The device can be in an ingestible form for delivery to a duodenum or other target location within a subject and can release the mechanical actuator from constraint by the capsule in response to stimuli or conditions in or en route to the duodenum or other target location. The mechanical actuator upon release from constraint by the capsule can expand outwardly (e.g., responsive to a bias provided by a flexibly resilient material of the mechanical actuator) in a direction away from a central longitudinal axis of the mechanical actuator and drive the array of microneedles into penetrating engagement with a lining of the duodenum or other target location. The penetrating engagement can facilitate delivery of a biotherapeutic agent or other payload via the microneedles.

Abstract: According to an embodiment of the disclosure, a method of creating an object with a conduit is disclosed. A material is deposited on a sacrificial collector; and, the sacrificial collector is then removed to create the object with the conduit. Both the object and the sacrificial collector can approximate the shape of desired blood vessel. The method can also include a 3-D printing of the desired shape of the mold and utilization of gallium as the sacrificial collector. The sacrificial object is created by insertion of the gallium in the mold. After removal of the gallium from the mold, fibers are electrospun onto the gallium. The gallium is removed through melting—leaving a scaffold, the object with the conduit. In addition to the gallium, an extra sacrificial layer of a water-soluble material may be utilized.

Abstract: Apparatuses, machine-accessible storage media, and methods for noninvasively measuring a heart performance metric, such as left ventricular filling pressure, are described. In an embodiment, the apparatus includes a housing shaped to be grasped by a hand; a tower protruding from a surface of the housing positioned to conform to a finger of the hand when grasping the housing; a tactile sensor disposed on a curved surface of the tower and adapted to measure blood pressure pulsatility in a digital artery of the finger and output pulsatility signals indicative of the blood pressure pulsatility; a graphical user interface for orchestrating a test of the performance metric of the heart and displaying results of the test.

Abstract: Apparatuses, machine-accessible storage media, and methods for noninvasively measuring a heart performance metric, such as left ventricular filling pressure, are described. In an embodiment, the apparatus includes a housing shaped to be grasped by a hand; a tower protruding from a surface of the housing positioned to conform to a finger of the hand when grasping the housing; a tactile sensor disposed on a curved surface of the tower and adapted to measure blood pressure pulsatility in a digital artery of the finger and output pulsatility signals indicative of the blood pressure pulsatility; a graphical user interface for orchestrating a test of the performance metric of the heart and displaying results of the test.

Abstract: A communication system provides multimedia communications within and between armored ground combat vehicles (GCVs). The system includes client computers within the armored GCVs providing distributed and interconnected multimedia communications among the client computers. The multimedia communication may include a one-to-one communication, a text communication to a group, an audio communication to a group, or a video communication to a group. Logic providing the distributed and interconnected multimedia communications is not located at a single client computer. The client computers display graphical user interfaces (GUIs) enabling soldiers to select parameters of the communication system with some GUIs providing presence discovery among the armored GCVs. One of the plurality of client computers acts as an origination station and other client computers may be configured as receiving communication station(s).

Abstract: A communication system provides multimedia communications within and between armored ground combat vehicles (GCVs). The system includes client computers within the armored GCVs providing distributed and interconnected multimedia communications among the client computers. The multimedia communication may include a one-to-one communication, a text communication to a group, an audio communication to a group, or a video communication to a group. Logic providing the distributed and interconnected multimedia communications is not located at a single client computer. The client computers display graphical user interfaces (GUIs) enabling soldiers to select parameters of the communication system with some GUIs providing presence discovery among the armored GCVs. One of the plurality of client computers acts as an origination station and other client computers may be configured as receiving communication station(s).

Abstract: A communication system provides multimedia communications within and between armored ground combat vehicles (GCVs). The system includes client computers within the armored GCVs providing distributed and interconnected multimedia communications among the client computers. The multimedia communication may include a one-to-one communication, a text communication to a group, an audio communication to a group, or a video communication to a group. Logic providing the distributed and interconnected multimedia communications is not located at a single client computer. The client computers display graphical user interfaces (GUIs) enabling soldiers to select parameters of the communication system with some GUIs providing presence discovery among the armored GCVs. One of the plurality of client computers acts as an origination station and other client computers may be configured as receiving communication station(s).

Abstract: According to an embodiment of the disclosure, a method of creating an object with a conduit is disclosed. A material is deposited on a sacrificial collector; and, the sacrificial collector is then removed to create the object with the conduit. Both the object and the sacrificial collector can approximate the shape of desired blood vessel. The method can also include a 3-D printing of the desired shape of the mold and utilization of Gallium as the sacrificial collector. The sacrificial object is created by insertion of the gallium in the mold. After removal of the gallium from the mold, fibers are electrospun onto the gallium. The gallium is removed through melting—leaving a scaffold, the object with the conduit. In addition to the gallium, an extra sacrificial layer of a water-soluble material may be utilized.

Abstract: A device can include a capsule containing an array of microneedles and a mechanical actuator. The device can be in an ingestible form for delivery to a duodenum or other target location within a subject and can release the mechanical actuator from constraint by the capsule in response to stimuli or conditions in or en route to the duodenum or other target location. The mechanical actuator upon release from constraint by the capsule can expand outwardly (e.g., responsive to a bias provided by a flexibly resilient material of the mechanical actuator) in a direction away from a central longitudinal axis of the mechanical actuator and drive the array of microneedles into penetrating engagement with a lining of the duodenum or other target location. The penetrating engagement can facilitate delivery of a biotherapeutic agent or other payload via the microneedles.

Abstract: A dosage measurement system is adapted to receive a motion from a dosage injection mechanism disposed within a drug injection pen. The dosage measurement system includes a substrate, a sensing capacitor disposed on the substrate, and a lifting tab. The sensing capacitor includes a dielectric layer disposed between a base plate and an adjustable plate. The lifting tab is attached to the adjustable plate and positioned to engage an undulation pattern disposed on a component attached to the dosage injection mechanism. The lifting tab is adapted to physically change a separation distance between the adjustable plate and the base plate in a reciprocal manner in response to the motion of the dosage injection mechanism and engagement with the undulation pattern. A capacitance of the sensing capacitor changes in response to the engagement of the lifting tab with the undulation pattern and the motion of the dosage injection mechanism.

Abstract: The present invention is directed to antibodies, and antigen-binding portions thereof, engineered to introduce amino acids for site-specific conjugation. The invention relates to engineered antibody constant region (Fc, C?, C?, and C?) polypeptides, and portions thereof, and antibodies comprising the polypeptides. Further, the invention relates to Fc fusion proteins comprising an engineered Fc region. The invention also relates to methods and uses of the engineered antibodies and portions for, among other things, production of antibody-drug conjugate therapeutics.

Abstract: The present invention relates to a mammalian cell comprising a gene encoding a polypeptide of interest, wherein the polypeptide of interest is expressed comprising one or more posttranslational modification patterns. These modifications are useful for example in glycoprotein production where the antibodies with the modifications have an enhanced antibody-dependent cell-mediated cytotoxicity (ADCC). The present invention also relates to methods for producing the glycoproteins and compositions comprising the glycoproteins, and their uses.