Abstract: The present disclosure provides interferon receptor agonists with improved safety profiles and therapeutic indices. The interferon receptor agonists are attenuated through masking and/or reduced receptor binding as compared to a wild-type interferon. IFN receptor agonists optionally further comprise a targeting moiety, e.g., a targeting moiety that recognizes a tumor- or immune cell-associated antigen and directs the interferon receptor agonist to a tumor site and/or tumor-reactive immune cells. The disclosure further provides pharmaceutical compositions comprising the interferon receptor agonists, and methods of use of the interferon receptor agonists in therapy, as well as nucleic acids encoding the interferon receptor agonists, recombinant cells that express the interferon receptor agonists and methods of producing the interferon receptor agonists.

Abstract: The present disclosure provides interferon receptor agonists with improved safety profiles and therapeutic indices. The interferon receptor agonists are attenuated through masking and/or reduced receptor binding as compared to a wild-type interferon. IFN receptor agonists optionally further comprise a targeting moiety, e.g., a targeting moiety that recognizes a tumor- or immune cell-associated antigen and directs the interferon receptor agonist to a tumor site and/or tumor-reactive immune cells. The disclosure further provides pharmaceutical compositions comprising the interferon receptor agonists, and methods of use of the interferon receptor agonists in therapy, as well as nucleic acids encoding the interferon receptor agonists, recombinant cells that express the interferon receptor agonists and methods of producing the interferon receptor agonists.

Abstract: Metal-organic frameworks of the family M2 (2,5-dioxido-1,4-benzenedicarboxylate) wherein M=Mg, Mn, Fe, Co, Cu, Ni or Zn are a group of porous crystalline materials formed of metal cations or clusters joined by multitopic organic linkers that can be used to isolate individual gases from a stream of combined gases. This group of adsorbant materials incorporates a high density of coordinatively-unsaturated MII centers lining the pore surfaces. These adsorbents are particularly suited for selective carbon dioxide/monoxide adsorption via pressure swing adsorption near temperatures of 313 K since they selectively adsorb carbon dioxide at high pressures in the presence of hydrogen, and desorb carbon dioxide upon a pressure decrease. The redox-active FeII centers in Fe2(dobdc) can be used for the separation of O2 from N2 and other separations based on selective, reversible electron transfer reactions.

Abstract: A data processing apparatus, comprising at least one processor and a traffic monitor comprising logic which, when executed by the processor, causes the processor to perform: creating, using forward Domain Name System (DNS) lookups, a mapping of domain names to Internet Protocol (IP) addresses; determining whether a particular domain in the mapping requires handling data traffic to or from the particular domain by performing a particular action; based on the mapping, determining one or more IP addresses that are associated with the particular domain; generating policy for a firewall that instructs the firewall to perform the particular action upon receiving a particular request; wherein the particular request specifies a particular IP address that is within the particular domain.

Abstract: A method and apparatus for controlling access to network resources referenced in electronic mail messages comprises the computer-implemented steps of receiving an electronic mail message that comprises one or more hyperlinks; determining sender information that identifies a sender of the electronic mail message; creating and storing a record that associates the sender information with each of the one or more hyperlinks; receiving a request to access a specified hyperlink among the one or more hyperlinks; retrieving, based on the specified hyperlink, the record; retrieving, based on the sender information associated with the specified hyperlink, sender reputation information associated with the sender; determining, based on the sender reputation information, a particular action among a plurality of allowed actions; and issuing a network request to access the specified hyperlink only when the particular action is allowing user access to the specified hyperlink.

Abstract: A data processing apparatus, comprising at least one processor and a traffic monitor comprising logic which, when executed by the processor, causes the processor to perform: creating, using forward Domain Name System (DNS) lookups, a mapping of domain names to Internet Protocol (IP) addresses; determining whether a particular domain in the mapping requires handling data traffic to or from the particular domain by performing a particular action; based on the mapping, determining one or more IP addresses that are associated with the particular domain; generating policy for a firewall that instructs the firewall to perform the particular action upon receiving a particular request; wherein the particular request specifies a particular IP address that is within the particular domain.

Abstract: A method and apparatus for controlling access to network resources referenced in electronic mail messages comprises the computer-implemented steps of receiving an electronic mail message that comprises one or more hyperlinks; determining sender information that identifies a sender of the electronic mail message; creating and storing a record that associates the sender information with each of the one or more hyperlinks; receiving a request to access a specified hyperlink among the one or more hyperlinks; retrieving, based on the specified hyperlink, the record; retrieving, based on the sender information associated with the specified hyperlink, sender reputation information associated with the sender; determining, based on the sender reputation information, a particular action among a plurality of allowed actions; and issuing a network request to access the specified hyperlink only when the particular action is allowing user access to the specified hyperlink.

Abstract: A data processing apparatus can perform HTTP traffic monitoring and filtering of HTTP requests from clients and responses from servers. Example apparatus comprises a processor, a first network interface to a protected network, a second network interface to an external network, and a traffic monitor having an address-domain name database, a firewall rules manager, and a DNS snooper. The traffic monitor accesses a blacklist and can perform receiving, from a client computer, a request to access a resource in the external network; blocking the request to the resource when a user agent of the client is in the blacklist as malicious software or when a file extension in a response to the request is in the blacklist; requesting, from a web reputation service, and receiving a reputation score indicating a reputation of the resource; blocking sending the request to the resource when the reputation is below a specified threshold.

Abstract: A data processing apparatus can perform HTTP traffic monitoring and filtering of HTTP requests from clients and responses from servers. Example apparatus comprises a processor; a first network interface to a protected network; a second network interface to an external network; a core hypertext transfer protocol (HTTP) proxy coupled to the processor and coupled to a content cache, wherein the HTTP proxy is configured to receive an HTTP request from a client computer in the protected network, send the request to a network resource in the external network on behalf of the client, and receive an HTTP response from the network resource on behalf of the client computer; and a plurality of spyware scanning engines (SSEs), wherein each of the SSEs is coupled to stored content signatures, and wherein each of the SSEs is configured to detect a particular kind of malicious software in an HTTP response.

Abstract: A method and apparatus for controlling access to network resources referenced in electronic mail messages comprises the computer-implemented steps of receiving an electronic mail message that comprises one or more hyperlinks; determining sender information that identifies a sender of the electronic mail message; creating and storing a record that associates the sender information with each of the one or more hyperlinks; receiving a request to access a specified hyperlink among the one or more hyperlinks; retrieving, based on the specified hyperlink, the record; retrieving, based on the sender information associated with the specified hyperlink, sender reputation information associated with the sender; determining, based on the sender reputation information, a particular action among a plurality of allowed actions; and issuing a network request to access the specified hyperlink only when the particular action is allowing user access to the specified hyperlink.

Abstract: A method and apparatus for controlling access to network resources referenced in electronic mail messages comprises the computer-implemented steps of receiving an electronic mail message that comprises one or more hyperlinks; modifying the one or more hyperlinks by associating an identifier value with each of the one or more hyperlinks; receiving a request to access a specified hyperlink among the one or more hyperlinks; determining, based on the identifier value that is associated with the specified hyperlink, a particular action among a plurality of allowed actions; and issuing a network request to access the specified hyperlink only when the particular action is allowing user access to the specified hyperlink.

Abstract: The present invention provides software developers with the capability to create applications that can access information online and offline without having to program such capabilities into their applications. An application can gather information from various remote data sources via a network or other communication means, and still have access to all or a portion of that information when the computing device running the application is no longer connected to the network. In one embodiment, a client manages information access, caching and synchronization for the application. When connected, information accessed is stored in a local data store on (or near) the computing device. When disconnected, requests are run against the local data store instead of the remote data source. When reconnected, information is synchronized between the local data store and the remote data source.

Abstract: The present invention provides software developers with the capability to create applications that can access information online and offline without having to program such capabilities into their applications. An application can gather information from various remote data sources via a network or other communication means, and still have access to all or a portion of that information when the computing device running the application is no longer connected to the network. In one embodiment, a client manages information access, caching and synchronization for the application. When connected, information accessed is stored in a local data store on (or near) the computing device. When disconnected, requests are run against the local data store instead of the remote data source. When reconnected, information is synchronized between the local data store and the remote data source.

Abstract: A heart valve including a generally annular body and a disc within the body. A ring-like protuberance projects from one face of the disc, and a fulcrum member projecting into the central opening of the valve body engages the inner surface of the protuberance. The disc pivots about the fulcrum member, to open and close the valve, and fits loosely between the fulcrum member and retaining elements so that the disc can rotate in its own plane. The rig-like protuberance defines an abutment responsive to fluid flowing in the no-flow direction of the valve for aiding pivotal movement of the disc to close the valve. An upstanding continuous wall on the face of the disc opposite the protuberance responds to fluid flow in the flow direction of the valve for aiding the pivotal movement of the disc to open the valve. The fulcrum member carries a guide plate which cooperates with the free end of the fulcrum means for preventing movement of the disc in its own plane when the valve is closed.

Abstract: A heart valve including a generally annular body and a disc within the body pivotable about a centerline of the disc. Vanes project from one face of the disc in a direction opposite the flow direction through the valve, fluid flow against the vanes causing the valve to open. A baffle extends across the body adjacent the face of the disc opposite the face from which the vanes project, the baffle directing fluid flowing in the no-flow direction of the valve against the disc so as to close the valve. The disc portions on opposite sides of the pivot axis are of substantially equal size and weight. The disc is limited to pivoting through an acute angle, and in certain embodiments may also rotate in its own plane. The vanes may be arranged on only one half the disc, or symmetrically on the entire disc, and the vanes are preferably spaced apart to define openings between them to accommodate fluid flow. A second baffle may extend across the body adjacent the face of the disc from which the vanes project.