Abstract: Compositions and methods for treating striated muscle injury, treating striated muscle atrophy, and/or for promoting striated muscle growth are provided and include administering zinc oxide nanoparticles to a subject in need thereof. The zinc oxide nanoparticles can be adminstered before, during, and/or after exposure to an injurious stimuli, such as radiation. Administration of the zinc oxide nanoparticles reduces activation of autophagy regulators, increases striated muscle anabolism, increases DNA repair signaling, and/or increases striated muscle protein synthesis and growth.

Abstract: Compositions and methods for treating striated muscle injury, treating striated muscle atrophy, and/or for promoting straited muscle growth are provided and include administering zinc oxide nanoparticles to a subject in need thereof. The zinc oxide nanoparticles can be adminstered before, during, and/or after exposure to an injurious stimuli, such as radiation. Adminstration of the zinc oxide nanoparticles reduces activation of autophagy regulators, increases striated muscle anabolism, increases DNA repair signaling, and/or increases striated muscle protein synthesis and growth.

Abstract: Methods for treating sepsis are provided and include the administration an effective amount of cerium oxide nanoparticles to a subject in need thereof. The sepsis being treated can include polymicrobial sepsis and can include the administration of about 0.1 mg/kg to about 1.0 mg/kg of the cerium oxide nanoparticles. The administration of the cerium oxide nanoparticles further allows one or more of the symptoms of sepsis to be treated. Methods of treating an inflammatory disorder that make use of cerium oxide nanoparticles are further provided.

Abstract: The present disclosure provides a prefilled wrap, such as a prefilled poultice wrap, for applying to the body of a human or animal. The prefilled wrap includes a matrix defining a plurality of pockets therein. The prefilled wrap also includes a dry ingredient formulation contained in each of the plurality of pockets. The present disclosure also provides a prefilled wrap system for applying to the body of a human or animal. The prefilled wrap system includes an outer casing configured to wrap around a portion of the body of the human or animal. The prefilled wrap system also includes a prefilled wrap removably received in the outer casing. The outer casing is configured to hold the prefilled wrap against the body of the human or animal. Related methods of manufacturing the prefilled wrap, applying the prefilled wrap, and applying the prefilled wrap system are also disclosed.