Patents by Inventor Eric Bornstein
Eric Bornstein has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20120116484Abstract: Optical methods and devices are provided for the reduction of the lipid content of adipocytes without significant heat or intolerable adverse effect on the cells and their surrounding tissues. The optical method and device can be used to irradiate adipose tissue through the skin with non-thermal and non-destructive effects by application of near infrared (NIR) irradiation at selected wave bands in selected ranges to affect modulation of innate enzymatic processes involved in lipolysis, lipogenesis, leptin secretion, adiponectin secretion, and/or glucose absorption.Type: ApplicationFiled: July 13, 2011Publication date: May 10, 2012Inventor: Eric BORNSTEIN
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Publication number: 20110295343Abstract: Systems and methods are disclosed herein for applying near-infrared optical energies and dosimetries to alter the bioenergetic steady-state trans-membrane and mitochondrial potentials (??-steady) of all irradiated cells through an optical depolarization effect. This depolarization causes a concomitant decrease in the absolute value of the trans-membrane potentials ?? of the irradiated mitochondrial and plasma membranes. Many cellular anabolic reactions and drug-resistance mechanisms can be rendered less functional and/or mitigated by a decrease in a membrane potential ??, the affiliated weakening of the proton motive force ?p, and the associated lowered phosphorylation potential ?Gp. Within the area of irradiation exposure, the decrease in membrane potentials ?? will occur in bacterial, fungal and mammalian cells in unison. This membrane depolarization provides the ability to potentiate antimicrobial, antifungal and/or antineoplastic drugs against only targeted undesirable cells.Type: ApplicationFiled: October 29, 2009Publication date: December 1, 2011Inventors: Eric Bornstein, John Wlassich
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Publication number: 20110208274Abstract: A kit for treating an antimicrobial resistant biological contaminate at a treatment site is disclosed which includes a diffuser tip adapted to receive near infrared therapeutic light from a light delivery system and diffuse the light to illuminate at least a portion of the treatment site; a quantity of an antimicrobial; agent; instructions to use the antimicrobial agent in conjunction with the therapeutic light to potentiate the antimicrobial agent to treat the biological contaminate; and suitable packaging.Type: ApplicationFiled: March 20, 2009Publication date: August 25, 2011Inventor: Eric Bornstein
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Publication number: 20110082525Abstract: Methods, systems, and apparatus for Near Infrared Microbial Elimination Laser Systems (NIMELS) including use with medical devices are disclosed. The medical devices can be situated in vivo. Suitable medical devices include catheters, stents, artificial joints, and the like. NIMELS methods, systems, and apparatus can apply near infrared radiant energy of certain wavelengths and dosimetries capable of impairing biological contaminants without intolerable risks and/or adverse effects to biological moieties other than a targeted biological contaminant associated with traditional approaches described in the art (e.g., loss of viability, or thermolysis). Lasers including diode lasers may be used for one or more light sources. A delivery assembly can be used to deliver the optical radiation produced by the source(s) produced to an application region that can include patient tissue. Exemplary embodiments utilize light in a range of 850 nm-900 nm and/or 905 nm-945 nm at suitable NIMELS dosimetries.Type: ApplicationFiled: May 10, 2010Publication date: April 7, 2011Inventor: Eric Bornstein
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Publication number: 20110070552Abstract: Provided herein are methods and compositions useful for the treatment of periodontal disease exploiting optical and thermal emissions of near-infrared laser systems and fibers in order to target chromophore-stained biofilm while minimizing damage to healthy tissues.Type: ApplicationFiled: October 27, 2009Publication date: March 24, 2011Inventor: Eric Bornstein
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Publication number: 20090299263Abstract: Systems and methods are disclosed herein for applying near-infrared optical energies and dosimetries to alter the bioenergetic steady-state trans-membrane and mitochondrial potentials (??-steady) of all irradiated cells through an optical depolarization effect. This depolarization causes a concomitant decrease in the absolute value of the trans-membrane potentials ?? of the irradiated mitochondrial and plasma membranes. Many cellular anabolic reactions and drug-resistance mechanisms can be rendered less functional and/or mitigated by a decrease in a membrane potential ??, the affiliated weakening of the proton motive force ?p, and the associated lowered phosphorylation potential ?Gp. Within the area of irradiation exposure, the decrease in membrane potentials ?? will occur in bacterial, fungal and mammalian cells in unison. This membrane depolarization provides the ability to potentiate antimicrobial, antifungal and/or antineoplastic drugs against only targeted undesirable cells.Type: ApplicationFiled: October 31, 2007Publication date: December 3, 2009Applicant: Nomir Medical Technologies, Inc.Inventor: Eric Bornstein
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Publication number: 20090299441Abstract: Methods, systems, and apparatus for Near Infrared Microbial Elimination Laser Systems (NIMELS) including use with medical devices are disclosed. The medical devices can be situated in vivo. Suitable medical devices include catheters, stents, artificial joints, and the like. NIMELS methods, systems, and apparatus can apply near infrared radiant energy of certain wavelengths and dosimetries capable of impairing biological contaminants without intolerable risks and/or adverse effects to biological moieties other than a targeted biological contaminant associated with traditional approaches described in the art (e.g., loss of viability, or thermolysis). Lasers including diode lasers may be used for one or more light sources. A delivery assembly can be used to deliver the optical radiation produced by the source(s) produced to an application region that can include patient tissue. Exemplary embodiments utilize light in a range of 850 nm-900 nm and/or 905 nm-945 nm at suitable NIMELS dosimetries.Type: ApplicationFiled: October 31, 2007Publication date: December 3, 2009Applicant: Nomir Medical Technologies, Inc.Inventor: Eric Bornstein
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Patent number: 7621745Abstract: Provided herein are methods and compositions useful for the treatment of periodontal disease exploiting optical and thermal emissions of near-infrared laser systems and fibers in order to target chromophore-stained biofilm while minimizing damage to healthy tissues.Type: GrantFiled: October 8, 2004Date of Patent: November 24, 2009Assignee: Nomir Medical Technologies Inc.Inventor: Eric Bornstein
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Publication number: 20090118721Abstract: Methods, systems, and apparatus for Near Infrared Microbial Elimination laser Systems (NIMELS) are disclosed that can apply near infrared radiant energy of certain wavelengths and dosimetries capable of impairing biological contaminants, for example fungus, without intolerable risks and/or adverse effects to biological moieties other than a targeted biological contaminant. Lasers including diode lasers may be used as one or more light sources. A delivery assembly can be used to deliver the optical radiation produced by the source(s) produced to an application region that can include patient tissue. A flat top lens can be included to produce a flat top beam distribution. Exemplary embodiments utilize laser light in a near infrared range of 850 nm-900 nm and/or 905 nm-945 nm at suitable NIMELS dosimetries. For certain applications, laser light in two spectral ranges including 870 nm and 930 nm, respectively, can be utilized.Type: ApplicationFiled: July 21, 2006Publication date: May 7, 2009Inventor: Eric Bornstein
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Publication number: 20090105790Abstract: Methods, systems, and apparatus for Near Infrared Microbial Elimination Laser Systems (NIMELS) including use with medical devices are disclosed. The medical devices can be situated in vivo. Suitable medical devices include catheters, stents, artificial joints, and the like. NIMELS methods, systems, and apparatus can apply near infrared radiant energy of certain wavelengths and dosimetries capable of impairing biological contaminants without intolerable risks and/or adverse effects to biological moieties other than a targeted biological contaminant associated with traditional approaches described in the art (e.g., loss of viability, or thermolysis). Lasers including diode lasers may be used for one or more light sources. A delivery assembly can be used to deliver the optical radiation produced by the source(s) produced to an application region that can include patient tissue. Exemplary embodiments utilize light in a range of 850 nm-900 nm and/or 905 nm-945 nm at suitable NIMELS dosimetries.Type: ApplicationFiled: May 19, 2008Publication date: April 23, 2009Applicant: NOMIR MEDICAL TECHNOLOGIES, INC.Inventor: Eric Bornstein
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Publication number: 20090087816Abstract: Methods and devices for Live Biofilm Targeted Thermolysis (LBTT) are disclosed. The disclosed LBTT methods can be used for thermolysis and coagulation of the live periodontal Biofilm with incandescent light and a targeting agent as heat sink. A delivery assembly can be used to deliver the incandescent light generated through the secondary quantum optical and thermal emissions from a carbonized near infrared diode laser delivery fiber, otherwise known as a “hot tip,” to an application region that includes live biofilm. With this novel targeted approach of exploiting the incandescent hot tip's radiant energy (ie. its optical and thermal emissions), the physical nature of the targeted live biofilm in the periodontal pocket is changed from a mucinous liquid-gel, to a semi-solid coagulum, which then facilitates its removal from the effected pocket, with traditional mechanical SRP periodontal techniques.Type: ApplicationFiled: November 30, 2006Publication date: April 2, 2009Inventor: Eric Bornstein
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Patent number: 7470124Abstract: A system and process for thermolytic eradication of bacteria and biofilm in the root canal of a human tooth involve an elongated and flexible optical probe and a laser oscillator that provides the probe with low infrared energy. The optical probe is sufficiently long for insertion into substantially the entire length of the root canal of the tooth. The optical probe causes lateral dispersion of the radiation from the probe throughout the root canal. The radiation is provided at an energy density and for a period of time that are necessary to selectively target bacteria and live biofilm in the dentinal tubules of an entire root canal system, at once, thereby (1) inhibiting creation of a blackbody “hot tip”, and (2) inducing laser interstitial thermotherapy (LITT) within the root-canal space.Type: GrantFiled: April 9, 2004Date of Patent: December 30, 2008Assignee: Nomir Medical Technologies, Inc.Inventor: Eric Bornstein
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Publication number: 20080267814Abstract: Methods, systems, and apparatus for Near Infrared Microbial Elimination Laser Systems (NIMELS) including use with medical devices are disclosed. The medical devices can be situated in vivo. Suitable medical devices include catheters, stents, artificial joints, and the like. NIMELS methods, systems, and apparatus can apply near infrared radiant energy of certain wavelengths and dosimetries capable of impairing biological contaminants without intolerable risks and/or adverse effects to biological moieties other than a targeted biological contaminant associated with traditional approaches described in the art (e.g., loss of viability, or thermolysis). Lasers including diode lasers may be used for one or more light sources. A delivery assembly can be used to deliver the optical radiation produced by the source(s) produced to an application region that can include patient tissue. Exemplary embodiments utilize light in a range of 850 nm-900 nm and/or 905 nm-945 nm at suitable NIMELS dosimetries.Type: ApplicationFiled: August 3, 2006Publication date: October 30, 2008Inventor: Eric Bornstein
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Publication number: 20080159345Abstract: A dual wavelength laser in the low infrared electromagnetic spectrum is disclosed for destruction of bacteria via photo-damage optical interactions through direct selective absorption of optical energy by intracellular bacterial chromophores. The dual wavelength (NIMELS) laser includes an optical assembly and all associated components necessary for the housing of two distinct diode laser arrays (870 nm diode array and 930 nm diode array) that can be emitted through an output connector and wavelength multiplexer as necessary. With this preferred design, the dual wavelengths (870 nm and 930 nm) can be emitted singly, or multiplexed together to be conducted along a common optical pathway, or multiple optical pathways, to achieve maximal bacterial elimination.Type: ApplicationFiled: January 24, 2008Publication date: July 3, 2008Applicant: Nomir Medical Technologies, Inc.Inventor: Eric Bornstein
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Publication number: 20080139992Abstract: Systems and methods are disclosed herein for applying near-infrared optical energies and dosimetries to alter the bioenergetic steady-state trans-membrane and mitochondrial potentials (??-steady) of all irradiated cells through an optical depolarization effect. This depolarization causes a concomitant decrease in the absolute value of the trans-membrane potentials ?? of the irradiated mitochondrial and plasma membranes. Many cellular anabolic reactions and drug-resistance mechanisms can be rendered less functional and/or mitigated by a decrease in a membrane potential ??, the affiliated weakening of the proton motive force ?p, and the associated lowered phosphorylation potential ?Gp. Within the area of irradiation exposure, the decrease in membrane potentials ?? will occur in bacterial, fungal and mammalian cells in unison. This membrane depolarization provides the ability to potentiate antimicrobial, antifungal and/or antineoplastic drugs against only targeted undesirable cells.Type: ApplicationFiled: October 31, 2007Publication date: June 12, 2008Applicant: Nomir Medical Technologies, Inc.Inventor: Eric Bornstein
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Publication number: 20080138772Abstract: Systems, processes, techniques, and apparatus are described for thermolytic eradication of bacteria and biofilm in the root canal of a human tooth involve an elongated and flexible optical probe and a laser oscillator that provides the probe with near infrared energy. The optical probe can be sufficiently long for insertion into substantially the entire length of the root canal of the tooth. The optical probe causes lateral dispersion of the radiation from the probe throughout the root canal. The radiation is provided at an energy density and for a period of time that are necessary to selectively target bacteria and live biofilm in the dentinal tubules of an entire root canal system, at once, thereby (1) inhibiting creation of a blackbody “hot tip”, and (2) inducing laser interstitial thermotherapy (LITT) within the root-canal space. Near infrared wavelengths from about 700 nm through about 1100 nm can be used.Type: ApplicationFiled: August 20, 2007Publication date: June 12, 2008Inventor: Eric Bornstein
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Publication number: 20080131968Abstract: Systems and methods are disclosed herein for applying near-infrared optical energies and dosimetries to alter the bioenergetic steady-state trans-membrane and mitochondrial potentials (??-steady) of all irradiated cells through an optical depolarization effect. This depolarization causes a concomitant decrease in the absolute value of the trans-membrane potentials ?? of the irradiated mitochondrial and plasma membranes. Many cellular anabolic reactions and drug-resistance mechanisms can be rendered less functional and/or mitigated by a decrease in a membrane potential ??, the affiliated weakening of the proton motive force ?p, and the associated lowered phosphorylation potential ?Gp. Within the area of irradiation exposure, the decrease in membrane potentials ?? will occur in bacterial, fungal and mammalian cells in unison. This membrane depolarization provides the ability to potentiate antimicrobial, antifungal and/or antineoplastic drugs against only targeted undesirable cells.Type: ApplicationFiled: October 31, 2007Publication date: June 5, 2008Applicant: Nomir Medical Technologies, Inc.Inventor: Eric Bornstein
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Publication number: 20080077204Abstract: Optical therapeutic treatment devices, systems, apparatus, methods, and techniques are disclosed. Embodiments can include a housing extending along a central axis X, an elongated fiber guide coupled to the housing and adapted to receive an optical fiber having a proximal end and a distal end, a reflector assembly within the housing and extending along the central axis X. The distal end of the optical fiber can includes a carbonized tip within the reflector assembly. The reflector assembly is adapted to reflect the optical energy emitted from the distal end and propagating radially with respect to the central is, so that the reflected optical energy propagates at least in part along a propagation axis parallel to the central axis. Embodiments can utilize free space optics/transmission. Further embodiments can utilize NIR radiation (e.g., including 870 and 930 nm) that is suitable to cause free radical formation in microbes.Type: ApplicationFiled: July 24, 2007Publication date: March 27, 2008Applicant: Nomir Medical Technologies, Inc.Inventor: Eric Bornstein
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Publication number: 20080058908Abstract: Provided herein are methods and compositions useful for the treatment of periodontal disease exploiting optical and thermal emissions of near-infrared laser systems and fibers in order to target chromophore-stained biofilm while minimizing damage to healthy tissues.Type: ApplicationFiled: October 8, 2004Publication date: March 6, 2008Inventor: Eric Bornstein
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Publication number: 20080021370Abstract: Dual wavelength laser energy in the near infrared electromagnetic spectrum is described as destroying bacteria via photo-damage optical interactions through direct selective absorption of optical energy by intracellular bacterial chromophores. Use of various dual wave length laser systems include use of optical assembly including two distinct diode laser ranges (including 870 nm and 930 nm) that can be emitted to achieve maximal bacterial elimination without intolerable heat deposition. Related processes for medical procedures are also described.Type: ApplicationFiled: August 31, 2007Publication date: January 24, 2008Applicant: Nomir Medical Technologies, Inc.Inventor: Eric Bornstein