Abstract: The present invention is directed to a method for selecting or identifying a compound capable of modulating the activity of an ion-channels receptor, such as GABA receptor, by measuring the calcium influx via the P2X receptor in presence of its agonist ATP when coupled to said ion-channels receptor in recombinant cells coexpressing these two receptors. The invention also concerns a kit or a device comprising the essentiel elements to perform the method according to the invention. Finally, the present invention is directed to the use of said selected compounds for the prevention or the treatment of diseases related to said ion-channels receptor dysfunction.

Abstract: The invention features a hinge or coupling two panels (P1, P2), one of which at least opens rotatably about an axis (X) parallel to the planes of the said panels, comprising a mobile fixing element (1) on the opening panel, a fixing element on the other panel and linking means (3) between the fixing elements co-operating with elastic return means of the panel opening to at least a stable angular equilibrium position, characterized in that the said return means consists of a ring (4) located in a cavity (10) of the mobile fixing element (1) and capable of being elastically deformed by the pressing action of a cam (30) rotating about a central shaft (5) parallel to the planes of the panels, being carried by the linking means (3).