Patents by Inventor Eric Brian Kmiec

Eric Brian Kmiec has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Compositions and methods for improving homogeneity of DNA generated using a CRISPR/Cas9 cleavage system
    Patent number: 11441146
    Abstract: The invention relates to the unexpected discovery of a system and methods for precise homology directed repair after CRISPR/Cas9 cleavage. The invention includes a DNA cleavage and repair system comprising a CRISPR/Cas9 system and an oligonucleotide 100% complementary to cleaved DNA to promote homology directed DNA repair. The invention further includes methods for inducing homology directed repair of cleaved DNA and repairing a CRISPR/Cas9 cleavage.
    Type: Grant
    Filed: January 10, 2017
    Date of Patent: September 13, 2022
    Assignee: Christiana Care Health Services, Inc.
    Inventors: Eric Brian Kmiec, Pawel Alexander Bialk
  • Compositions and Methods for Improving Homogeneity of DNA Generated Using a CRISPR/Cas9 Cleavage System
    Publication number: 20170198277
    Abstract: The invention relates to the unexpected discovery of a system and methods for precise homology directed repair after CRISPR/Cas9 cleavage. The invention includes a DNA cleavage and repair system comprising a CRISPR/Cas9 system and an oligonucleotide 100% complementary to cleaved DNA to promote homology directed DNA repair. The invention further includes methods for inducing homology directed repair of cleaved DNA and repairing a CRISPR/Cas9 cleavage.
    Type: Application
    Filed: January 10, 2017
    Publication date: July 13, 2017
    Inventors: Eric Brian Kmiec, Pawel Alexander Bialk