Abstract: Provided herein are methods and compositions for modulating a microorganism's response to an antimicrobial agent. In one embodiment, the method comprises contacting the microorganism with an antimicrobial agent and bicarbonate. In one embodiment, provided herein are methods for treating a microbial infection comprising administering to a subject in need an effective amount of (i) bicarbonate and (ii) an antimicrobial agent. Also provided herein are methods of screening for antimicrobial compounds.

Abstract: A method includes receiving, by a user device, a prompt associated with treatment of a patient. The method includes determining a treatment context for the treatment of the patient based on access to a back-end treatment context support system. The method includes processing the prompt in view of the treatment context using one or more trained machine learning models to generate one or more actionable recommendations. The method includes outputting the one or more actionable recommendations via at least one of the user device or an additional device associated with the user device.

Abstract: In embodiments, a system comprises a server computing device comprising a messaging platform configured to provide messaging between a plurality of different types of medical applications, a first computing device of a doctor and a second computing device of a patient or prospective patient. The first computing device comprises a doctor-focused medical application and a first chat module that integrates with the doctor-focused medical application and that enables the doctor-focused medical application to interface with the messaging platform. The second computing device comprises a patient-focused medical application and a second chat module that integrates with the patient-focused medical application and that enables the patient-focused medical application to interface with the messaging platform, wherein the patient-focused medical application has different functionality than the doctor-focused medical application.

Abstract: A ligation clip loading device includes a cannula including a cannula body and an instrument lumen extending through a longitudinal axis of the cannula body, and a stack of ligation clips axially arranged about the instrument lumen. The ligation clips are accessible through a series of slots allowing for loading of an endoscopic clip applier with the ligation clips within a body cavity, such as an intra-abdominal cavity.

Abstract: A computer-implemented method for dynamic, data-driven consolidation of user interface interactions requesting roadside assistance. The method includes identifying a data objective requiring user data, accessing user data, and determining whether the user data satisfies a confidence threshold. Based at least in part on the confidence threshold determination, one of a first data objective representation and a second data objective representation is displayed. A request for roadside assistance—following satisfaction of the confidence threshold—is also issued.

Abstract: A nozzle for a liquid-cooled plasma arc torch is provided. The nozzle includes an inner nozzle body defining a proximal end and a distal end extending along a central longitudinal axis of the nozzle. The inner nozzle body comprises a plasma bore disposed along the central longitudinal axis. An outer nozzle body is disposed about the inner nozzle body. The outer nozzle body and the inner nozzle body are joined at a distal interface to form a circumferential fluid seal. A liquid coolant channel defined between the inner nozzle body and the outer nozzle body. The liquid coolant channel is disposed substantially circumferentially into the inner nozzle body. A distal tip portion of the liquid coolant channel is located in the inner nozzle body between the distal interface and the plasma bore along a radial axis that is substantially perpendicular to the central longitudinal axis.

Abstract: The present invention discloses novel pentamidine analogues such as pentamidine analogs having the general formula: wherein: X is C, N, or —CH—CH—, Y is Y1 when X is N, and Y is Y1 and Y2 when X is C, or —CH—CH—, Y1, or Y1 and Y2 independently, are selected from H, hydroxyl, lower alkyl, lower alkoxy, halogen, nitro, amino, cyano or thiol, wherein the lower alkyl or alkoxy is optionally substituted with one or more of hydroxyl, halogen, nitro, amino, cyano, thiol, or a 5- or 6-membered aromatic or non-aromatic ring, optionally substituted with one or more of hydroxyl, lower alkyl, lower alkoxy, halogen, nitro, amino, cyano or thiol, wherein Y1 is not H when X is N; or Y1 is a 5- or 6-membered aromatic or non-aromatic ring, optionally substituted with one or more groups selected from hydroxyl, lower alkyl, lower alkoxy, halogen, nitro, amino, cyano, carboxy, or thiol, and Y2 is H, if present; or Y1 and Y2 together with X form a 5- to 8-membered hydrocarbon ring, optionally substituted with one or more g

Abstract: A gas supply system for a plasma cutting system is provided. The gas supply system includes a gas supply line configured to fluidly connect between a gas source and a plasma arc torch. The gas supply line is configured to receive a gas flow from the gas source for delivery to the plasma arc torch. The gas supply system also includes an oscillatory energy source disposed on the gas supply line and a gas flow sensor disposed on the gas supply line downstream of the oscillatory energy source. The gas supply system further includes a resonation chamber fluidly connected to the gas supply line between the oscillatory energy source and the gas flow sensor. The resonation chamber is configured to dampen an oscillation in the gas flow in the gas supply line.

Abstract: Compounds as exemplified by compound A are useful in the treatment of arenavirus infections and viral infections mediated by arenavirus glycoproteins.

Abstract: A system for instructing a user on repairing a vehicle configured to (i) receive, from the user computing device, a request to repair a vehicle, the vehicle including a damaged portion, (ii) prompt the user by displaying a prompt on a user interface of the user computing device to transmit one or more images of the damaged portion of the vehicle; (iii) execute a machine learning model by inputting the one or more images of the damaged portion of the vehicle, the machine learning model configured to determine damage to the vehicle based on at least the one or more images of the vehicle and to determine one or more repair facilities capable of performing repairs to the damage to the vehicle; and (iv) cause the one or more repair facilities to be displayed on the user computing device.

Abstract: The present disclosure is generally directed to antigen-binding domains that specifically bind to human transferrin receptor (TfR) and their use in transport across the blood brain barrier (BBB).

Abstract: The present disclosure is generally directed to antigen-binding domains that specifically bind to human CD98 heavy chain (CD98hc) and their use in transport across the blood brain barrier (BBB).

Abstract: Polymeric ligation clips and a clip applier for applying a polymeric ligation clip to tissue are disclosed herein. More particularly, the polymeric ligation clips include separate first and second beams that can be coupled to each other and are movable from a reduced diameter open position in which minimal strain is placed on the ligation clip to a clamped position and to a clip applier for delivering such a ligation clip to a surgical site.

Abstract: A system for instructing a user on repairing a vehicle configured to (i) receive, from the user, a request to repair a vehicle, including information about the vehicle; (ii) present, to the user via a user computer device, a user interface to allow the user to search for a repair facility to repair the vehicle; (iii) receive, from the user via the user interface, a selection of a repair facility; (iv) determine whether the selected repair facility is a select service location, where a select service location is a pre-authorized repair facility; and (v) if the selected repair facility is a select service location, transfer the information about the vehicle to a computer device associated with the selected repair facility.

Abstract: The present disclosure is generally directed to compositions that include antibodies, e.g., monoclonal antibodies, antibody fragments, etc., that specifically bind a TMEM106B polypeptide, e.g., a mammalian TMEM106B or human TMEM106B, and use of such compositions in preventing, reducing risk, or treating an individual in need thereof.

Abstract: Polymeric ligation clips and a clip applier for applying a polymeric ligation clip to tissue are disclosed herein. More particularly, the polymeric ligation clips include separate first and second beams that can be coupled to each other and are movable from a reduced diameter open position in which minimal strain is placed on the ligation clip to a clamped position and to a clip applier for delivering such a ligation clip to a surgical site.

Abstract: A quantum element (QE) at a network node stores a first quantum state constituent (QSC) of an entangled quantum state characterized by a non-factorable quantum relationship among QSCs comprising the first QSC and a second QSC stored at another QE at another network node. Managing one or more quantum error management (QEM) operations includes: (1) providing a schedule for the QEM operations that is based at least in part on at least a portion of a time over which the first QSC is stored at the first QE and an estimated fidelity of the entangled quantum state after at least one of the QEM operations, or (2) providing a type of one or more QEM operations selected from two or more different types based at least in part on a number of resource quantum elements available at the first node after the first QSC is stored at the first QE.

Abstract: Compounds of structural Formula I were developed for the treatment of infections by filoviruses including Ebolavirus and Marburgvirus, wherein, R1, R2, R3, X and Y are defined in the specification.

Abstract: A surgical access assembly includes a housing, a tubular member, and a valve assembly. The tubular member extends from the housing. The valve assembly is positioned in the housing and includes a centering mechanism, a guard assembly disposed on a first side of the centering mechanism, and an instrument seal disposed on a second side of the centering mechanism. The instrument seal including petals that are arrange in an overlapping arrangement.

Abstract: A surgical access assembly includes a cannula, a valve housing attached to the cannula, and a valve assembly positioned in the valve housing. The valve assembly includes a centering mechanism with a hoop and fingers, a ring with a flange at one end of the ring, a retainer having first and second discs, a guard having a frame and flaps attached to the frame, and a seal with petals attached to a support. The guard is at least partially disposed in the first disc and the seal is at least partially disposed in the second disc.