Patents by Inventor Eric C. Hsu

Eric C. Hsu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 9404088
    Abstract: The present invention provides chitosan-based nanoparticles that can protect nucleic acids and deliver the same into gut mucosal cells. Compositions and methods for the expression of therapeutic nucleic acids in cells of the gut mucosa are provided. Compositions and methods for delivering therapeutic proteins systemically from cells of the gut mucosa are also provided.
    Type: Grant
    Filed: March 24, 2011
    Date of Patent: August 2, 2016
    Assignee: ENGENE, INC.
    Inventors: Anthony T. Cheung, Eric C. Hsu
  • Patent number: 8846102
    Abstract: The present invention provides chitosan-based nanoparticles that can protect nucleic acids and deliver the same into gut mucosal cells. Compositions and methods for the expression of therapeutic nucleic acids in cells of the gut mucosa are provided. Compositions and methods for delivering therapeutic proteins systemically from cells of the gut mucosa are also provided.
    Type: Grant
    Filed: March 30, 2007
    Date of Patent: September 30, 2014
    Assignee: enGene, Inc.
    Inventors: Anthony T. Cheung, Eric C. Hsu
  • Publication number: 20110171276
    Abstract: The present invention provides chitosan-based nanoparticles that can protect nucleic acids and deliver the same into gut mucosal cells. Compositions and methods for the expression of therapeutic nucleic acids in cells of the gut mucosa are provided. Compositions and methods for delivering therapeutic proteins systemically from cells of the gut mucosa are also provided.
    Type: Application
    Filed: March 24, 2011
    Publication date: July 14, 2011
    Applicant: enGene, Inc.
    Inventors: Anthony T. Cheung, Eric C. Hsu
  • Publication number: 20110171314
    Abstract: The present invention provides chitosan-based nanoparticles that can protect nucleic acids and deliver the same into gut mucosal cells. Compositions and methods for the expression of therapeutic nucleic acids in cells of the gut mucosa are provided. Compositions and methods for delivering therapeutic proteins systemically from cells of the gut mucosa are also provided.
    Type: Application
    Filed: March 30, 2007
    Publication date: July 14, 2011
    Inventors: Anthony T. CHEUNG, Eric C. Hsu
  • Publication number: 20110039917
    Abstract: The invention provides highly concentrated chitosan-nucleic acid polyplex compositions and dispersions, and methods for producing the compositions and dispersions. Methods of mixing the chitosan-nucleic acid polyplexes include an inline mixing of chitosan solution and nucleic acid solution, followed by further concentrating the dispersion of chitosan-nucleic acid polyplexes, optionally with an aggregation inhibitor. Further provided are methods for altering the diameter of chitosan-nucleic acid polyplexes.
    Type: Application
    Filed: September 26, 2008
    Publication date: February 17, 2011
    Inventors: Eric C Hsu, Carlos Fleet, Anthony Cheung, Jun Gao
  • Publication number: 20090041740
    Abstract: The invention provides compositions and methods for inhibiting the growth or proliferation of hyperproliferative cells or inducing regression of hyperproliferative cells. More specifically, the invention provides compositions and methods for stimulating glycogen accumulation in target cells (e.g., hyperproliferative cells) in order to increase glycogen to a level that is toxic to the target cell.
    Type: Application
    Filed: January 22, 2008
    Publication date: February 12, 2009
    Applicant: enGene, Inc.
    Inventors: SCOTT POWNALL, Anthony T. Cheung, Eric C. Hsu, Bruno Doiron
  • Publication number: 20040043949
    Abstract: The invention provides anti-pathogen polypeptide and polynucleotide compositions, and methods of use. In general, the composition of the invention provide a modified pro-polypeptide comprising a pro-domain, a pathogen protease cleavage site, and a cytotoxic domain which can be activated by cleavage of the pro-polypeptide by a protease of an intracellular pathogen. The invention further provides nucleic acids encoding the subject polypeptides, and vectors and host cells comprising the subject nucleic acids. Cleavage of the pro-polypeptide by the pathogen protease results in activation of the cytotoxic domain, and decreases the viability of the pathogen-infected host cell. Methods for using the subject nucleic acids and polypeptides to reduce the viability of a pathogen-infected cell, and for reducing the pathogen load of a subject infected with a pathogen are provided. The invention further provides kits for carrying out the subject methods.
    Type: Application
    Filed: August 30, 2002
    Publication date: March 4, 2004
    Inventors: Christopher Richardson, Eric C. Hsu, David Lorne Tyrrell, Norman M. Kneteman