Abstract: A permeation enhancer composition is provided for increasing the permeability of skin or mucosal tissue to topically or transdermally administered pharmacologically or cosmeceutically active agents. The composition is comprised of a hydroxide-releasing agent and a lipophilic co-enhancer such as a fatty alcohol, a fatty ether, or a fatty acid ester, including fatty acid esters of polyols such as propylene glycol and glycerol. Also provided are pharmaceutical formulations containing a therapeutically effective amount of an active agent in addition to the aforementioned enhancer composition, methods for administering active agents topically or transdermally with enhanced permeation, and drug delivery systems for application to an individual's skin or mucosal tissue, wherein the systems are formulated so as to contain an active agent to be administered and an effective permeation enhancing amount of an enhancer composition of the invention.

Abstract: A method is provided for increasing the permeability of skin or mucosal tissue to topically or transdermally administered pharmacologically or cosmeceutically active agents. The method involves use of a specified amount of a hydroxide-releasing agent, the amount optimized to increase the flux of the active agent through a body surface while minimizing the likelihood of skin damage, irritation or sensitization. Topically applied formulations and drug delivery devices employing hydroxide-releasing agents as permeation enhancers are provided as well.

Abstract: A stick-on audio microchip recorder/playback product for message conveyance-, audio mail-, product promotion and self-reminder purposes. The product enables a user to record a personal (or business-oriented) message or self-reminder, and non-permanently fasten the recorder upon surfaces such as household doors, walls, mirrors; compatible (carry-able) objects such as appointment books or notebooks; or upon interiors of mailing-, packaging- or shipping vessels, in desired temporary locations where the intended recipient would be most likely to encounter it. The recorder is easily removable by the end-user, and reusable. A microchip recording/playback circuit, microphone, speaker, battery and record/playback controls, are secured in a housing. Preferably, the housing has on its underside an attached stick-on fastener, including a stack of "pressure sensitive" peel-off adhesive stickers, each having on their undersurface a medium adhesion substance.

Abstract: An "audio mailer," including a tape recorder or other sound recording and reproducing device non-removably encased and configured as a mailer, so that a user can conveniently and confidentially send or receive voice or other sound messages through the mail. The mailer may further have a crevice space for an inserted enclosure, such as a letter, document, photograph or other indicia. A customized or commercially available small tape recorder and audiotape sound storage medium may be employed in the preferred embodiment. The audiotape may be either built-in or contained in a removable microcassette. Duplicate removable audiotape microcassettes may be employed to enable a sender to simultaneously record a copy of a mailed audio message and preserve it for future reference. In an alternate embodiment, computer microchip-based sound recording and reproducing technology and storage medium may be employed.