Abstract: Systems and methods are described for monitoring, treating, and preventing a pain state of an individual. In an aspect, a system includes, but is not limited to, a deformable substrate; a sensor assembly coupled to the deformable substrate, the sensor assembly including a motion sensor and a physiological sensor, the sensor assembly configured to generate one or more sense signals based on detection of a movement of the body portion by the motion sensor and a physiological parameter of the body portion by the physiological sensor; a processor including circuitry configured to identify a physiological state of the individual subject based on at least one of the movement of the body portion or the physiological parameter; and an effector operably coupled to the processor and configured to affect the body portion responsive to control by the processor.

Abstract: Methods, computer program products, and systems are described that include accepting an indication of a schedule for administration of a bioactive agent to an individual and presenting an indication of an artificial sensory experience at least partly based on the accepting an indication of the schedule for administration of the bioactive agent to the individual.

Abstract: Treatment of cardiac tissue via an implantable heart treatment device is described. A device embodiment includes, but is not limited to, a substrate; an electromagnetic signal generator configured to generate one or more electric signals configured to stimulate one or more tissues of a heart; a metabolic molecule supply device configured to supply one or more metabolic molecules to one or more tissues of the heart; and control circuitry operably coupled to the electromagnetic signal generator and the metabolic molecule supply device, the control circuitry configured to generate one or more control signals according to at least a first control protocol and a second control protocol, dependent upon a status of a ventricular fibrillation event of the heart.

Abstract: Treatment of cardiac tissue via an implantable heart treatment device is described. A device embodiment includes, but is not limited to, a substrate configured for implantation within a body; an electromagnetic signal generator coupled to the substrate and configured to generate one or more electric signals configured to stimulate one or more tissues of a heart; and an oxygenator coupled to the substrate and configured to supply one or more oxygenated molecules to one or more tissues of the heart, the oxygenator including a blood inlet portion, a blood outlet portion, and an oxygen exchange portion positioned between the blood inlet portion and the blood outlet portion, the oxygen exchange portion including a high surface area oxygen exchanger configured to transfer one or more oxygenated molecules from the high surface area oxygen exchanger to blood passing from the blood inlet portion to the blood outlet portion.

Abstract: Treatment of cardiac tissue via an implantable heart treatment device is described. A device embodiment includes, but is not limited to, a substrate configured for implantation within a body; an electromagnetic signal generator coupled to the substrate and configured to generate one or more electric signals configured to stimulate one or more tissues of a heart within the body; and an energy-carrier molecule delivery device coupled to the substrate and configured to supply one or more non-oxygen cellular energy sources to one or more tissues of the heart within the body.

Abstract: Methods, devices, systems, and apparatus, including computer programs encoded on a computer storage medium, for brain-controlled body movement assistance devices. In one aspect, a device includes a brain-controlled body movement assistance device with a brain-computer interface (BCI) component adapted to be mounted to a user, a body movement assistance component operably connected to the BCI component and adapted to be worn by the user, and a feedback mechanism provided in connection with at least one of the BCI component and the body movement assistance component, the feedback mechanism being configured to output information relating to a usage session of the brain-controlled body movement assistance device.

Abstract: Users of brain-computer interface (BCI) systems wear an electroencephalography (EEG) headset that places multiple electrodes in contact with the scalp of the user. The EEG headsets provided herein provide user convenience and EEG accuracy. For example, the positioning of the EEG electrodes is readily adjustable to provide a customizable fit with various head shapes and sizes, and to conveniently provide repeatable electrode-to-scalp contact. Further, EEG accuracy is improved by integrating electromagnetic shielding into the EEG headset to reduce electromagnetic interference.

Abstract: Systems and related methods for controlling an ear stimulation device with a personal computing device, based on analysis of an image of a user of the personal computing device captured with a camera associated with the personal computing device, are described. One or more parameter is determined from the processed image, including, but not limited, to user identity, emotion, physiological condition, or placement of a stimulator earpiece, and control of the ear stimulation device is based thereon. If the earpiece is located incorrectly, in an aspect, delivery of a stimulus is prevented. In another aspect, the user is notified of the need to reposition an incorrectly located earpiece.

Abstract: Systems and related methods for controlling an ear stimulation device with a personal computing device are described. Multiple factors, including a mood of the user, a user control input, and a secondary factor input are used in controlling the ear stimulation device. Secondary factors include, a variety of factors relating to or influencing the state of the user, including but not limited to, environmental conditions, sleep, diet, or various activities of the user. User inputs can be open-ended or selected from a menu, for example. In an aspect, a correlation module correlates mood of the user to other factors, and control of stimulation is based thereon. In various aspects, the system is also responsive to inputs from sensors or computing networks. In an aspect, the earpiece delivers an audio output such as music from an audio player.

Abstract: A method for scanning an individual with a security device includes providing a scanner, engaging the scanner in a first scanning mode to produce an initial scan of the individual with a controller, producing an initial representation based on the initial scan, determining a property of a second scanning mode based on information from the initial representation, and engaging the scanner in the second scanning mode to produce a second scan of the individual.

Abstract: System and methods are described herein for generating an injection guide, which include receiving one or more digital images of a body region of an individual, the body region including one or more physical registration landmarks, generating at least one digital representation of the body region using the one or more digital images, the at least one digital representation including one or more digital registration landmarks corresponding to the one or more physical registration landmarks on the body region, adding one or more digitally registered injection sites to the at least one digital representation of the body region in an injection-treatment pattern, the one or more digitally registered injection sites registered relative to the one or more digital registration landmarks, and generating one or more output signals having information for controlling one or more controllable light-emitting elements to illuminate a location on a surface of the body region of the individual corresponding in location to at

Abstract: A system for utilizing power extracted from intraluminal pressure changes may comprise: (a) an intraluminal generator; (b) an intraluminal pressure change-receiving structure operably coupled to the intraluminal generator; and (c) a power utilization device. A system for utilizing power extracted from intraluminal pressure changes may comprise: (a) means for receiving an intraluminal pressure change; (b) means for converting an intraluminal pressure change into energy with an intraluminal generator; and (c) means for providing, the energy to a power utilization device.

Abstract: A computationally implemented method includes, but is not limited to: detecting one or more occurrences of one or more specific patterns of usage of one or more non-communication (NC) productivity applications by one or more end users; and providing to the one or more end users, in response to said detecting, access to one or more particular messages through one or more channels of one or more NC productivity application interfaces, the one or more NC productivity application interfaces for accessing the one or more NC productivity applications by the one or more end users. In addition to the foregoing, other method aspects are described in the claims, drawings, and text forming a part of the present disclosure.

Abstract: Methods, computer program products, and systems are described that include measuring at least one effect of a combined bioactive agent and artificial sensory experience on an individual and/or modifying at least one of the bioactive agent or the artificial sensory experience at least partially based on the at least one effect.

Abstract: Devices and methods for profiling microbiota of skin are described which include a hand-held microbe profiling device including a housing defining an opening, the housing including at least one rotatable component at least partially disposed in the opening defined by the housing, an elongated flexible strip disposed on an outer surface of the at least one rotatable component, the outer surface of the elongated flexible strip positioned to contact one or more regions of a skin surface of an individual through the opening defined by the housing, a location-capture component to detect a location of one or more regions of the skin surface as the elongated flexible strip contacts said one or more regions, at least one sensor component to detect one or more signals emitted or reflected from the elongated flexible strip, and a computing component to associate the location of said one or more regions of the skin surface and the detected one or more signals.

Abstract: Devices, compositions, and methods are described which provide a tubular nanostructure or a composite tubular nanostructure targeted to a lipid bilayer membrane. The tubular nanostructure includes a hydrophobic surface region flanked by two hydrophilic surface regions. The tubular nanostructure is configured to interact with a lipid bilayer membrane and form a pore in the lipid bilayer membrane. The tubular nanostructure may be targeted by including at least one ligand configured to bind to one or more cognates on the lipid bilayer membrane of a target cell.

Abstract: Devices and systems for sampling and profiling microbiota of skin are described which include a replaceable microbe sampling unit including a substrate and a location information storage component, the substrate including a microbe-capture region configured to capture at least one type of microbe from one or more regions of a skin surface of an individual, and the location information storage component configured to store information associated with the location of said one or more regions of the skin surface of the individual.

Abstract: Compositions and methods are described herein for treating a bone disorder, including a bone-targeting complex including at least a portion of a nitric oxide synthase; a bone-targeting agent; and a linker coupling the at least a portion of the nitric oxide synthase to the bone-targeting agent.

Abstract: Compositions and methods are described herein for treating a bone disorder, including a bone-targeting complex including an activator of nitric oxide synthase; a bone-targeting agent; and a linker coupling the activator of nitric oxide synthase to the bone-targeting agent.

Abstract: Compositions and methods are described herein for treating a bone disorder, including a bone-targeting complex including an inhibitor of nitric oxide synthase uncoupling; a bone-targeting agent; and a linker coupling the inhibitor of nitric oxide synthase uncoupling to the bone-targeting agent.