Abstract: A device is provided for overcoming freezing of gait. Suitably, the device includes a sleeve sized and shaped to be worn on a leg of a human subject, an array of electrodes carried by the sleeve and positioned to make surface contact with a skin of the leg when the sleeve is worn on by the human subject, and a controller in communication with the array of electrodes. The controller is operative to receive muscle activity data from the array of electrodes indicative of muscle activity in the leg, identify an onset of a freezing of gait episode based on the received muscle activity data, and trigger energization of one or more targeted electrodes in response to identification of the onset of the freezing of gait episode to mitigate against the freezing of gait episode.

Abstract: In a method of neurological assessment, multichannel electromyography (EMG) data are acquired for an anatomical region. A pairwise EMG channel-EMG channel similarity matrix is generated from the acquired multichannel EMG data. Network analysis is performed on the similarity matrix to generate a network representing the similarity matrix. One or more metrics of the network are computed. One or more biomarkers are determined for the anatomical region based on the one or more metrics. In another method, EMG data are acquired using an electrode array contacting skin of a target anatomy, the EMG data are processed to produce reduced-dimensionality data; and time-invariant muscle synergies and corresponding time-varying activation functions are determined in the reduced-dimensionality data.

Abstract: A method of treating spasticity uses a garment worn on a target anatomy so as to arrange electrodes on an inner surface of the garment contacting the skin of the target anatomy. Using an electronic processor, a spasticity treatment cycle is performed. The spasticity treatment cycle is initiated by providing a human-perceptible prompt to initiate a spastic event, or by triggering the spastic event by applying electrical stimulation to at least a portion of the target anatomy using the electrodes. Thereafter, electromyography (EMG) signals are measured from the target anatomy using the electrodes. One or more spasm regions in the target anatomy are identified based on the EMG signals. Targeted treatment of the one or more spasm regions is performed using neuromuscular electrical stimulation (NMES), or is directed to be performed by displaying a representation of the target anatomy with the one or more spasm regions indicated on the representation.

Abstract: In a method of performing spinal reflex conditioning for an anatomical limb of a person, a spinal reflex is evoked by electrically stimulating a peripheral nerve of the anatomical limb, for example using stimulation electrodes disposed on an armband or leg band. The resulting spinal reflex is measured using electromyography (EMG) signals acquired from the anatomical limb. Vagus nerve stimulation (VNS) is performed in response to the measured spinal reflex satisfying a positive reinforcement criterion. The EMG may be high density EMG (HD-EMG) measured using a sleeve with a high density array of electrodes (e.g., at least 100 electrodes in an arm sleeve).

Abstract: A therapeutic or diagnostic device comprises a wearable electrodes garment including electrodes disposed to contact skin when the wearable electrodes garment is worn, and an electronic controller operatively connected with the electrodes. The electronic controller is programmed to perform a method including: receiving surface electromyography (EMG) signals via the electrodes and extracting one or more motor unit (MU) action potentials from the surface EMG signals. The method may further include identifying an intended movement based at least on features representing the one or more extracted MU action potentials and delivering functional electrical stimulation (FES) effective to implement the intended movement via the electrodes of the wearable electrodes garment.