Abstract: The present disclosure provides methods for preparing MCL1 inhibitors or a salt thereof and related key intermediates.

Abstract: Disclosed are various systems, methods, and other embodiments for processing and recording defects. In one embodiment, an application is executed in a server that processes and records defects detected by a user at a receiving station client. Based on a retrieved vendor profile, the application selects an inspection sequence for a user to execute. The inspection sequence is selected based on a history of defects specified in the vendor profile. The application also determines whether supervision is needed based on the performance of the user.

Abstract: The present disclosure involves the receipt of inventory items in a materials handling facility. In one embodiment, a listing of inventory items associated with an inventory is maintained in a memory accessible to a computing device. An attempt is made to identify a match between a first image of a receivable item and a second image of one of the inventory items. If a match is successfully identified, an identifier associated with the one of the inventory items is rendered, where the identifier is to be associated with the receivable item.

Abstract: Disclosed are various embodiments of systems and methods for receiving shipment parcels at, for example, materials handling facilities. In some embodiments, a parcel monitoring system detects an exception for a shipment parcel. The parcel monitoring system identifies a vendor associated with the shipment parcel. In response to the exception being detected, the parcel monitoring system controls a conveyor system in accordance with an action specified by an exception handling rule for the vendor.

Abstract: The present disclosure involves the receipt of inventory items in a materials handling facility. In one embodiment, a listing of inventory items associated with an inventory is maintained in a memory accessible to a computing device. An attempt is made to identify a match between a first image of a receivable item and a second image of one of the inventory items. If a match is successfully identified, an identifier associated with the one of the inventory items is rendered, where the identifier is to be associated with the receivable item.

Abstract: The present disclosure involves the receipt of inventory items in a materials handling facility. In one embodiment, a listing of inventory items associated with an inventory is maintained in a memory accessible to a computing device. An attempt is made to identify a match between a first image of a receivable item and a second image of one of the inventory items. If a match is successfully identified, an identifier associated with the one of the inventory items is rendered, where the identifier is to be associated with the receivable item.

Abstract: Disclosed are various systems, methods, and other embodiments for processing and recording defects. In one embodiment, an application is executed in a server that processes and records defects detected by a user at a receiving station client. Based on a retrieved vendor profile, the application selects an inspection sequence for a user to execute. The inspection sequence is selected based on a history of defects specified in the vendor profile. The application also determines whether supervision is needed based on the performance of the user.

Abstract: Disclosed are various embodiments of systems and methods for receiving shipment parcels at, for example, materials handling facilities. In some embodiments, a parcel monitoring system detects an exception for a shipment parcel. The parcel monitoring system identifies a vendor associated with the shipment parcel. In response to the exception being detected, the parcel monitoring system controls a conveyor system in accordance with an action specified by an exception handling rule for the vendor.

Abstract: Disclosed are various embodiments of systems and methods for receiving shipment parcels at materials handling facilities. A parcel receiving system has an imaging tunnel through which shipment parcels received at a materials handling facility are passed. While a shipment parcel is passing through the imaging tunnel, a camera captures at least one image of the parcel. The parcel image is electronically analyzed to discover various tracking information and to detect various types of exceptions, such as damage to the parcel or defective tracking information. In addition, the captured image is stored in order to create a visual record of the parcel at the time of reception. This record may be used in a variety of ways, such as resolving or tracking exceptions or providing feedback to the vendor or shipment carrier. In addition, the parcel image may be viewed by a user to enable the user to detect and/or resolve an exception.

Abstract: Disclosed are various embodiments of a self healing andon system. One embodiment of the present disclosure includes a system comprising at least one server. The system further includes logic executed on the at least one server that retrieves a defect history associated with a vendor and at least one product from an inbound shipment from a memory. The at least one product is stocked in a materials handling facility, and the defect history is associated with a specified time period. The at least one server extracts at least one inventory defect from the defect history in a computer system and calculates an inventory defect rate. The at least one server imposes remedial measures if the inventory defect rate exceeds a specified threshold of the inventory defect rate.

Abstract: A system and computer-implemented method for automatically splitting a group of items into two or more shipment sets are disclosed. A shipment splitting analyzer may be configured to determine if and how the items should be split into shipment sets dependent on the number of unique or total items, item parameters, container parameters, facility configurations, transportation constraints, and/or business policies. Items may be dequeued from the group into proposed shipment sets directed to a target container. The shipment splitting analyzer may determine which items may be shipped together dependent on a cumulative volume and/or weight of the items, a size and/or weight capacity of the target container, and/or affinity information associated with the items. Over-sized items, over-weight items, and/or large quantities of single items may be removed for exception processing prior to splitting the items into shipment sets. Shipment splitting data may be analyzed for current performance and/or operational trends.

Abstract: Disclosed are various embodiments of systems and methods for receiving shipment parcels at materials handling facilities. A parcel receiving system has an imaging tunnel through which shipment parcels received at a materials handling facility are passed. While a shipment parcel is passing through the imaging tunnel, a camera captures at least one image of the parcel. The parcel image is electronically analyzed to discover various tracking information and to detect various types of exceptions, such as damage to the parcel or defective tracking information. In addition, the captured image is stored in order to create a visual record of the parcel at the time of reception. This record may be used in a variety of ways, such as resolving or tracking exceptions or providing feedback to the vendor or shipment carrier. In addition, the parcel image may be viewed by a user to enable the user to detect and/or resolve an exception.

Abstract: Disclosed are various embodiments of a self healing andon system. One embodiment of the present disclosure includes a system comprising at least one server. The system further includes logic executed on the at least one server that retrieves a defect history associated with a vendor and at least one product from an inbound shipment from a memory. The at least one product is stocked in a materials handling facility, and the defect history is associated with a specified time period. The at least one server extracts at least one inventory defect from the defect history in a computer system and calculates an inventory defect rate. The at least one server imposes remedial measures if the inventory defect rate exceeds a specified threshold of the inventory defect rate.

Abstract: Disclosed are various embodiments of systems and methods for receiving shipment parcels at materials handling facilities. A parcel receiving system has an imaging tunnel through which shipment parcels received at a materials handling facility are passed. While a shipment parcel is passing through the imaging tunnel, a camera captures at least one image of the parcel. The parcel image is electronically analyzed to discover various tracking information and to detect various types of exceptions, such as damage to the parcel or defective tracking information. In addition, the captured image is stored in order to create a visual record of the parcel at the time of reception. This record may be used in a variety of ways, such as resolving or tracking exceptions or providing feedback to the vendor or shipment carrier. In addition, the parcel image may be viewed by a user to enable the user to detect and/or resolve an exception.

Abstract: Disclosed are various embodiments of systems and methods for receiving shipment parcels at materials handling facilities. A parcel receiving system has an imaging tunnel through which shipment parcels received at a materials handling facility are passed. While a shipment parcel is passing through the imaging tunnel, a camera captures at least one image of the parcel. The parcel image is electronically analyzed to discover various tracking information and to detect various types of exceptions, such as damage to the parcel or defective tracking information. In addition, the captured image is stored in order to create a visual record of the parcel at the time of reception. This record may be used in a variety of ways, such as resolving or tracking exceptions or providing feedback to the vendor or shipment carrier. In addition, the parcel image may be viewed by a user to enable the user to detect and/or resolve an exception.