Patents by Inventor Eric Charles Reynolds

Eric Charles Reynolds has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20210161778
    Abstract: The present invention relates to improved complexes of amorphous calcium phosphate and/or amorphous calcium fluoride phosphate stabilised by phosphopeptides/phosphoproteins by addition of stannous ions. These complexes have anticariogenic properties useful to protect tooth structures as they remineralize (repair) early stages of dental caries and have other dental/medical applications (including anti-calculus, anti-erosion/corrosion and anti-dentinal hypersensitivity). Methods of making the complexes of the invention and of treatment or prevention of various dental conditions including dental caries, dental calculus, dental erosion/corrosion and dental hypersensitivity are also provided.
    Type: Application
    Filed: February 5, 2021
    Publication date: June 3, 2021
    Applicant: The University of Melbourne
    Inventor: Eric Charles REYNOLDS
  • Publication number: 20210079047
    Abstract: The invention relates to generation and use of cellular and humoral responses for the prevention and treatment of P. gingivalis related conditions and diseases.
    Type: Application
    Filed: November 13, 2020
    Publication date: March 18, 2021
    Applicant: Oral Health Australia PTY Ltd
    Inventors: Eric Charles REYNOLDS, Neil Martin O'BRIEN SIMPSON, Keith J. CROSS, Nada SLAKESKI
  • Patent number: 10912722
    Abstract: The present invention relates to improved complexes of amorphous calcium phosphate and/or amorphous calcium fluoride phosphate stabilised by phosphopeptides/phosphoproteins by addition of stannous ions. These complexes have anticariogenic properties useful to protect tooth structures as they remineralize (repair) early stages of dental caries and have other dental/medical applications (including anti-calculus, anti-erosion/corrosion and anti-dentinal hypersensitivity). Methods of making the complexes of the invention and of treatment or prevention of various dental conditions including dental caries, dental calculus, dental erosion/corrosion and dental hypersensitivity are also provided.
    Type: Grant
    Filed: December 24, 2014
    Date of Patent: February 9, 2021
    Assignee: THE UNIVERSITY OF MELBOURNE
    Inventor: Eric Charles Reynolds
  • Patent number: 10851138
    Abstract: Disclosed are methods related to the generation and use of cellular and humoral responses for the prevention and treatment of P. gingivalis related conditions and diseases, such as methods of preparing P. gingivalis antibodies, comprising immunizing a non-human animal with a chimeric or fusion protein, wherein the protein comprises a first peptide joined directly or through a linker to a second peptide or polypeptide, wherein (A) the first peptide comprises a region of a P. gingivalis trypsin-like enzyme and (B) the second peptide or polypeptide comprises an adhesin domain of P. gingivalis.
    Type: Grant
    Filed: September 18, 2018
    Date of Patent: December 1, 2020
    Assignee: ORAL HEALTH AUSTRALIA PTY LTD
    Inventors: Eric Charles Reynolds, Neil Martin O'Brien Simpson, Keith J Cross, Nada Slakeski
  • Publication number: 20200246378
    Abstract: The present invention relates to compositions for mineralizing a dental surface, in particular tooth enamel. Methods of mineralizing hypomineralized lesions (including subsurface lesions) in the tooth enamel caused by dental caries, dental corrosion and fluorosis are also provided. In particular, the invention relates to a method of mineralizing a dental surface or subsurface comprising contacting the dental surface or subsurface with a compound that is capable of increasing or maintaining the pH of a solution and a mineralizing agent.
    Type: Application
    Filed: April 20, 2020
    Publication date: August 6, 2020
    Applicant: THE UNIVERSITY OF MELBOURNE
    Inventor: Eric Charles Reynolds
  • Patent number: 10695370
    Abstract: The present invention relates to compositions for mineralizing a dental surface, in particular tooth enamel. Methods of mineralizing hypomineralized lesions (including subsurface lesions) in the tooth enamel caused by dental caries, dental corrosion and fluorosis are also provided. In particular, the invention relates to a method of mineralizing a dental surface or subsurface comprising contacting the dental surface or subsurface with a compound that is capable of increasing or maintaining the pH of a solution and a mineralizing agent.
    Type: Grant
    Filed: July 23, 2014
    Date of Patent: June 30, 2020
    Assignee: THE UNIVERSITY OF MELBOURNE
    Inventor: Eric Charles Reynolds
  • Publication number: 20200197486
    Abstract: The present invention relates to improved phosphopeptide stabilised amorphous calcium phosphate and/or amorphous calcium fluoride phosphate complexes and compositions containing those complexes. Methods of making the complexes of the invention and of treatment dental hypersensitivity are also provided. In one embodiment, the invention provides a stannous-associated phosphopeptide (PP) stabilized amorphous calcium phosphate (ACP) or amorphous calcium fluoride phosphate (ACFP) complex having a stannous ion content of equal to, or greater than, 1 mole of stannous per mole of PP but less than 4 moles of stannous per mole of PP.
    Type: Application
    Filed: March 14, 2018
    Publication date: June 25, 2020
    Applicant: THE UNIVERSITY OF MELBOURNE
    Inventor: Eric Charles Reynolds
  • Publication number: 20200123328
    Abstract: This invention relates to antibacterial compounds and compositions thereof. The invention also relates to the use of the compounds and compositions in methods of treating bacterial infections, particularly those bacterial infections including bacteria that exhibit antibiotic resistance. More specifically, the present invention provides a star shaped peptide polymer comprising a multifunctional core with a plurality of terminal arms extending therefrom, wherein the terminal arms are statistical or random peptide copolymers of at least a cationic amino acid residue and a hydrophobic amino acid residue.
    Type: Application
    Filed: November 2, 2017
    Publication date: April 23, 2020
    Inventors: Greg GuangHua Qiao, Neil Martin O'Brien-Simpson, Shu Jie Lam, Anton Richard Blencowe, Eric Charles Reynolds
  • Publication number: 20200054672
    Abstract: The present invention relates to compositions and their use for oral care. In particular, the compositions and methods are for maintaining oral health and/or treating various oral conditions such as gingivitis. The present invention relates to methods and uses of stabilized amorphous calcium phosphate (ACP) and/or stabilized amorphous calcium fluoride phosphate (ACFP) in the preparation of a medicament for reducing pathogenic oral bacteria at an oral site in an individual; increasing commensal oral bacteria at an oral site in an individual; decreasing the proportion of pathogenic oral bacteria at an oral site in an individual; inhibiting oral dysbiosis; reducing gingival inflammation in an individual in need thereof; treating gingivitis in an individual in need thereof; and treating chronic gingivitis in an individual in need thereof.
    Type: Application
    Filed: March 14, 2018
    Publication date: February 20, 2020
    Applicant: THE UNIVERSITY OF MELBOURNE
    Inventor: Eric Charles Reynolds
  • Publication number: 20190247459
    Abstract: This invention relates to compositions including antibacterial compounds. The invention also relates to the use of the compositions in methods of treating bacterial infections. In one aspect the present invention also provides a method of increasing the susceptibility of bacteria to the anti-bacterial activity of a compound, the method comprising contacting the bacteria with a star shaped peptide polymer of the invention, thereby increasing the susceptibility of the bacteria to the anti-bacterial activity of the compound. Preferably, the method further includes the step of contacting the bacteria with the compound for which the bacteria have increased susceptibility to. The invention is further relates to the combination of a star shaped peptide polymer and an anti-bacterial compound that restore the sensitivity of antibiotic resistant bacteria to antibiotics that are otherwise ineffective when administered alone.
    Type: Application
    Filed: November 2, 2017
    Publication date: August 15, 2019
    Inventors: Greg GuangHua Qiao, Neil Martin O'Brien-Simpson, Shu Jie Lam, Eric Charles Reynolds
  • Publication number: 20190194263
    Abstract: The invention relates to generation and use of cellular and humoral responses for the prevention and treatment of P. gingivalis related conditions and diseases.
    Type: Application
    Filed: September 18, 2018
    Publication date: June 27, 2019
    Applicant: Oral Health Australia PTY Ltd
    Inventors: Eric Charles REYNOLDS, Neil Martin O'BRIEN SIMPSON, Keith J. CROSS, Nada SLAKESKI
  • Publication number: 20180008518
    Abstract: The present invention relates to compositions for mineralizing a dental surface, in particular tooth enamel. Methods of mineralizing hypomineralized lesions (including subsurface lesions) in the tooth enamel caused by dental caries, dental corrosion and fluorosis are also provided.
    Type: Application
    Filed: December 24, 2015
    Publication date: January 11, 2018
    Applicant: THE UNIVERSITY OF MELBOURNE
    Inventor: Eric Charles Reynolds
  • Publication number: 20170333296
    Abstract: The present invention relates to compositions and methods for mineralizing a dental surface or subsurface including providing a composition including stabilized ACP and a source of fluoride ions.
    Type: Application
    Filed: May 31, 2017
    Publication date: November 23, 2017
    Applicant: THE UNIVERSITY OF MELBOURNE
    Inventor: Eric Charles Reynolds
  • Patent number: 9814662
    Abstract: The present invention relates to a phosphopeptide-stabilized amorphous calcium phosphate and/or amorphous calcium fluoride phosphate complex, wherein the complex is formed at a pH of below 7.0. Methods of making such complexes are also provided. The complexes are useful in dental applications, in particular in dental remineralization.
    Type: Grant
    Filed: March 3, 2016
    Date of Patent: November 14, 2017
    Assignee: The University of Melbourne
    Inventor: Eric Charles Reynolds
  • Publication number: 20170247420
    Abstract: The invention relates to generation and use of cellular and humoral responses for the prevention and treatment of P. gingivalis related conditions and diseases.
    Type: Application
    Filed: December 6, 2016
    Publication date: August 31, 2017
    Applicant: Oral Health Australia Pty Ltd.
    Inventors: Eric Charles Reynolds, Neil Martin O'Brien Simpson, Keith J. Cross, Nada Slakeski
  • Patent number: 9668945
    Abstract: The present invention relates to compositions and methods for mineralizing a dental surface or subsurface including providing a composition including stabilized ACP and a source of fluoride ions.
    Type: Grant
    Filed: February 9, 2007
    Date of Patent: June 6, 2017
    Assignee: THE UNIVERSITY OF MELBOURNE
    Inventor: Eric Charles Reynolds
  • Patent number: 9518109
    Abstract: The invention relates to generation and use of cellular and humoral responses for the prevention and treatment of P. gingivalis related conditions and diseases.
    Type: Grant
    Filed: September 16, 2014
    Date of Patent: December 13, 2016
    Assignee: ORAL HEALTH AUSTRALIA PTY LTD
    Inventors: Eric Charles Reynolds, Neil Martin O'Brien Simpson, Keith J Cross, Nada Slakeski
  • Publication number: 20160317404
    Abstract: The present invention relates to improved complexes of amorphous calcium phosphate and/or amorphous calcium fluoride phosphate stabilised by phosphopeptides/phosphoproteins by addition of stannous ions. These complexes have anticariogenic properties useful to protect tooth structures as they remineralize (repair) early stages of dental caries and have other dental/medical applications (including anti-calculus, anti-erosion/corrosion and anti-dentinal hypersensitivity). Methods of making the complexes of the invention and of treatment or prevention of various dental conditions including dental caries, dental calculus, dental erosion/corrosion and dental hypersensitivity are also provided.
    Type: Application
    Filed: December 24, 2014
    Publication date: November 3, 2016
    Applicant: THE UNIVERSITY OF MELBOURNE
    Inventor: Eric Charles REYNOLDS
  • Publication number: 20160175226
    Abstract: The present invention relates to a phosphopeptide-stabilized amorphous calcium phosphate and/or amorphous calcium fluoride phosphate complex, wherein the complex is formed at a pH of below 7.0. Methods of making such complexes are also provided. The complexes are useful in dental applications, in particular in dental remineralisation.
    Type: Application
    Filed: March 3, 2016
    Publication date: June 23, 2016
    Inventor: Eric Charles REYNOLDS
  • Publication number: 20160158283
    Abstract: The present invention relates to compositions for mineralizing a dental surface, in particular tooth enamel. Methods of mineralizing hypomineralized lesions (including subsurface lesions) in the tooth enamel caused by dental caries, dental corrosion and fluorosis are also provided. In particular, the invention relates to a method of mineralizing a dental surface or subsurface comprising contacting the dental surface or subsurface with a compound that is capable of increasing or maintaining the pH of a solution and a mineralizing agent.
    Type: Application
    Filed: July 23, 2014
    Publication date: June 9, 2016
    Applicant: THE UNIVERSITY OF MELBOURNE
    Inventor: Eric Charles Reynolds