Abstract: The present invention relates to antibodies that specifically bind to one or more of IL-4, IL-13, IL-33, TSLP, and p40. The present invention further relates to antibodies that bind to one of IL-4, IL-13, IL-33, or TSLP. The invention further relates to multispecific antibodies that specifically bind to IL-4 and IL-13, and at least one other target. The present invention relates to multispecific antibodies that bind IL-4, IL-13, and one of IL-33, TSLP, or p40. The present invention also pertains to related molecules, e.g. nucleic acids which encode such antibodies or multispecific antibodies, compositions, and related methods, e.g., methods for producing and purifying such antibodies and multispecific antibodies, and their use in diagnostics and therapeutics.

Abstract: A system for sensing interstitial glucose includes an elongated structure that defines a fluid delivery conduit having at least one fluid outlet, and a sensor formed on an external surface of the elongated structure and comprising a reference electrode, a counter electrode, and a working electrode arranged planarly in a sequence along a longitudinal axis of the elongated structure and configured to sense an interstitial glucose level of a patient.

Abstract: In some embodiments, a computer-implemented method includes capturing an image for each flash unit of an electronic device, each image being illuminated during the capturing of the image; obtaining a normalized image from one or more of the illuminated images; and using an illumination-based optimization framework to generate an enhanced three-dimensional (3D) depth image, the illumination-based optimization framework being based on the illuminated image. In some embodiments of the computer-implemented method, the illumination-based optimization framework incorporates the normalized image and 3D depth data associated with the captured image into the generation of the enhanced 3D depth image.

Abstract: The present disclosure provides vector stuffer polynucleotides and compositions thereof, including expression constructs and vectors, such as viral vectors and methods of delivering a therapeutic agent (e.g., inhibitory nucleic acid) to a mammal or treating a disease.

Abstract: In various aspects and embodiments, the present disclosure provides methods for making glycosylated products, as well as bacterial cells and uridine diphosphate (UDP)-dependent glycosyltransferase (UGT) enzymes useful for the same. In other aspects and embodiments, the disclosure provides methods for high yield and/or high purity recovery of such glycoside products from microbial cultures or cell free reactions. In various aspects and embodiments, the disclosure provides for whole cell bioconversion processes involving the glycosylation of a desired substrate, and/or the recovery of the glycosylated product at high yield and/or high purity.

Abstract: An extraction device can include a delivery shaft having a lumen and a distal end, a first wire forming a first arc and being positionable distal to the distal end of the delivery shaft while ends of the first arc are at a distalmost end of the delivery shaft, and a second wire forming a second arc and being positionable distal to the distal end of the delivery shaft while ends of the second arc are at the distalmost end of the delivery shaft. A distalmost extent of the first wire is distal to a distalmost extent of the second wire. The first wire and the second wire are separately retractable relative to the delivery shaft.

Abstract: Embodiments of golf club heads with energy storage characteristics are presented herein. In some embodiments, a golf club head comprises a hollow body comprising a strikeface, a heel region, a toe region opposite the heel region, a sole, a top rail and an inflection point. The inflection point provides increase bending of the strikeface thereby providing performance enhancement over clubs without an inflection point.

Abstract: Embodiments of golf club heads having adjustable weighting systems with a plurality of discrete attachment locations capable of receiving one or more weights are described herein. The golf club heads described herein provide user adjustability of club head center of gravity to adjust ball flight while maintaining a high moment of inertia and low and back center of gravity position.

Abstract: A set of user interface tools is described facilitating asynchronous adjudication of one or more regions-of-interest in a medical image by a group of two or more graders, each of which has access to the set of tools in a workstation environment. The set of tools include (1) a feature for enabling the graders to assess the medical image and manually delineate one or more specific regions-of-interest (ROI) in the medical image, (2) a feature for assessing the ROI(s) delineated by other graders, including display of the ROI delineated by other graders; (3) dialog features for explaining and discussing the assessments, including a text feature for discussing the assessments. The dialog features and the ROIs delineated by all the graders are visible to all the graders on the workstation display as they collectively adjudicate the medical image in a round-robin manner. The set of tools further include (4) a feature for manually verifying grader agreement with the other graders' assessments.

Abstract: A massage device includes a drive motor, a drive wheel operatively coupled to the drive motor to rotate upon energization of the drive motor, the drive wheel having an eccentric post situated thereon, a movable bracket that includes one or more massaging elements rotatably mounted on the bracket, a rotational movement-to-linear movement translation coupler operatively coupled to the drive wheel and to the movable bracket, and an exterior sleeve defining a handle for a user to hold the massage device. When the drive motor is energized, the drive motor causes the drive wheel to rotate, the rotating drive wheel causing the movable frame and the one or more massaging elements to move with a linear, reciprocating motion.

Abstract: An information handling system executing an intelligent throughput performance analysis and issue detection system may comprise a network interface device to establish a wireless link with a wireless network and a processor to execute a neural network trained to predict wireless link throughput values based on controlled connectivity testing metrics gathered in a controlled laboratory from tested information handling systems. The processor may gather measured throughput of the wireless link and operational connectivity metrics for the information handling system that describe antenna positional information, antenna adaptation controller parameters, signal strength measurements, and wireless link performance metrics. The neural network may output, based on the gathered operational connectivity metrics a predicted throughput value that differs from the measured throughput by a maximum tolerance.

Abstract: Systems, methods, and devices are disclosed for training a model. Media data is separated into one or more clusters, each cluster based on a feature from a first model. The media data of each cluster is sampled and, based on an analysis of the sampled media data, an accuracy of the media data of each cluster is determined. The accuracy is associated with the feature from the first model. Based on a subset dataset of the media data being outside a threshold accuracy, the subset dataset is automatically forwarded to a crowd source service. Verification of the subset dataset is received from the crowd source service, and the verified subset dataset is added to the first model.

Abstract: An apparatus, system and method are provided for a wireless electrical stimulation. The apparatus generally includes at least two electrical stimulation units. Each electrical stimulation unit includes electrodes connected to the unit. The apparatus also includes a receiver configured for receiving the one or more control signals from a remote controller for remotely, wirelessly controlling each of the electrical stimulation units to selectively apply a time-varying electric potential to the electrodes to provide an electrical stimulation to tissue in electrical contact with the electrodes. The apparatus generally applies to a foot of a human body.

Abstract: Systems, methods, and devices are disclosed for training a model. Media data is separated into one or more clusters, each cluster based on a feature from a first model. The media data of each cluster is sampled and, based on an analysis of the sampled media data, an accuracy of the media data of each cluster is determined. The accuracy is associated with the feature from the first model. Based on a subset dataset of the media data being outside a threshold accuracy, the subset dataset is automatically forwarded to a crowd source service. Verification of the subset dataset is received from the crowd source service, and the verified subset dataset is added to the first model.

Abstract: An apparatus to detect a liquid in a wafer processing device is provided. The apparatus includes a first conductor proximate the wafer processing device. The apparatus includes a second conductor spaced apart from the first conductor and proximate the wafer processing device. The apparatus includes a liquid absorption material surrounding the first conductor and the second conductor. The apparatus includes a current source coupled to the first conductor. The apparatus includes a current detector coupled to at least one of the first conductor or the second conductor. The liquid absorption material establishes a conductive pathway between the first conductor and the second conductor when the liquid absorption material absorbs the liquid in the wafer processing device. A current is generated, by the current source, in at least one of the first conductor or the second conductor through the conductive pathway. The current detector detects the current.

Abstract: Disclosed is a positioning device for a fence supplemented with a pet guardrail. The pet guardrail is fixed to a side of an existing fence in a side-attaching manner, and an upper crossbar and a lower crossbar of the pet guardrail are fixed to an outer side of the existing fence by bolts and covered and protected by front and rear cover plates, and both ends of the upper crossbar and lower crossbar are sheathed with a side sleeve for protection. In this way, the grid spacing of the existing fence can be reduced to prevent pets from escaping, and the overall appearance is aesthetic, and the overall structure avoids people or pets from being scratched by the bolts and just requires simple operations for the installation.

Abstract: An apparatus, system and method are provided for a wireless electrical stimulation. The apparatus generally includes at least two electrical stimulation units. Each electrical stimulation unit includes electrodes connected to the unit. The apparatus also includes a receiver configured for receiving the one or more control signals from a remote controller for remotely, wirelessly controlling each of the electrical stimulation units to selectively apply a time-varying electric potential to the electrodes to provide an electrical stimulation to tissue in electrical contact with the electrodes. The apparatus generally applies to a foot of a human body.

Abstract: Disclosed is a positioning device for a fence supplemented with a pet guardrail. The pet guardrail is fixed to a side of an existing fence in a side-attaching manner, and an upper crossbar and a lower crossbar of the pet guardrail are fixed to an outer side of the existing fence by bolts and covered and protected by front and rear cover plates, and both ends of the upper crossbar and lower crossbar are sheathed with a side sleeve for protection. In this way, the grid spacing of the existing fence can be reduced to prevent pets from escaping, and the overall appearance is aesthetic, and the overall structure avoids people or pets from being scratched by the bolts and just requires simple operations for the installation.

Abstract: A positioning device for fence supplemented with pet guardrail comprises: an upper embedding slot and a lower embedding slot having face-to-face openings and extending axially being respectively formed on an opposite outside of the upper crossbar and the lower crossbar of the pet guardrail, for embedding the upper and lower ends of the straight rod and fixing the straight rod via the positioning peg from the inner side of the upper crossbar and the lower crossbar to avoid the exposure of the positioning peg and omitting the installation of the front cover plate on the front side of the upper crossbar and the lower crossbar, and moreover, the side cover installed and covered on the left and right ends of the upper crossbar and the side cover facing the end of side pole of the existing fence being an circular arc surface, thereby meeting the installation inclination angle of the existing fence. The configuration of the circular arc surface enables the side cover to maintain attached with the side pole.

Abstract: Techniques and systems include predicting various health conditions using a photoplethysmography (PPG) signal or a video signal based on images of a patient's fingertip or other body portion captured using a mobile device. The video signal may be transformed into a pseudo PPG signal to measure blood volume changes in the patient's blood flow to derive data indicating a disease state or health-related characteristic, such as blood oxygen level, blood glucose level, heart rate variability, hemoglobin, respiration rate, or arrhythmia. Techniques involve real-time environment assessment and problematic issue detection, training an artificial intelligence (AI) model to measure signal quality so as to select high-quality signals from a range of signals, and domain adaption and transfer learning to make use of publicly available datasets.