Abstract: The present disclosure provides implantable bone distraction devices and methods of using same to elongate a bone.

Abstract: The present disclosure provides implantable bone distraction devices and methods of using same to elongate a bone.

Abstract: A computer-implemented method for providing diagnosis aid for diagnosing spinal condition by providing feature(s) of a subject's spine. The method includes: a receiving step, receiving subject-associated imaging signals, the imaging signals representing at least a part of the subject's spine; a first processing step, computing a first set of spine data based on a first imaging signal; a first prediction step, computing a first output relating to a first anatomical structure of the subject's spine based on the first set of spine data; a second processing step, computing a second set of spine databased on a second imaging signal; and a second prediction step, computing a second output relating to a second anatomical structure of the subject's spine based on the second set of spine data and the first output, the second output including a second feature of the subject's spine representing at least one spinal condition.

Abstract: A system for evaluating the evolution of the structure of a subject's bone, the system including an implantable medical device including an implant body intended to be attached to the bone of the subject and at least one reflector coupled to the implant body, the reflector being configured to reflect an electromagnetic signal and being embedded in a surrounding tissue of the subject when the implant body is attached to the subject's bone and a calculation module configured to compute a parameter representative of the structure of the subject's bone, wherein the parameter is computed from a reflected signal corresponding to a reflection, on the reflector embedded in the surrounding tissue of the subject, of an excitation signal including at least one frequency in the characteristic frequency range of the reflector, the reflected signal being representative of at least one electrical property of the surrounding tissue.

Abstract: The present disclosure provides implantable bone distraction devices and methods of using same to elongate a bone.

Abstract: The present invention relates to pharmaceutical aerosols comprising a ?-hairpin peptidomimetic of formula cyclo(-OctG-Glu-Thr-Ala-Ser-Ile-Pro-Pro-Gln-Lys-Tyr-DPro-Pro-), or a pharmaceutically acceptable salt thereof, having inhibitory activity against human neutrophil elastase. It further relates to solid or liquid pharmaceutical compositions and kits for preparing and administering such aerosols. The invention can be used for the prevention, management or treatment of pulmonary diseases, such as alpha-1 antitrypsin deficiency (AATD), cystic fibrosis (CF), non-cystic fibrosis bronchiactasis (NCFB), or chronic obstructive pulmonary disease (COPD), or infections, or diseases, or conditions of the lungs, being mediated by or resulting from human neutrophil elastase activity.

Abstract: A device for determining features of a subject's spine, including a processing unit having: a first module configured to receive a first set of spine image data of the subject, and to compute, based on spine image data of an examined spine, at least one first output relating to a first anatomical structure of the examined spine, at least one first output including a first feature of the examined spine; a second module configured to receive a first output of the first module and a second set of spine image data of the subject, and further configured to compute, based on spine image data of the examined spine and the first output, a second output relating to a second anatomical structure of the examined spine, and including a second feature of the examined spine.

Abstract: An implantable bone elongation device including an inner rod defining an internal cavity housing a rotational actuator having an output shaft connected to a lead screw disposed at the end of the inner rod and in threaded engagement with a threaded inner surface of an outer rod. Rotation of the lead screw converts rotation motion into linear motion resulting in telescopic movement of the outer rod relative to the inner rod. Rotational motion is converted into linear motion by components disposed in a parallel configuration thereby minimizing the overall length of the bone elongating device while maintaining a maximum stroke length. In various embodiments, additional components, such as electronic circuit boards, electrical power supply or battery power source, may be housed within the internal cavity formed by the inner rod.

Abstract: A method of communication between a remote action manager and a communication box, for interacting with equipment connected to the communication box, by creating an association of a communication mechanism with the box, receiving an action request at the action manager destined for the equipment, identifying the communication mechanism associated with the box, and communicating the action request to the box via the identified communication mechanism.

Abstract: Disclosed is an invasive intervertebral fusion cage, the intervertebral fusion cage including: a vibration sensor; and a frame configured to support surrounding tissues used to create a bone fusion process; wherein the vibration sensor is integral with the frame in order to measure the mechanical vibrations the vibrations arising from the medium consisting of the frame, the surrounding tissues and/or the fusionned bone, and wherein the intervertebral fusion cage does not include a vibration excitation transducer. Also disclosed is a remote medical monitoring device including a receiver for receiving data from an intervertebral fusion cage, reflecting the mechanical vibrations of a medium and a calculator computing from the received data a medium indicator by: determining at least one vibration pattern of the received data; comparing the at least one vibration pattern with at least one reference model; generating a medium indicator in function of the comparing step.

Abstract: The present invention relates to pharmaceutical aerosols comprising a ?-hairpin peptidomimetic of formula cyclo(-OctG-Glu-Thr-Ala-Ser-Ile-Pro-Pro-Gln-Lys-Tyr-DPro-Pro-), or a pharmaceutically acceptable salt thereof, having inhibitory activity against human neutrophil elastase. It further relates to solid or liquid pharmaceutical compositions and kits for preparing and administering such aerosols. The invention can be used for the prevention, management or treatment of pulmonary diseases, such as alpha-1 antitrypsin deficiency (AATD), cystic fibrosis (CF), non-cystic fibrosis bronchiactasis (NCFB), or chronic obstructive pulmonary disease (COPD), or infections, or diseases, or conditions of the lungs, being mediated by or resulting from human neutrophil elastase activity.

Abstract: The present invention relates to pharmaceutical aerosols comprising a ?-hairpin peptidomimetic of formula cyclo(-OctG-Glu-Thr-Ala-Ser-Ile-Pro-Pro-Gln-Lys-Tyr-DPro-Pro-), or a pharmaceutically acceptable salt thereof, having inhibitory activity against human neutrophil elastase. It further relates to solid or liquid pharmaceutical compositions and kits for preparing and administering such aerosols. The invention can be used for the prevention, management or treatment of pulmonary diseases, such as alpha-1 antitrypsin deficiency (AATD), cystic fibrosis (CF), non-cystic fibrosis bronchiactasis (NCFB), or chronic obstructive pulmonary disease (COPD), or infections, or diseases, or conditions of the lungs, being mediated by or resulting from human neutrophil elastase activity.

Abstract: Method of communication between a remote action manager (14) and a communication box (5) for interacting with a device (1) connected to said communication box (5), this box (5) and this device (1) being included in a local network, the box (5) being connected to said remote action manager (14) by way of an integrated access apparatus (25) having a public address, this method comprising the following steps—association of a communication mechanism with said box (5), this association being stored in a database (15) associated with said action manager (14); —reception, by the action manager (14), of a request (16) for action destined for said device; —identification, in said database (15), of the communication mechanism associated with said box (5); —communication of the request (16) for action to said communication box (5) via the identified communication mechanism.

Abstract: Disclosed is an invasive intervertebral fusion cage, the intervertebral fusion cage including: a vibration sensor; and a frame configured to support surrounding tissues used to create a bone fusion process; wherein the vibration sensor is integral with the frame in order to measure the mechanical vibrations the vibrations arising from the medium consisting of the frame, the surrounding tissues and/or the fusionned bone, and wherein the intervertebral fusion cage does not include a vibration excitation transducer. Also disclosed is a remote medical monitoring device including a receiver for receiving data from an intervertebral fusion cage, reflecting the mechanical vibrations of a medium and a calculator computing from the received data a medium indicator by: determining at least one vibration pattern of the received data; comparing the at least one vibration pattern with at least one reference model; generating a medium indicator in function of the comparing step.

Abstract: The present invention relates to pharmaceutical aerosols comprising a ?-hairpin peptidomimetic of formula cyclo(-OctG-Glu-Thr-Ala-Ser-Ile-Pro-Pro-Gln-Lys-Tyr-DPro-Pro-), or a pharmaceutically acceptable salt thereof, having inhibitory activity against human neutrophil elastase. It further relates to solid or liquid pharmaceutical compositions and kits for preparing and administering such aerosols. The invention can be used for the prevention, management or treatment of pulmonary diseases, such as alpha-1 antitrypsin deficiency (AATD), cystic fibrosis (CF), non-cystic fibrosis bronchiactasis (NCFB), or chronic obstructive pulmonary disease (COPD), or infections, or diseases, or conditions of the lungs, being mediated by or resulting from human neutrophil elastase activity.

Abstract: A frame delimits an inside space and includes a peripherally closed side wall and two transverse openings or one transverse opening and a transverse end wall. It is capable of allowing the airtight engagement of the open free edge of a side wall in film form of a receptacle that is at least partially deformable. It is specially designed for the creation of a 3D container. The frame is also able to act as a support for at least one functional port or attachment port of a functional element. Its axial size is adequate for delimiting a space of a size that is at least equal to the axial dimension of the functional element, so that the latter can be completely housed within the inside space.

Abstract: A processing receptacle for a biopharmaceutical product includes a pocket configured to accommodate the biopharmaceutical product that can assume a flat-folded state, an expanded state, or any intermediate state in between, a processing element having an active inner portion, a rigid protective chamber to protect the processing element, and at least one opening for introducing the product into the receptacle and/or for draining the contents from the receptacle. A portion of the protective chamber is rigidly attached to a portion of the pocket and movement of the pocket up or down brings about movement of the protective chamber; the processing element and the protective chamber are arranged to be independent from one another relative to their movements.

Abstract: Novel template-fixed ?-hairpin peptidomimetics of the general formula (I): cyclo[P1-P2-P3-P4-P5-P6-P7-P8-P9-P10-P11-P12-P13-P14-T1-T2] wherein the single elements T or P are ?-amino acid residues connected in either direction which, depending on their positions in the chain, are as defined in the description and the claims, and salts thereof, have the property of antagonizing the biological effect of the receptor FPR1. They can be used as medicaments to treat or prevent diseases or conditions in the areas of inflammatory diseases, allergic conditions, immunological disorders, neuroinflammation, neurological disorders, obstructive airway diseases, infectious diseases, ischemic reperfusion injuries and proliferative disorders such as e.g. cancer. These ?-hairpin peptidomimetics can be manufactured by a process which is based on a mixed solid- and solution phase synthetic strategy.

Abstract: A frame delimits an inside space and includes a peripherally closed side wall and two transverse openings or one transverse opening and a transverse end wall. It is capable of allowing the airtight engagement of the open free edge of a side wall in film form of a receptacle that is at least partially deformable. It is specially designed for the creation of a 3D container. The frame is also able to act as a support for at least one functional port or attachment port of a functional element. Its axial size is adequate for delimiting a space of a size that is at least equal to the axial dimension of the functional element, so that the latter can be completely housed within the inside space.

Abstract: A frame delimits an inside space and includes a peripherally closed side wall and two transverse openings or one transverse opening and a transverse end wall. It is capable of allowing the airtight engagement of the open free edge of a side wall in film form of a receptacle that is at least partially deformable. It is specially designed for the creation of a 3D container. The frame is also able to act as a support for at least one functional port or attachment port of a functional element. Its axial size is adequate for delimiting a space of a size that is at least equal to the axial dimension of the functional element, so that the latter can be completely housed within the inside space.