Abstract: Some embodiments include a system comprising a bioreactor operable to vitally support one or more microorganisms. The bioreactor includes a bioreactor cavity configured to contain the microorganism(s) and a fluidic support medium, one or more bioreactor walls at least partially enclosing the bioreactor cavity and having at least one bioreactor wall material, one or more bioreactor fittings, one or more gas delivery devices, and one or more flexible tubes. The at least one bioreactor wall material can be flexible, the bioreactor can be be autoclaved one or more times to sterilize the bioreactor, and the bioreactor is can be gathered up by at least one of folding or rolling up the bioreactor. Other embodiments of related systems and methods are also disclosed.

Abstract: A method for retrieving excess pharmaceutical process fluid from the hold-up volume of a primary fluid filtration device. The hold-up volume is the volume of excess process fluid which accumulates in the bottom of the filter housing below the outlet opening thereof. Because it is considered valuable, the excess pharmaceutical process fluid is retrieved from the lower housing (22) via a drainage port (23) formed therein below the level of the outlet. The excess process fluid is then filtered in a supplemental filtration device (100) that is connected to the drainage port. The supplemental filtration device has a smaller volumetric capacity than the capacity of the primary fluid filtration device.

Abstract: A fluid filtration device is disclosed which includes a capsule housing having an upper housing portion defining an axial fluid inlet and a lower housing portion defining an axial fluid outlet, a filter assembly including an elongated mounting post and a plurality of filtration cells supported on the mounting post in axially spaced apart relationship, and structure operatively associated with the mounting post and the lower housing portion for effectuating axial compression of the filtration cells relative to the mounting post when the mounting post is engaged in the lower housing portion during assembly.