Abstract: An intra-calvarial implant (ICI) includes one or more electrodes for sensing electrical signals from a brain of a mammal and for electrically stimulating one or more regions of the brain. The electrode(s) are implanted between an outer table and an inner table of the calvarial bone without fully penetrating the inner table, at least one reference electrode, an electronic circuitry module operatively connected to the one or more electrode(s) and to the reference electrode and for controlling the sensing and the stimulating, for at least partially processing the sensed electrical signals to obtain data for storing the data and for wirelessly transmitting the data to an external receiver. The ICI also includes a power harvesting device suitably electrically connected to one or more components of the electronic circuitry module of the ICI for energizing one or more components of the ICI. An ICI system includes ICI(s) and an external controller.