Abstract: Methods and systems for assessing a stroke rehabilitation outcome of a subject include a home-based brain-controlled interface (BCI) apparatus and a computer processor in communication with the BCI apparatus. The BCI apparatus has i) a portable brain signal acquisition headset that acquires a brain signal from a subject; ii) an orthosis device having a body part interface configured to be coupled to a body part of the subject and a plurality of sensors that generate force data and movement data; and iii) a BCI component that receives the brain signal from the brain signal acquisition headset. The BCI component is capable of controlling the orthosis device. The computer processor performs instructions to process input data to output a rehabilitation outcome prediction for the subject, where the input data includes the brain signal, the force data, the movement data, and background information about the subject.

Abstract: Among the various aspects of the present disclosure is the provision of a noninvasive and localized brain liquid biopsy using focused ultrasound. Briefly, therefore, the present disclosure is directed to methods and systems to identify brain lesion or tumor characteristics without the need for a solid brain biopsy.

Abstract: Systems including intra-calvarial implants and/or subdermal implants are capable of stimulating cortical regions and sensing and electrical signals is implanted within or on a calvarial bone of a skull. The implants have current steering capability to change the current density profiles applied to selected cortical regions underlying the implant. The systems may track changes in the position and/or spatial parameters of a neural network by recording cortical electrical signals and processing them to compute the values of one or more network activity biomarkers. The systems may spatially track changes detected in network anatomical position and deliver the stimulation of the cortex to the network detected position by using current steering methods.

Abstract: Systems for performing human motor assessments remotely include a wearable orthosis device having a sensor, an imaging device, and a computer. The computer includes instructions that cause the computer to perform a method comprising receiving images from the imaging device; making a measurement of a movement from the images, the movement performed by a patient; and calculating a motor assessment metric using the measurement of the movement and data from the sensor.

Abstract: An intra-calvarial implant (ICI) includes a housing including a sealed compartment having a top part, a bottom part and a side wall, and a current directing mechanism extending from the bottom part of the sealed compartment. The ICI also includes one or more electrodes for sensing electrical signals from the brain and/or for electrically stimulating one or more regions of the brain. The ICI includes at least one auxiliary electrode (that may be a reference and/or source/sink electrode) and an electronic circuitry module (ECM), sealingly disposed within the sealed compartment and operatively connected to the one or more electrodes and to the at least one reference electrode. The ECM controls the operation of the ICI and wirelessly communicates with an external telemetry device. The ICI includes a power harvesting device electrically connected to the ECM of the ICI for providing power thereto.

Abstract: Systems for treating a mood disorder in a patient includes implantable device(s) including one or more electrodes for sensing cortical signals and for stimulating one or more brain regions. Processor/controller(s) in communication with the electrode(s) receive and process cortical signals from electrode(s) and control the stimulating of brain region(s). The system includes portable communication device(s) operable by the patient and having software for acquiring ecological mood assessment (EMA) data representative of the patient's mood and communicating the EMA data to the processor/controller(s) and/or to at least one remote processor. Sensors may also be used to record patient data. The data is processed by the processor/controller(s), and/or by a processor of the portable communication device and/or by the remote processor(s) for modulating and/or controlling the stimulation the brain region(s) to treat the mood disorder. The implantable device(s) may include a power source.

Abstract: A system to deliver current to an area of interest of a subject is described that includes a power source, a controller electrically coupled to the power source, at least one first electrode electrically coupled to the controller, and at least one second electrode electrically coupled to one of the power source and the controller, with the area of interest positioned between the at least one first electrode and the at least one second electrode. A method of stimulating at least one of bone growth, tissue healing and pain control within an area of interest of a patient is described that includes inserting first and second electrode spaced at a predetermined distance, and further includes directing an electric current between the first and second electrodes so that at least a portion of the electric current passes through the area of interest positioned between the first electrode and the second electrode.

Abstract: A system for controlling a body part includes a number of sensing devices that sense signals from a hemisphere of a brain. A signal translating unit translates the signals into a command signal for controlling the body part, which is on a same side of the body as the hemisphere of the brain. A prosthetic device receives the command signal from the signal translating unit and manipulates the body part in response to the command signal.

Abstract: A system for controlling a body part includes a number of sensing devices that sense signals from a hemisphere of a brain. A signal translating unit translates the signals into a command signal for controlling the body part, which is on a same side of the body as the hemisphere of the brain. A prosthetic device receives the command signal from the signal translating unit and manipulates the body part in response to the command signal.

Abstract: A brain computer interface (BCI) system for modulating cognitive performance. The system includes one or more electrode sets for sensing signals associated with neuronal electrical activity in one or more cortical regions of the user and for providing stimulating signals to one or more target brain regions, at least one processor/controller in communication with the one or more electrode sets, and at least one power source. The processor/controller is programmed to process signals sensed in the one or more cortical regions for detecting an indication associated with an intention to perform a cognitive task and/or the presentation of a cognitive task and/or the performing of a cognitive task, and to control the stimulating of the one or more target brain regions responsive to the detecting of the indication for modulating the cognitive performance of the user. The target brain regions may include cortical regions, deep brain structures, and combinations thereof.

Abstract: A system to deliver current to an area of interest of a subject is described that includes a power source, a controller electrically coupled to the power source, at least one first electrode electrically coupled to the controller, and at least one second electrode electrically coupled to one of the power source and the controller, with the area of interest positioned between the at least one first electrode and the at least one second electrode. A method of stimulating at least one of bone growth, tissue healing and pain control within an area of interest of a patient is described that includes inserting first and second electrode spaced at a predetermined distance, and further includes directing an electric current between the first and second electrodes so that at least a portion of the electric current passes through the area of interest positioned between the first electrode and the second electrode.

Abstract: A system to deliver current to an area of interest of a subject is described that includes a power source, a controller electrically coupled to the power source, at least one first electrode electrically coupled to the controller, and at least one second electrode electrically coupled to one of the power source and the controller, with the area of interest positioned between the at least one first electrode and the at least one second electrode. A method of stimulating at least one of bone growth, tissue healing and pain control within an area of interest of a patient is described that includes inserting first and second electrode spaced at a predetermined distance, and further includes directing an electric current between the first and second electrodes so that at least a portion of the electric current passes through the area of interest positioned between the first electrode and the second electrode.

Abstract: A system to deliver current to an area of interest of a subject is described that includes a power source, a controller electrically coupled to the power source, at least one first electrode electrically coupled to the controller, and at least one second electrode electrically coupled to one of the power source and the controller, with the area of interest positioned between the at least one first electrode and the at least one second electrode. A method of stimulating at least one of bone growth, tissue healing and pain control within an area of interest of a patient is described that includes inserting first and second electrode spaced at a predetermined distance, and further includes directing an electric current between the first and second electrodes so that at least a portion of the electric current passes through the area of interest positioned between the first electrode and the second electrode.

Abstract: A system for controlling a body part includes a number of sensing devices that sense signals from a hemisphere of a brain. A signal translating unit translates the signals into a command signal for controlling the body part, which is on a same side of the body as the hemisphere of the brain. A prosthetic device receives the command signal from the signal translating unit and manipulates the body part in response to the command signal.

Abstract: A system for controlling a body part includes a number of sensing devices that sense signals from a hemisphere of a brain. A signal translating unit translates the signals into a command signal for controlling the body part, which is on a same side of the body as the hemisphere of the brain. A prosthetic device receives the command signal from the signal translating unit and manipulates the body part in response to the command signal.

Abstract: A system for controlling a body part includes a number of sensing devices that sense signals from a hemisphere of a brain. A signal translating unit translates the signals into a command signal for controlling the body part, which is on a same side of the body as the hemisphere of the brain. A prosthetic device receives the command signal from the signal translating unit and manipulates the body part in response to the command signal.

Abstract: A method for identifying a functional area of a brain. The functional area is associated with a neurological function. The method includes applying a plurality of electrodes to a surface of the brain. A slow cortical potential is determined based on one or more electrical signals produced by the plurality of electrodes. A covariance pattern is computed based on the slow cortical potential, and the configuration of co-varying electrodes is used to identify one or more areas of the brain associated with the neurological function. These co-varying patterns may be used in conjunction with other electrical and/or physiological stimulation paradigms.

Abstract: A method for identifying a functional area of a brain. The functional area is associated with a neurological function. The method includes applying a plurality of electrodes to a surface of the brain. A slow cortical potential is determined based on one or more electrical signals produced by the plurality of electrodes. A covariance pattern is computed based on the slow cortical potential, and the configuration of co-varying electrodes is used to identify one or more areas of the brain associated with the neurological function. These co-varying patterns may be used in conjunction with other electrical and/or physiological stimulation paradigms.

Abstract: Observing intracranial physiology includes inserting a bladder at least partially filled with a fluid into a subdural region of interest within a subject, wherein the bladder is coupled in flow communication with a means of indicating a pressure exerted on the bladder within the region of interest. Embodiments also include non-invasively interrogating the means of indicating to determine the pressure exerted on the bladder.

Abstract: A system for controlling a body part includes a number of sensing devices that sense signals from a hemisphere of a brain. A signal translating unit translates the signals into a command signal for controlling the body part, which is on a same side of the body as the hemisphere of the brain. A prosthetic device receives the command signal from the signal translating unit and manipulates the body part in response to the command signal.