Patents by Inventor Eric D. Brown

Eric D. Brown has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20240141649
    Abstract: A method is disclosed for producing photocatalytic coated ceramic granules. The method involves providing a coatable composition containing an inorganic binder and a variety of photocatalytic particles, such as TiO2, ZnO, Ti(OH)4, doped derivatives, or combinations thereof. These photocatalytic particles have a surface area per weight of no more than 15 m2/g. The coatable composition is then applied to uncoated base ceramic granules, resulting in intermediate coated granules. Finally, the intermediate coated granules are heated at a temperature of at least 700° C., leading to the formation of photocatalytic coated ceramic granules. These granules exhibit a Total Solar Reflectance (TSR) value of at least 0.7. This method offers an efficient and effective way to produce ceramic granules with enhanced photocatalytic properties.
    Type: Application
    Filed: January 9, 2024
    Publication date: May 2, 2024
    Inventors: Taisiya Skorina, Rebecca L. A. Everman, Jean A. Tangeman, Eric J. VanBruggen, Kenton D. Budd, Rachael A. T. Gould, Robert P. Brown, Lara K. N. Ughetta, Jonathan A. Hubin, Zachary M. Schaeffer
  • Publication number: 20240069336
    Abstract: A waveguide includes a grating structure with discontinuous regions of diffraction; regions of diffraction are interleaved with regions of no diffraction. The regions of diffraction and no diffraction may vary in size such that the width of each successive region of diffraction increases across the face of the waveguide. Neighboring regions of diffraction, separated by regions of non-diffraction, may define different periods.
    Type: Application
    Filed: August 24, 2022
    Publication date: February 29, 2024
    Inventors: Eric P. Stratton, Robert D. Brown
  • Patent number: 11160773
    Abstract: Therapeutic compositions and methods for treatment of late-onset Gaucher disease are described herein. The compositions comprise compounds having activity as pharmacological chaperones for mutant forms of the beta-glucocerebrosidase. Methods of treatment involve providing therapeutically effective amounts of such compositions to subjects in need thereof.
    Type: Grant
    Filed: April 20, 2020
    Date of Patent: November 2, 2021
    Assignees: The Hospital for Sick Children, McMaster University
    Inventors: Don J. Mahuran, Michael B. Tropak, Justin D. Buttner, Jan E. Blanchard, Eric D. Brown
  • Publication number: 20200246282
    Abstract: Therapeutic compositions and methods for treatment of late-onset Gaucher disease are described herein. The compositions comprise compounds having activity as pharmacological chaperones for mutant forms of the beta-glucocerebrosidase. Methods of treatment involve providing therapeutically effective amounts of such compositions to subjects in need thereof.
    Type: Application
    Filed: April 20, 2020
    Publication date: August 6, 2020
    Applicants: The Hospital for Sick Children, McMaster University
    Inventors: Don J. Mahuran, Michael B. Tropak, Justin D. Buttner, Jan E. Blanchard, Eric D. Brown
  • Patent number: 10653645
    Abstract: Therapeutic compositions and methods for treatment of late-onset Gaucher disease are described herein. The compositions comprise compounds having activity as pharmacological chaperones for mutant forms of the beta-glucocerebrosidase. Methods of treatment involve providing therapeutically effective amounts of such compositions to subjects in need thereof.
    Type: Grant
    Filed: June 21, 2018
    Date of Patent: May 19, 2020
    Assignees: The Hospital for Sick Children, McMaster University
    Inventors: Don J. Mahuran, Michael B. Tropak, Justin D. Buttner, Jan E. Blanchard, Eric D. Brown
  • Publication number: 20180296502
    Abstract: Therapeutic compositions and methods for treatment of late-onset Gaucher disease are described herein. The compositions comprise compounds having activity as pharmacological chaperones for mutant forms of the beta-glucocerebrosidase. Methods of treatment involve providing therapeutically effective amounts of such compositions to subjects in need thereof.
    Type: Application
    Filed: June 21, 2018
    Publication date: October 18, 2018
    Applicants: The Hospital for Sick Children, McMaster University
    Inventors: Don J. Mahuran, Michael B. Tropak, Justin D. Buttner, Jan E. Blanchard, Eric D. Brown
  • Patent number: 10028922
    Abstract: Therapeutic compositions and methods for treatment of late-onset Gaucher disease are described herein. The compositions comprise compounds having activity as pharmacological chaperones for mutant forms of the beta-glucocerebrosidase. Methods of treatment involve providing therapeutically effective amounts of such compositions to subjects in need thereof.
    Type: Grant
    Filed: July 29, 2016
    Date of Patent: July 24, 2018
    Assignees: The Hospital for Sick Children, McMaster University
    Inventors: Don J. Mahuran, Michael B. Tropak, Justin D. Buttner, Jan E. Blanchard, Eric D. Brown
  • Publication number: 20160331701
    Abstract: Therapeutic compositions and methods for treatment of late-onset Gaucher disease are described herein. The compositions comprise compounds having activity as pharmacological chaperones for mutant forms of the beta-glucocerebrosidase. Methods of treatment involve providing therapeutically effective amounts of such compositions to subjects in need thereof.
    Type: Application
    Filed: July 29, 2016
    Publication date: November 17, 2016
    Inventors: Don J. Mahuran, Michael B. Tropak, Justin D. Buttner, Jan E. Blanchard, Eric D. Brown
  • Patent number: 9415025
    Abstract: Therapeutic compositions and methods for treatment of late-onset Gaucher disease are described herein. The compositions comprise compounds having activity as pharmacological chaperones for mutant forms of the beta-glucocerebrosidase. Methods of treatment involve providing therapeutically effective amounts of such compositions to subjects in need thereof.
    Type: Grant
    Filed: December 21, 2015
    Date of Patent: August 16, 2016
    Assignees: The Hospital for Sick Children, McMaster University
    Inventors: Don J. Mahuran, Michael B. Tropak, Justin D. Buttner, Jan E. Blanchard, Eric D. Brown
  • Publication number: 20160113892
    Abstract: Therapeutic compositions and methods for treatment of late-onset Gaucher disease are described herein. The compositions comprise compounds having activity as pharmacological chaperones for mutant forms of the beta-glucocerebrosidase. Methods of treatment involve providing therapeutically effective amounts of such compositions to subjects in need thereof.
    Type: Application
    Filed: December 21, 2015
    Publication date: April 28, 2016
    Inventors: Don J. Mahuran, Michael B. Tropak, Justin D. Buttner, Jan E. Blanchard, Eric D. Brown
  • Patent number: 9233083
    Abstract: Therapeutic compositions and methods for treatment of late-onset Gaucher disease are described herein. The compositions comprise compounds having activity as pharmacological chaperones for mutant forms of the beta-glucocerebrosidase. Methods of treatment involve providing therapeutically effective amounts of such compositions to subjects in need thereof.
    Type: Grant
    Filed: April 17, 2014
    Date of Patent: January 12, 2016
    Assignees: The Hospital for Sick Children, McMaster University
    Inventors: Don J. Mahuran, Michael B. Tropak, Justin D. Buttner, Jan E. Blanchard, Eric D. Brown
  • Patent number: 9006223
    Abstract: Therapeutic compositions and methods for treatment of late-onset Gaucher disease are described herein. The compositions comprise compounds having activity as pharmacological chaperones for mutant forms of the beta-glucocerebrosidase. Methods of treatment involve providing therapeutically effective amounts of such compositions to subjects in need thereof.
    Type: Grant
    Filed: February 25, 2013
    Date of Patent: April 14, 2015
    Assignees: The Hospital for Sick Children, McMaster University
    Inventors: Don J Mahuran, Michael B Tropak, Justin D Buttner, Jan E Blanchard, Eric D Brown
  • Patent number: 8951994
    Abstract: Therapeutic compositions and methods for treatment of late-onset Gaucher disease are described herein. The compositions comprise compounds having activity as pharmacological chaperones for mutant forms of the beta-glucocerebrosidase. Methods of treatment involve providing therapeutically effective amounts of such compositions to subjects in need thereof.
    Type: Grant
    Filed: November 14, 2012
    Date of Patent: February 10, 2015
    Assignees: The Hospital for Sick Children, McMaster University
    Inventors: Don J Mahuran, Michael B Tropak, Justin D Buttner, Jan E Blanchard, Eric D Brown
  • Patent number: 8937059
    Abstract: Therapeutic compositions and methods for treatment of late-onset Gaucher disease are described herein. The compositions comprise compounds having activity as pharmacological chaperones for mutant forms of the beta-glucocerebrosidase. Methods of treatment involve providing therapeutically effective amounts of such compositions to subjects in need thereof.
    Type: Grant
    Filed: April 17, 2014
    Date of Patent: January 20, 2015
    Assignees: The Hospital for Sick Children, McMaster University
    Inventors: Don J Mahuran, Michael B Tropak, Justin D Buttner, Jan E Blanchard, Eric D Brown
  • Publication number: 20140249233
    Abstract: Therapeutic compositions and methods for treatment of late-onset Gaucher disease are described herein. The compositions comprise compounds having activity as pharmacological chaperones for mutant forms of the beta-glucocerebrosidase. Methods of treatment involve providing therapeutically effective amounts of such compositions to subjects in need thereof.
    Type: Application
    Filed: April 17, 2014
    Publication date: September 4, 2014
    Applicants: The Hospital for Sick Children, McMaster University
    Inventors: Don J. Mahuran, Michael B. Tropak, Justin D. Buttner, Jan E. Blanchard, Eric D. Brown
  • Publication number: 20140235713
    Abstract: Therapeutic compositions and methods for treatment of late-onset Gaucher disease are described herein. The compositions comprise compounds having activity as pharmacological chaperones for mutant forms of the beta-glucocerebrosidase. Methods of treatment involve providing therapeutically effective amounts of such compositions to subjects in need thereof.
    Type: Application
    Filed: April 17, 2014
    Publication date: August 21, 2014
    Applicants: The Hospital for Sick Children, McMaster University
    Inventors: Don J. Mahuran, Michael B. Tropak, Justin D. Buttner, Jan E. Blanchard, Eric D. Brown
  • Publication number: 20140088069
    Abstract: An antibacterial composition is provided including a combination of a ?-lactam antibiotic that has a binding affinity for bacterial penicillin-binding protein 2; and a non-antibiotic compound which may be a thienopyridine or a non-thienopyridine compound. A method of treatment using the composition is also provided.
    Type: Application
    Filed: November 29, 2013
    Publication date: March 27, 2014
    Inventors: Eric D. Brown, Maya Farha, Alexander Leung, Gerry Wright, Kalinka Koteva, Ted Sewell, Linda Ejim
  • Patent number: 8404668
    Abstract: Therapeutic compositions and methods for treatment of late-onset Gaucher disease are described herein. The compositions comprise compounds having activity as pharmacological chaperones for mutant forms of the beta-glucocerebrosidase. Methods of treatment involve providing therapeutically effective amounts of such compositions to subjects in need thereof.
    Type: Grant
    Filed: September 29, 2011
    Date of Patent: March 26, 2013
    Assignees: The Hospital for Sick Children, McMaster University
    Inventors: Don J. Mahuran, Michael B. Tropak, Justin D. Buttner, Jan E. Blanchard, Eric D. Brown
  • Patent number: 8124597
    Abstract: Therapeutic compositions and methods for treatment of late-onset Gaucher disease are described herein. The compositions comprise compounds having activity as pharmacological chaperones for mutant forms of the beta-glucocerebrosidase. Methods of treatment involve providing therapeutically effective amounts of such compositions to subjects in need thereof.
    Type: Grant
    Filed: August 22, 2008
    Date of Patent: February 28, 2012
    Assignees: The Hospital for Sick Children, McMaster University
    Inventors: Don J. Mahuran, Michael B. Tropak, Justin D. Buttner, Jan E. Blanchard, Eric D. Brown
  • Publication number: 20120021487
    Abstract: Therapeutic compositions and methods for treatment of late-onset Gaucher disease are described herein. The compositions comprise compounds having activity as pharmacological chaperones for mutant forms of the beta-glucocerebrosidase. Methods of treatment involve providing therapeutically effective amounts of such compositions to subjects in need thereof.
    Type: Application
    Filed: September 29, 2011
    Publication date: January 26, 2012
    Applicants: McMASTER UNIVERSITY, THE HOSPITAL FOR SICK CHILDREN
    Inventors: Don J Mahuran, Michael B. Tropak, Justin D. Buttner, Jan E. Blanchard, Eric D. Brown