Abstract: Disclosed herein are systems, methods, and a targeted temperature management (TTM) pad to facilitate thermal energy transfer between TTM fluid and a patient. The TTM pad includes a pad portion for placement on the patient and a fluid delivery conduit. The fluid delivery conduit can include a delivery conduit connector at a proximal end thereof and a fluid return conduit extending away from the pad portion. The fluid return conduit can include a return conduit connector at a proximal end thereof, and a connector coupled to a distal end of each of the fluid delivery conduit and the fluid return conduit. The connector can include a membrane configured to cover openings of both of the fluid delivery conduit and the fluid return conduit or includes multiple membranes, wherein the one or more membranes can include a piercing corresponding to each of the fluid delivery conduit and the fluid return conduit.