Patents by Inventor Eric D. Wieben

Eric D. Wieben has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Phenylethanolamine-N-methyltransferase sequence variants
    Patent number: 7371523
    Abstract: Isolated PNMT nucleic acid molecules that include a nucleotide sequence variant and nucleotides flanking the sequence variant are described, as well as PNMT allozymes. Methods for determining if a subject is predisposed to multiple sclerosis, early-onset Alzheimer's disease, or Parkinson's disease also are described.
    Type: Grant
    Filed: January 9, 2004
    Date of Patent: May 13, 2008
    Assignee: Mayo Foundation for Medical Education and Research
    Inventors: Bianca A. Thomae, Eric D. Wieben, Richard M. Weinshilboum, Yuan Ji
  • Sulfotransferase 2B1 pharmacogenetics
    Patent number: 7288642
    Abstract: Isolated sulfotransferase nucleic acid molecules that include a nucleotide sequence variant and nucleotides flanking the sequence variant are described, as are sulfotransferase allozymes. Methods for determining the sulfonator status of a subject also are described. In addition, methods for predicting the therapeutic efficacy of a compound in a subject are described, as are methods for estimating the dose of a compound to be administered to a subject.
    Type: Grant
    Filed: November 6, 2003
    Date of Patent: October 30, 2007
    Assignee: Mayo Foundation for Medical Education and Research
    Inventors: Bianca A. Thomae, Eric D. Wieben, Richard M. Weinshilboum
  • 3?-phosphoadenosine-5?-phosphosulfate synthetase 1 (PAPSS1) sequence variants
    Patent number: 7288399
    Abstract: Isolated PAPSS1 nucleic acid molecules that include a nucleotide sequence variant and nucleotides flanking the sequence variant are described, as well as PAPSS1 allozymes. Methods for determining if a mammal is predisposed to joint disease or cancer also are described.
    Type: Grant
    Filed: May 2, 2006
    Date of Patent: October 30, 2007
    Assignee: Mayo Foundation for Medical Education and Research
    Inventors: Zhenhua Xu, Eric D. Wieben, Richard M. Weinshilboum
  • Sulfotransferase 1E1 sequence variants
    Patent number: 7288641
    Abstract: Isolated sulfotransferase nucleic acid molecules that include a nucleotide sequence variant and nucleotides flanking the sequence variant are described, as well as sulfotransferase allozymes. Methods for determining if a mammal is predisposed to cancer also are described.
    Type: Grant
    Filed: January 30, 2003
    Date of Patent: October 30, 2007
    Assignee: Mayo Foundation for Medical Education and Research
    Inventors: Araba A. Adjei, Eric D. Wieben, Richard M. Weinshilboum, Bianca A. Thomae
  • Arsenic methyltransferase sequence variants
    Patent number: 7250290
    Abstract: Isolated ASMT nucleic acid molecules that include a nucleotide sequence variant and nucleotides flanking the sequence variant are described, as well as ASMT allozymes. Methods for determining if a mammal is at risk for toxicity from acute or chronic arsenic exposure also are described.
    Type: Grant
    Filed: April 15, 2004
    Date of Patent: July 31, 2007
    Assignee: Mayo Foundation for Medical Education and Research
    Inventors: Bianca A. Thomae, Eric D. Wieben, Richard M. Weinshilboum, Thomas C. Wood
  • 3?-phosphoadenosine -5?-phosphosulfate synthetase 2 (PAPSS2) sequence variants
    Patent number: 7186551
    Abstract: Isolated PAPSS2 nucleic acid molecules that include a nucleotide sequence variant and nucleotides flanking the sequence variant are described, as well as PAPSS2 allozymes. Methods for determining if a mammal is predisposed to joint disease or cancer also are described.
    Type: Grant
    Filed: November 14, 2002
    Date of Patent: March 6, 2007
    Assignee: Mayo Foundation for Medical Education and Research
    Inventors: Zhenhua Xu, Eric D. Wieben, Richard M. Weinshilboum
  • 3?-phosphoadenosine-5?-phosphosulfate synthetase 1 (PAPSS1) sequence variants
    Patent number: 7067311
    Abstract: Isolated PAPSS1 nucleic acid molecules that include a nucleotide sequence variant and nucleotides flanking the sequence variant are described, as well as PAPSS1 allozymes. Methods for determining if a mammal is predisposed to joint disease or cancer also are described.
    Type: Grant
    Filed: November 14, 2002
    Date of Patent: June 27, 2006
    Assignee: Mayo Foundation for Medical Education and Research
    Inventors: Zhenhua Xu, Eric D. Wieben, Richard M. Weinshilboum
  • Sulfotransferase SULT2A1 sequence variants
    Patent number: 7056731
    Abstract: Isolated sulfotransferase nucleic acid molecules that include a nucleotide sequence variant and nucleotides flanking the sequence variant are described, as well as sulfotransferase allozymes. Methods for determining if a mammal is predisposed to a heart condition or cancer also are described.
    Type: Grant
    Filed: June 21, 2002
    Date of Patent: June 6, 2006
    Assignee: Mayo Foundation for Medical Education and Research
    Inventors: Bianca A. Thomae, Eric D. Wieben, Richard M. Weinshilboum
  • Sulfotransferase sequence variants
    Patent number: 7026163
    Abstract: Isolated sulfotransferase nucleic acid molecules that include a nucleotide sequence variant and nucleotides flanking the sequence variant are described, as well as sulfotransferase allozymes. Methods for determining if a mammal is predisposed to thyroid disease or cancer also are described.
    Type: Grant
    Filed: February 23, 2001
    Date of Patent: April 11, 2006
    Assignee: Mayo Foundation for Medical Education and Research
    Inventors: Robert R. Freimuth, Eric D. Wieben, Richard M. Weinshilboum
  • Stably-transformed cells expressing human thiopurine methyltransferase
    Patent number: 5470737
    Abstract: A recombinant DNA sequence is provided which encodes human thiopurine methyl transferase (TPMT), as well as a mammalian cell line having said recombinant DNA sequence incorporated into the genome thereof, so that the cells express high levels of human TPMT activity.
    Type: Grant
    Filed: October 3, 1994
    Date of Patent: November 28, 1995
    Assignee: Mayo Foundation for Medical Education and Research
    Inventors: Richard M. Weinshilboum, Ronald Honchel, Ibrahim A. Aksoy, Carol L. Szumlanski, Thomas C. Wood, Diane M. Otterness, Eric D. Wieben