Patents by Inventor Eric Dadey
Eric Dadey has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 8877225Abstract: The present invention provides a constant release copolymer composition adapted for use in a controlled release formulation for a bioactive agent, such as a formulation adapted for implantation within a patient's body tissues as a depot to release the agent over a period of time, wherein the copolymer provides a substantially constant rate of release of the bioactive agent over the time period for which the depot persists in the body tissues. The copolymer includes a PLG copolymer and a PLG oligomer of about 5-10 kDa average molecular weight, which can lack free carboxylic acid groups. When the PLG copolymer is a low burst copolymer, the constant release copolymer composition is a low burst, constant release copolymer composition adapted for implantation in the body tissues of a mammal, wherein a substantially constant rate of release of the bioactive agent is achieved.Type: GrantFiled: June 3, 2009Date of Patent: November 4, 2014Assignee: Tolmar Therapeutics, Inc.Inventors: Richard L. Norton, Eric Dadey
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Publication number: 20140261990Abstract: The present invention relates to a method of forming a multi-layered film product, including the steps of forming a single-layered film having a length and a width and folding said single-layered film over on itself along said length at least once to form a multi-layered film having at least 2 layers in a face-to-face engagement. The single-layered film includes at least 2 lanes in a side-by-side arrangement along the length of the single layered film, wherein: a) each of said lanes spans the length of said single-layered film; b) each of said lanes spans at least a portion of the width of said single-layered film; c) said lanes that are adjacent to one another meet at a fold line that runs parallel to the length of said single-layered film; and d) at least one of said at least 2 lanes comprises at least one active component.Type: ApplicationFiled: March 15, 2013Publication date: September 18, 2014Applicant: MONOSOL RX, LLCInventors: Eric Dadey, Daniel R. Barber
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Publication number: 20140275194Abstract: The invention relates to film products including a polymer component and a therapeutically effective amount of rizatriptan or a pharmaceutically acceptable salt thereof. The invention further relates to film products including a polymer component and a therapeutically effective amount of rizatriptan benzoate.Type: ApplicationFiled: March 15, 2013Publication date: September 18, 2014Inventors: Eric Dadey, Alexander Mark Schobel, Daniel R. Barber, Garry L. Myers
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Publication number: 20140271789Abstract: The present invention relates to products and methods for treatment of various symptoms in a patient, including treatment of pain suffered by a patient. The invention more particularly relates to self-supporting dosage forms which provide an active agent while providing sufficient buccal adhesion of the dosage form. Further, the present invention provides a dosage form which is useful in reducing the likelihood of diversion abuse of the active agent.Type: ApplicationFiled: March 4, 2014Publication date: September 18, 2014Applicant: MonoSol Rx, LLCInventors: Garry L. Myers, Eric Dadey
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Publication number: 20140255473Abstract: The present invention is directed to steroid hormone delivery systems and methods of preparing the same. In particular, the steroid hormone delivery systems provided include a primary construct having one or more hydrophobic steroid hormone esters in the form of a liposome, a lipid particle, a micelle, an emulsion or a niosome which is then formulated into a secondary construct for administration. Exemplary secondary constructs include a film for sublingual or buccal administration.Type: ApplicationFiled: May 19, 2014Publication date: September 11, 2014Applicant: MONOSOL RX, LLCInventors: Eric Dadey, Alexander Mark Schobel
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Patent number: 8790704Abstract: Nanoparticles having a core and a corona of ligands covalently linked to the core, wherein differing species of peptides are bound to the nanoparticles and incorporated into various dosage forms.Type: GrantFiled: June 8, 2012Date of Patent: July 29, 2014Assignees: Monosol RX, LLC, Midatech LimitedInventors: Phillip Williams, Thomas Rademacher, Alexander Mark Schobel, Eric Dadey
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Publication number: 20140094484Abstract: The present invention relates to a rapamycin sustained release delivery system for treatment of diseases responsive to rapamycin. The sustained release delivery system of the invention includes a flowable composition containing rapamycin or a rapamycin derivative, which is capable of providing an implant containing the rapamycin or derivative thereof. The flowable composition may be injected into tissue whereupon it coagulates to become the solid or gel, monolithic implant. The flowable composition includes a biodegradable, thermoplastic polymer, an organic liquid and rapamycin or a rapamycin derivative.Type: ApplicationFiled: October 2, 2012Publication date: April 3, 2014Applicants: QLT Inc., Tolmar Therapeutics, Inc.Inventors: Philippe Maria Clotaire Margaron, Eric Dadey, Christopher M. Lindemann, Ruihong Li
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Publication number: 20140073678Abstract: In one aspect, the present invention discloses combinational compositions for treating users experiencing symptoms associated with a migraine or other central nervous system related pain disorder that can cause or exacerbate nausea and/or vomiting or other central nervous system related pain disorder that can cause or exacerbate nausea and/or vomiting. The combinational composition includes a first pharmaceutical active component for treating pain, and a second pharmaceutical active component for treating nausea and/or vomiting and/or vomiting in a user.Type: ApplicationFiled: March 15, 2013Publication date: March 13, 2014Applicant: MONOSOL RX, LLCInventors: Eric Dadey, Alexander Mark Schobel, Daniel R. Barber, Garry L. Myers
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Publication number: 20130045271Abstract: The present invention is directed to steroid hormone delivery systems and methods of preparing the same. In particular, the steroid hormone delivery systems provided include a primary construct having one or more hydrophobic steroid hormone esters in the form of a liposome, a lipid particle, a micelle, an emulsion or a niosome which is then formulated into a secondary construct for administration. Exemplary secondary constructs include a film for sublingual or buccal administration.Type: ApplicationFiled: August 17, 2012Publication date: February 21, 2013Applicant: MonoSol Rx, LLCInventors: Eric Dadey, Alexander Mark Schobel
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Publication number: 20120301535Abstract: Nanoparticles having a core and a corona of ligands covalently linked to the core, wherein differing species of peptides are bound to the nanoparticles and incorporated into various dosage forms.Type: ApplicationFiled: June 8, 2012Publication date: November 29, 2012Inventors: Phillip Williams, Thomas Rademacher, Alexander Mark Schobel, Eric Dadey
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Patent number: 8313763Abstract: The present invention relates to a rapamycin sustained release delivery system for treatment of diseases responsive to rapamycin. The sustained release delivery system of the invention includes a flowable composition containing rapamycin or a rapamycin derivative, which is capable of providing an implant containing the rapamycin or derivative thereof. The flowable composition may be injected into tissue whereupon it coagulates to become the solid or gel, monolithic implant. The flowable composition includes a biodegradable, thermoplastic polymer, an organic liquid and rapamycin or a rapamycin derivative.Type: GrantFiled: February 15, 2007Date of Patent: November 20, 2012Assignee: Tolmar Therapeutics, Inc.Inventors: Philippe Maria Clotaire Margaron, Eric Dadey, Christopher M. Lindemann, Ruihong Li
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Patent number: 8173148Abstract: The invention relates to a delivery system for the sustained and controlled delivery of a group of bioactive agents. More particularly, the invention relates to a delivery system and a method for delivery of a bioactive agent containing a nucleophilic functional group by means of a biodegradable, sustained-release implant. The implant may be a preformed implant, microparticles or an in situ formed implant. The implant includes a biodegradable thermoplastic polymer, the bioactive agent having a nucleophilic group substituent and a stabilizing associate as well as other optional components. The combination of the stabilizing associate with the bioactive agent prevents and/or minimizes and/or lessens degradation of the thermoplastic polymer by the bioactive agent.Type: GrantFiled: November 10, 2005Date of Patent: May 8, 2012Assignee: Tolmar Therapeutics, Inc.Inventors: Eric Dadey, Mingxing Zhou
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Publication number: 20110171305Abstract: The invention provides a controlled release biodegradable polymer formulation adapted for administering bioactive agents such as therapeutic proteins to a patient through implantation of a bolus that forms a depot within the patient's body tissues. The formulation includes a dehydrated inclusion complex of the bioactive agent within a hydrogel, wherein the hydrogel can comprise a polymerized polyalkyleneglycolyl diacrylate, and, optionally, polyalkyleneglycolyl monoacrylates, including methacrylates. Alternatively, the hydrogel can comprise hyaluronic acid, chitosan, agarose, polyvinylacetate, polyvinylpyrrolide, or polyvinylalcohol nanoparticles. The bioactive agent can be a macromolecular material, such as a protein. A method of forming the inventive formulation is also provided, as well as a method for using the formulation in the treatment of a malcondition in a patient in need thereof.Type: ApplicationFiled: June 3, 2009Publication date: July 14, 2011Applicant: QLT USA Inc.Inventors: Eric Dadey, Andrew (Drew) Watkins
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Publication number: 20100292195Abstract: A PLG copolymer material, termed a PLG(p) copolymer material, adapted for use in a controlled release formulation for a bioactive material is provided, wherein the formulation exhibits a reduced “initial burst” effect when introduced into the tissue of a patient in need thereof. A method of preparation of the PLG copolymer material is also provided, as are methods of use.Type: ApplicationFiled: February 13, 2008Publication date: November 18, 2010Applicant: QLT USA, INC.Inventors: Eric Dadey, John Middleton, Richard L. Norton
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Publication number: 20100266655Abstract: The present invention relates to a risperidone sustained release delivery system for treatment of medical conditions relating delusional psychosis, schizophrenia, bipolar disorder, psychotic depression, obsessive-compulsion disorder, Tourette syndrome, and autistic spectrum disorders. The sustained release delivery system includes a flowable composition containing risperidone, a metabolite, or a prodrug thereof and an implant containing risperidone, a metabolite, or a prodrug thereof. The flowable composition may be injected into tissue whereupon it coagulates to become the solid or gel, monolithic implant. The flowable composition includes a biodegradable, thermoplastic polymer, an organic liquid, and risperidone, a metabolite, or a prodrug thereof.Type: ApplicationFiled: February 13, 2008Publication date: October 21, 2010Applicant: QLT USA INCInventor: Eric Dadey
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Publication number: 20090325879Abstract: The present invention provides a constant release copolymer composition adapted for use in a controlled release formulation for a bioactive agent, such as a formulation adapted for implantation within a patient's body tissues as a depot to release the agent over a period of time, wherein the copolymer provides a substantially constant rate of release of the bioactive agent over the time period for which the depot persists in the body tissues. The copolymer includes a PLG copolymer and a PLG oligomer of about 5-10 kDa average molecular weight, which can lack free carboxylic acid groups. When the PLG copolymer is a low burst copolymer, the constant release copolymer composition is a low burst, constant release copolymer composition adapted for implantation in the body tissues of a mammal, wherein a substantially constant rate of release of the bioactive agent is achieved.Type: ApplicationFiled: June 3, 2009Publication date: December 31, 2009Applicant: QLT USA, INC.Inventors: Richard L. Norton, Eric Dadey
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Publication number: 20090092650Abstract: The present invention relates to an octreotide sustained release delivery system for treatment of diseases relating to somatotropin and/or somatostatin. The sustained release delivery system of the invention includes a flowable composition containing an octreotide compound, and an implant containing the octreotide compound. The flowable composition may be injected into tissue whereupon it coagulates to become the solid or gel, monolithic implant. The flowable composition includes a biodegradable, thermoplastic polymer, an organic liquid and an octreotide compound.Type: ApplicationFiled: December 15, 2005Publication date: April 9, 2009Inventors: Stephen L. Warren, Eric Dadey, Richard L. Dunn, John Milton Downing, Ellen Qi Li
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Publication number: 20080299168Abstract: The invention relates to a delivery system for the sustained and controlled delivery of a group of bioactive agents. More particularly, the invention relates to a delivery system and a method for delivery of a bioactive agent containing a nucleophilic functional group by means of a biodegradable, sustained-release implant. The implant may be a preformed implant, microparticles or an in situ formed implant. The implant includes a biodegradable thermoplastic polymer, the bioactive agent having a nucleophilic group substituent and a stabilizing associate as well as other optional components. The combination of the stabilizing associate with the bioactive agent prevents and/or minimizes and/or lessens degradation of the thermoplastic polymer by the bioactive agent.Type: ApplicationFiled: November 10, 2005Publication date: December 4, 2008Inventors: Eric Dadey, Mingxing Zhou
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Publication number: 20070280992Abstract: The present invention relates to a rapamycin sustained release delivery system for treatment of diseases responsive to rapamycin. The sustained release delivery system of the invention includes a flowable composition containing rapamycin or a rapamycin derivative, which is capable of providing an implant containing the rapamycin or derivative thereof. The flowable composition may be injected into tissue whereupon it coagulates to become the solid or gel, monolithic implant. The flowable composition includes a biodegradable, thermoplastic polymer, an organic liquid and rapamycin or a rapamycin derivative.Type: ApplicationFiled: February 15, 2007Publication date: December 6, 2007Applicant: QLT USA, INC.Inventors: Philippe Margaron, Eric Dadey, Christopher Lindemann, Ruihong Li
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Publication number: 20060210604Abstract: The present invention provides a flowable composition suitable for use as a controlled release implant. The flowable composition can be administered into the ocular region of a mammal. The composition includes: (a) a biodegradable, biocompatible thermoplastic polymer that is at least substantially insoluble in aqueous medium, water or body fluid; (b) a biological agent, a metabolite thereof, a biological agently acceptable salt thereof, or a prodrug thereof; and (c) a biocompatible organic liquid, at standard temperature and pressure, in which the thermoplastic polymer is soluble. The present invention also provides methods of medical treatment that include administering the flowable composition into the ocular region of a mammal.Type: ApplicationFiled: October 4, 2005Publication date: September 21, 2006Inventors: Eric Dadey, Christopher Lindemann, Stephen Warren, Richard Norton